Κυτταρογενετική μελέτη των κακοηθών λεμφωμάτων της παιδικής ηλικίας

The karyotype of the neoplastic cells of the lymph nodes of 16 patients with malignant lymphoma, 3-16 of age, is examined in this study. Histologically the lymphomas were classified as follows: 6 lymphoblastic type, 4 diffuse «histiocytic» type, 3 undifferentiated type, 1 follicular small cleaved cell type and two cases of Hodgkin's disease. 13 patients showed chromosomal abnormalities and three patients had normal karyotype. In these 13 patients, 16 structural atypias were identified. From these, 9 were chromosomal translocations, from which three were translocation t(14;18) (q32;q21), one t(8;14) (q24;q32), one t(9;14) (p13;q32), one t(2;12) (q12;pll), one t(7;19) (q11;q13), one t(3;5)(p24;q35) and one t(16;?) (p13;?). Also there were identified the deletions del (2q) and del (14) (q22), the duplication dup (1q) (two cases) and the atypias 14q+ (two cases) and 16q+. From the above findings it is obvious that the lymphomas of childhood show frequently chromosomal abnormalities, some of which have common break points in chromosomes. None of the structural abnormalities was found to be associated with a certain histological type except dup (1q) which was observed in two cases with diffuse histiocytic lymphoma. For the significance of these abnormalities in the pathogenesis, the course and the prognosis of the disease several hypotheses have been stated in the literature. Nevertheless, the limited number of studies, at present, does not allow to encode these findings and associate them with the above parameters. A contribution towards this direction is made by our observations.

Grantor dc:publisher

Aristotle University Of Thessaloniki (AUTH)

Year dc:date

1990

Authors dc:creator

• Miliaras, Dimosthenis
• Μηλιαράς, Δημοσθένης

• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1367

OAI identifier oai:identifier

oai:10442/1367