{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1249"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1249","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ. ΤΥΠΟΠΟΙΗΣΗ ΚΑΙ ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΤΩΝ ΤΥΠΩΝ 1 ΚΑΙ 2 ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ (HSV)","abstract":"STUDY ON THE ANTIGEN PRODUCTION OF HSV-1/733 AND HSV-2/734 FROM INFECTED CELL CULTURES, THE PRODUCTION OF MONOSPECIFIC ANTISERA, THE DETECTION AND ISOLATION OF SPECIFIC ANTIGENS FOR THE TWO TYPES OF VIRUS. TYPING OF 40 ISOLATES FROM DIFFERENT HERPETIC LESIONS OF PATIENTS. THE TYPING OF THESE ISOLATES WAS ACHIEVED BY ELISA USING THE PRODUCED MONOSPECIFIC SERA. THE RESULTS WERE CONFIRMED BY RESTRICTION ENZYME DNA ANALYSIS IN 29 CASES PROVING THAT THE MONOSPECIFIC ANTISERARAISED AGAINST THE TYPE SPECIFIC ANTIGENS OF EACH TYPE (HSV-1 OR HSV-2) CAN BEUSED IN ELISA FOR THE TYPING OF HSV ISOLATES. PRESENTATION OF RESULTS OF ANTIBODY DETECTION IN HUMAN SERA AGAINST THE TWO TYPES OF HSV. THESE RESULTS SHOWED THE PREPARED SPECIFIC ANTIGENS ARE MUCH MORE TYPE- SPECIFIC THAN AVAILABLE COMMERCIALIZED ANTIGENS AND CAN BE USED FOR THE DETECTION OF TYPE SPECIFIC ANTIBODIES BY ELISA.","abstract_html":"STUDY ON THE ANTIGEN PRODUCTION OF HSV-1/733 AND HSV-2/734 FROM INFECTED CELL CULTURES, THE PRODUCTION OF MONOSPECIFIC ANTISERA, THE DETECTION AND ISOLATION OF SPECIFIC ANTIGENS FOR THE TWO TYPES OF VIRUS. TYPING OF 40 ISOLATES FROM DIFFERENT HERPETIC LESIONS OF PATIENTS. THE TYPING OF THESE ISOLATES WAS ACHIEVED BY ELISA USING THE PRODUCED MONOSPECIFIC SERA. THE RESULTS WERE CONFIRMED BY RESTRICTION ENZYME DNA ANALYSIS IN 29 CASES PROVING THAT THE MONOSPECIFIC ANTISERARAISED AGAINST THE TYPE SPECIFIC ANTIGENS OF EACH TYPE (HSV-1 OR HSV-2) CAN BEUSED IN ELISA FOR THE TYPING OF HSV ISOLATES. PRESENTATION OF RESULTS OF ANTIBODY DETECTION IN HUMAN SERA AGAINST THE TWO TYPES OF HSV. THESE RESULTS SHOWED THE PREPARED SPECIFIC ANTIGENS ARE MUCH MORE TYPE- SPECIFIC THAN AVAILABLE COMMERCIALIZED ANTIGENS AND CAN BE USED FOR THE DETECTION OF TYPE SPECIFIC ANTIBODIES BY ELISA.","abstract_has_math":false,"creators":["Markoulatos, Panagiotis","Μαρκουλάτος, Παναγιώτης"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989","date_published":"1989","updated_at":"2026-07-24T02:24:49Z","subjects":["ELISA","Herpes simplex virus 1","TYPING OF ISOLATED STRAINS HSV-1, HSV-2","Western blot","ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ","ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ ΤΩΝ 2 ΤΥΠΩΝ ΤΟΥ ΙΟΥ (HSV)","ΙΟΣ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ ΤΥΠΟΥ 1 ΚΑΙ 2","ΤΥΠΟΠΟΙΗΣΗ ΣΤΕΛΕΧΩΝ HSV-1 ΚΑΙ HSV-2","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1249"],"render_values":[{"text":"10.12681/eadd/1249","href":"https://doi.org/10.12681/eadd/1249","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1249","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Markoulatos, Panagiotis","Μαρκουλάτος, Παναγιώτης"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ELISA","Herpes simplex virus 1","TYPING OF ISOLATED STRAINS HSV-1, HSV-2","Western blot","ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ","ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ ΤΩΝ 2 ΤΥΠΩΝ ΤΟΥ ΙΟΥ (HSV)","ΙΟΣ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ ΤΥΠΟΥ 1 ΚΑΙ 2","ΤΥΠΟΠΟΙΗΣΗ ΣΤΕΛΕΧΩΝ HSV-1 ΚΑΙ HSV-2","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1249","http://hdl.handle.net/10442/hedi/1249"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["STUDY ON THE ANTIGEN PRODUCTION OF HSV-1/733 AND HSV-2/734 FROM INFECTED CELL CULTURES, THE PRODUCTION OF MONOSPECIFIC ANTISERA, THE DETECTION AND ISOLATION OF SPECIFIC ANTIGENS FOR THE TWO TYPES OF VIRUS. TYPING OF 40 ISOLATES FROM DIFFERENT HERPETIC LESIONS OF PATIENTS. THE TYPING OF THESE ISOLATES WAS ACHIEVED BY ELISA USING THE PRODUCED MONOSPECIFIC SERA. THE RESULTS WERE CONFIRMED BY RESTRICTION ENZYME DNA ANALYSIS IN 29 CASES PROVING THAT THE MONOSPECIFIC ANTISERARAISED AGAINST THE TYPE SPECIFIC ANTIGENS OF EACH TYPE (HSV-1 OR HSV-2) CAN BEUSED IN ELISA FOR THE TYPING OF HSV ISOLATES. PRESENTATION OF RESULTS OF ANTIBODY DETECTION IN HUMAN SERA AGAINST THE TWO TYPES OF HSV. THESE RESULTS SHOWED THE PREPARED SPECIFIC ANTIGENS ARE MUCH MORE TYPE- SPECIFIC THAN AVAILABLE COMMERCIALIZED ANTIGENS AND CAN BE USED FOR THE DETECTION OF TYPE SPECIFIC ANTIBODIES BY ELISA.","ΜΕΛΕΤΗ ΤΗΣ ΑΝΑΠΤΥΞΗΣ ΤΩΝ ΠΡΟΤΥΠΩΝ ΣΤΕΛΕΧΩΝ HSV-1/733 ΚΑΙ HSV- 2/734 ΣΕ ΚΥΤΤΑΡΟΚΑΛΛΙΕΡΓΗΤΟ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΑΝΤΙΓΟΝΩΝ, ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΠΟΛΥΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ ΤΗΣ ΑΝΑΖΗΤΗΣΗΣ, ΕΝΤΟΠΙΣΗΣ ΚΑΙ ΑΠΟΜΟΝΩΣΗΣ ΕΙΔΙΚΩΝ ΓΙΑ ΚΑΘΕ ΤΥΠΟ ΑΝΤΙΓΟΝΙΚΩΝ ΚΑΘΟΡΙΣΤΩΝ ΚΑΘΩΣ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΚΑΙ ΤΟΥ ΕΛΕΓΧΟΥ ΤΩΝ ΜΟΝΟΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ. Η ΑΠΟΜΟΝΩΣΗ ΕΙΔΙΚΩΝ ΑΝΤΙΓΟΝΙΚΩΝ ΚΑΘΟΡΙΣΤΩΝ ΓΙΑ ΤΟΝ ΤΥΠΟ HSV-1 ΚΑΙ ΓΙΑ ΤΟΝ ΤΥΠΟ HSV-2 ΕΠΙΤΡΕΠΕΙ ΤΗΝ ΠΑΡΑΓΩΓΗ ΜΟΝΟΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ ΟΙ ΟΠΟΙΟΙ ΧΡΗΣΙΜΟΠΟΙΟΥΝΤΑΙ ΓΙΑ ΤΗΝ ΤΥΠΟΠΟΙΗΣΗ 40 ΣΤΕΛΕΧΩΝ ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ ΜΕ ΤΗΝ ΜΕΘΟΔΟ ELISA. Η ΠΡΟΕΛΕΥΣΗ ΤΩΝ ΣΤΕΛΕΧΩΝ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΗΣ ΤΥΠΟΠΟΙΗΣΗΣ ΚΑΘΩΣ ΚΑΙ Η ΕΠΙΒΕΒΑΙΩΣΗ ΜΕ ΤΗΝ ΧΡΗΣΗ ΠΕΡΙΟΡΙΣΤΙΚΩΝ ΕΝΖΥΜΩΝ ΑΠΟΔΕΙΚΝΥΟΥΝ ΟΤΙ Η ΧΡΗΣΙΜΟΠΟΙΗΣΗ ΤΩΝ ΠΑΡΑΧΘΕΝΤΩΝ ΜΟΝΟΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ ΠΡΟΣΦΕΡΕΤΑΙ ΓΙΑ ΤΗΝ ΑΚΡΙΒΗ ΤΥΠΟΠΟΙΗΣΗ ΤΩΝ ΣΤΕΛΕΧΩΝ ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ. ΠΑΡΟΥΣΙΑΣΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΤΟΥ ΠΡΟΣΔΙΟΡΙΣΜΟΥ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΤΩΝ 2 ΤΥΠΩΝ ΤΟΥ ΙΟΥ ΚΑΘΩΣ ΚΑΙ ΣΥΓΚΡΙΤΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ."]},{"key":"dc:title","label":"Title","values":["ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ. ΤΥΠΟΠΟΙΗΣΗ ΚΑΙ ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΤΩΝ ΤΥΠΩΝ 1 ΚΑΙ 2 ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ (HSV)","ANTIGENIC STUDY OF HERPES SIMPLEX VIRUS TYPE 1 (HSV-1) AND TYPE 2 (HSV-2), TYPING OF ISOLATED STRAINS AND DETECTION OF TYPE SPECIFIC ANTIBODIES TO HSV-1 AND HSV-2"]}]}],"canonical_facts":{"dc:creator":["Markoulatos, Panagiotis","Μαρκουλάτος, Παναγιώτης"],"dc:date":["1989"],"dc:description":["STUDY ON THE ANTIGEN PRODUCTION OF HSV-1/733 AND HSV-2/734 FROM INFECTED CELL CULTURES, THE PRODUCTION OF MONOSPECIFIC ANTISERA, THE DETECTION AND ISOLATION OF SPECIFIC ANTIGENS FOR THE TWO TYPES OF VIRUS. TYPING OF 40 ISOLATES FROM DIFFERENT HERPETIC LESIONS OF PATIENTS. THE TYPING OF THESE ISOLATES WAS ACHIEVED BY ELISA USING THE PRODUCED MONOSPECIFIC SERA. THE RESULTS WERE CONFIRMED BY RESTRICTION ENZYME DNA ANALYSIS IN 29 CASES PROVING THAT THE MONOSPECIFIC ANTISERARAISED AGAINST THE TYPE SPECIFIC ANTIGENS OF EACH TYPE (HSV-1 OR HSV-2) CAN BEUSED IN ELISA FOR THE TYPING OF HSV ISOLATES. PRESENTATION OF RESULTS OF ANTIBODY DETECTION IN HUMAN SERA AGAINST THE TWO TYPES OF HSV. THESE RESULTS SHOWED THE PREPARED SPECIFIC ANTIGENS ARE MUCH MORE TYPE- SPECIFIC THAN AVAILABLE COMMERCIALIZED ANTIGENS AND CAN BE USED FOR THE DETECTION OF TYPE SPECIFIC ANTIBODIES BY ELISA.","ΜΕΛΕΤΗ ΤΗΣ ΑΝΑΠΤΥΞΗΣ ΤΩΝ ΠΡΟΤΥΠΩΝ ΣΤΕΛΕΧΩΝ HSV-1/733 ΚΑΙ HSV- 2/734 ΣΕ ΚΥΤΤΑΡΟΚΑΛΛΙΕΡΓΗΤΟ ΓΙΑ ΤΗΝ ΠΑΡΑΣΚΕΥΗ ΑΝΤΙΓΟΝΩΝ, ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΠΟΛΥΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ ΤΗΣ ΑΝΑΖΗΤΗΣΗΣ, ΕΝΤΟΠΙΣΗΣ ΚΑΙ ΑΠΟΜΟΝΩΣΗΣ ΕΙΔΙΚΩΝ ΓΙΑ ΚΑΘΕ ΤΥΠΟ ΑΝΤΙΓΟΝΙΚΩΝ ΚΑΘΟΡΙΣΤΩΝ ΚΑΘΩΣ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΚΑΙ ΤΟΥ ΕΛΕΓΧΟΥ ΤΩΝ ΜΟΝΟΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ. Η ΑΠΟΜΟΝΩΣΗ ΕΙΔΙΚΩΝ ΑΝΤΙΓΟΝΙΚΩΝ ΚΑΘΟΡΙΣΤΩΝ ΓΙΑ ΤΟΝ ΤΥΠΟ HSV-1 ΚΑΙ ΓΙΑ ΤΟΝ ΤΥΠΟ HSV-2 ΕΠΙΤΡΕΠΕΙ ΤΗΝ ΠΑΡΑΓΩΓΗ ΜΟΝΟΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ ΟΙ ΟΠΟΙΟΙ ΧΡΗΣΙΜΟΠΟΙΟΥΝΤΑΙ ΓΙΑ ΤΗΝ ΤΥΠΟΠΟΙΗΣΗ 40 ΣΤΕΛΕΧΩΝ ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ ΜΕ ΤΗΝ ΜΕΘΟΔΟ ELISA. Η ΠΡΟΕΛΕΥΣΗ ΤΩΝ ΣΤΕΛΕΧΩΝ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΤΗΣ ΤΥΠΟΠΟΙΗΣΗΣ ΚΑΘΩΣ ΚΑΙ Η ΕΠΙΒΕΒΑΙΩΣΗ ΜΕ ΤΗΝ ΧΡΗΣΗ ΠΕΡΙΟΡΙΣΤΙΚΩΝ ΕΝΖΥΜΩΝ ΑΠΟΔΕΙΚΝΥΟΥΝ ΟΤΙ Η ΧΡΗΣΙΜΟΠΟΙΗΣΗ ΤΩΝ ΠΑΡΑΧΘΕΝΤΩΝ ΜΟΝΟΔΥΝΑΜΩΝ ΑΝΤΙΟΡΩΝ ΠΡΟΣΦΕΡΕΤΑΙ ΓΙΑ ΤΗΝ ΑΚΡΙΒΗ ΤΥΠΟΠΟΙΗΣΗ ΤΩΝ ΣΤΕΛΕΧΩΝ ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ. ΠΑΡΟΥΣΙΑΣΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ ΤΟΥ ΠΡΟΣΔΙΟΡΙΣΜΟΥ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΤΩΝ 2 ΤΥΠΩΝ ΤΟΥ ΙΟΥ ΚΑΘΩΣ ΚΑΙ ΣΥΓΚΡΙΤΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΤΩΝ ΑΠΟΤΕΛΕΣΜΑΤΩΝ."],"dc:identifier":["10.12681/eadd/1249","http://hdl.handle.net/10442/hedi/1249"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["ELISA","Herpes simplex virus 1","TYPING OF ISOLATED STRAINS HSV-1, HSV-2","Western blot","ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ","ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ ΤΩΝ 2 ΤΥΠΩΝ ΤΟΥ ΙΟΥ (HSV)","ΙΟΣ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ ΤΥΠΟΥ 1 ΚΑΙ 2","ΤΥΠΟΠΟΙΗΣΗ ΣΤΕΛΕΧΩΝ HSV-1 ΚΑΙ HSV-2","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["ΑΝΤΙΓΟΝΙΚΗ ΜΕΛΕΤΗ. ΤΥΠΟΠΟΙΗΣΗ ΚΑΙ ΑΝΟΣΟΕΝΖΥΜΑΤΙΚΟΣ ΕΛΕΓΧΟΣ ΕΙΔΙΚΩΝ ΑΝΤΙΣΩΜΑΤΩΝ ΕΝΑΝΤΙ ΤΩΝ ΤΥΠΩΝ 1 ΚΑΙ 2 ΤΟΥ ΙΟΥ ΤΟΥ ΑΠΛΟΥ ΕΡΠΗΤΑ (HSV)","ANTIGENIC STUDY OF HERPES SIMPLEX VIRUS TYPE 1 (HSV-1) AND TYPE 2 (HSV-2), TYPING OF ISOLATED STRAINS AND DETECTION OF TYPE SPECIFIC ANTIBODIES TO HSV-1 AND HSV-2"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:49Z"}