{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1210"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1210","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ ΘΕΡΜΙΚΟΥ ΣΟΚ ΣΕ ΜΟΛΥΣΜΕΝΑ ΚΑΙ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΑΠΟ ΤΟΝΙΟ SV40","abstract":"THE RECENT OBSERVATION THAT SOME DNA TUMOR VIRUSES INDUCE THE HEAT SHOCK PROTEINS IN THEIR HOST CELLS, WAS THE STIMULUS FOR THE STUDY OF THE ABOVE INDUCTION IN PERMISSIVE AND TRANSFORMED CELLS BY SV40 VIRUS. IT WAS SHOWN THAT PROTEINS OFTHE 70 KD FAMILY ARE INDUCED AFTER HEAT SHOCK (43 C) AND ARSENITE TREATMENT (20-25 MM) BUT THEY WERE ALSO INDUCED AFTER INFECTION OF THE CV1 CELLS WITH SV40 VIRUS. IT WAS ALSO SHOWN THAT THE ABOVE INDUCTION WAS SOMEWHAT DIFFERENT. THE GENES RESPONSIBLE FOR THE INDUCTION OF THE 70 KD FAMILY HEAT SHOCK PROTEINS WERETHE EARLY VIRAL GENES (T-ANTIGENS). THE EXPOSURE OF SV40 VIRUS INFECTED CV1 CELLS TO HEAT SHOCK OR ARSENITE RESULTED IN AN INHIBITION OF THE EARLY AND LATE VIRAL GENE EXPRESSION. THE INHIBITION OF THE LATE VIRAL GENE EXPRESSION WAS SHOWN TO TAKE PLACE AT THE TRANSCRIPTIONAL OR POST - TRANSCRIPTIONAL LEVEL. THE SAME INHIBITION WAS OBSERVED IN THE EXPRESSION OF THE ENDOGENOUS T-ANTIGEN IN TRANSFORMED COS1 CELLS AFTER HEAT SHOCK OR ARSENITE TREATMENT. IT IS POSSIBLE THAT THE DNA TUMOR VIRUSES BESIDES BEING INDUCERS OF THE HEAT SHOCK PROTEINS ARE THEMSELVES TARGET OF THE SAME PROTEINS.","abstract_html":"THE RECENT OBSERVATION THAT SOME DNA TUMOR VIRUSES INDUCE THE HEAT SHOCK PROTEINS IN THEIR HOST CELLS, WAS THE STIMULUS FOR THE STUDY OF THE ABOVE INDUCTION IN PERMISSIVE AND TRANSFORMED CELLS BY SV40 VIRUS. IT WAS SHOWN THAT PROTEINS OFTHE 70 KD FAMILY ARE INDUCED AFTER HEAT SHOCK (43 C) AND ARSENITE TREATMENT (20-25 MM) BUT THEY WERE ALSO INDUCED AFTER INFECTION OF THE CV1 CELLS WITH SV40 VIRUS. IT WAS ALSO SHOWN THAT THE ABOVE INDUCTION WAS SOMEWHAT DIFFERENT. THE GENES RESPONSIBLE FOR THE INDUCTION OF THE 70 KD FAMILY HEAT SHOCK PROTEINS WERETHE EARLY VIRAL GENES (T-ANTIGENS). THE EXPOSURE OF SV40 VIRUS INFECTED CV1 CELLS TO HEAT SHOCK OR ARSENITE RESULTED IN AN INHIBITION OF THE EARLY AND LATE VIRAL GENE EXPRESSION. THE INHIBITION OF THE LATE VIRAL GENE EXPRESSION WAS SHOWN TO TAKE PLACE AT THE TRANSCRIPTIONAL OR POST - TRANSCRIPTIONAL LEVEL. THE SAME INHIBITION WAS OBSERVED IN THE EXPRESSION OF THE ENDOGENOUS T-ANTIGEN IN TRANSFORMED COS1 CELLS AFTER HEAT SHOCK OR ARSENITE TREATMENT. IT IS POSSIBLE THAT THE DNA TUMOR VIRUSES BESIDES BEING INDUCERS OF THE HEAT SHOCK PROTEINS ARE THEMSELVES TARGET OF THE SAME PROTEINS.","abstract_has_math":false,"creators":["Angelidis, Charalambos","Αγγελίδης, Χαράλαμπος"],"institution":"University of Ioannina","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989","date_published":"1989","updated_at":"2026-07-24T02:24:46Z","subjects":["Θερμικό σοκ","Heat shock","SV40","Ιός SV40","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1210"],"render_values":[{"text":"10.12681/eadd/1210","href":"https://doi.org/10.12681/eadd/1210","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1210","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Angelidis, Charalambos","Αγγελίδης, Χαράλαμπος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989"]},{"key":"dc:publisher","label":"Institution","values":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Θερμικό σοκ","Heat shock","SV40","Ιός SV40","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1210","http://hdl.handle.net/10442/hedi/1210"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THE RECENT OBSERVATION THAT SOME DNA TUMOR VIRUSES INDUCE THE HEAT SHOCK PROTEINS IN THEIR HOST CELLS, WAS THE STIMULUS FOR THE STUDY OF THE ABOVE INDUCTION IN PERMISSIVE AND TRANSFORMED CELLS BY SV40 VIRUS. IT WAS SHOWN THAT PROTEINS OFTHE 70 KD FAMILY ARE INDUCED AFTER HEAT SHOCK (43 C) AND ARSENITE TREATMENT (20-25 MM) BUT THEY WERE ALSO INDUCED AFTER INFECTION OF THE CV1 CELLS WITH SV40 VIRUS. IT WAS ALSO SHOWN THAT THE ABOVE INDUCTION WAS SOMEWHAT DIFFERENT. THE GENES RESPONSIBLE FOR THE INDUCTION OF THE 70 KD FAMILY HEAT SHOCK PROTEINS WERETHE EARLY VIRAL GENES (T-ANTIGENS). THE EXPOSURE OF SV40 VIRUS INFECTED CV1 CELLS TO HEAT SHOCK OR ARSENITE RESULTED IN AN INHIBITION OF THE EARLY AND LATE VIRAL GENE EXPRESSION. THE INHIBITION OF THE LATE VIRAL GENE EXPRESSION WAS SHOWN TO TAKE PLACE AT THE TRANSCRIPTIONAL OR POST - TRANSCRIPTIONAL LEVEL. THE SAME INHIBITION WAS OBSERVED IN THE EXPRESSION OF THE ENDOGENOUS T-ANTIGEN IN TRANSFORMED COS1 CELLS AFTER HEAT SHOCK OR ARSENITE TREATMENT. IT IS POSSIBLE THAT THE DNA TUMOR VIRUSES BESIDES BEING INDUCERS OF THE HEAT SHOCK PROTEINS ARE THEMSELVES TARGET OF THE SAME PROTEINS.","Η ΠΡΟΣΦΑΤΗ ΠΑΡΑΤΗΡΗΣΗ ΟΤΙ ΟΡΙΣΜΕΝΟΙ DNA ΟΓΚΟΓΟΝΟΙ ΙΟΙ ΕΠΑΓΟΥΝ ΠΡΩΤΕΙΝΕΣ ΘΕΡΜΙΚΟΥ ΣΟΚ ΣΤΑ ΞΕΝΙΣΤΙΚΑ ΤΟΥΣ ΚΥΤΤΑΡΑ, ΑΠΟΤΕΛΕΣΕ ΤΟ ΕΡΕΘΙΣΜΑ ΓΙΑ ΤΗΝ ΜΕΛΕΤΗ ΤΗΣ ΕΠΑΓΩΓΗΣ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΑΥΤΩΝ ΣΤΑ ΕΠΙΤΡΕΠΤΙΚΑ ΚΑΙ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΑΠΟ ΤΟΝ ΙΟ SV40 ΚΥΤΤΑΡΑ. ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ ΠΡΩΤΕΙΝΕΣ ΤΗΣ 70 Κ ΟΙΚΟΓΕΝΕΙΑΣ ΕΠΑΓΟΝΤΑΙ ΤΟΣΟ ΑΠΟ ΤΟ ΘΕΡΜΙΚΟ ΣΟΚ (43 C) ΚΑΙ ΤΟ ΑΡΣΕΝΙΚΟ (20-25 ΜΜ) ΟΣΟ ΚΑΙ ΜΕΤΑ ΑΠΟ ΜΟΛΥΝΣΗ ΤΩΝ CV1 ΚΥΤΤΑΡΩΝ ΑΠΟ ΤΟΝ ΙΟ SV40. ΑΠΟΔΕΙΧΘΗΚΕ ΕΠΙΣΗΣ ΟΤΙ Η ΕΠΑΓΩΓΗ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΑΥΤΩΝ ΕΙΝΑΙ ΔΙΑΦΟΡΕΤΙΚΗ. ΥΠΕΥΘΥΝΑ ΓΟΝΙΔΙΑ ΓΙΑ ΤΗΝ ΕΠΑΓΩΓΗ ΠΡΩΤΕΙΝΩΝ ΘΕΡΜΙΚΟΥ ΣΟΚ ΤΗΣ 70Κ ΟΙΚΟΓΕΝΕΙΑΣ ΕΙΝΑΙ ΤΑ ΠΡΩΙΜΑ ΓΟΝΙΔΙΑ ΤΟΥ ΙΟΥ (Τ-ΑΝΤΙΓΟΝΑ). Η ΕΠΙΔΡΑΣΗ ΜΟΛΥΣΜΕΝΩΝ ΑΠΟ ΤΟΝ ΙΟ SV40 CV1 ΚΥΤΤΑΡΩΝ ΜΕ ΘΕΡΜΙΚΟ ΣΟΚ 'Η ΑΡΣΕΝΙΚΟ ΕΧΕΙ ΣΑΝ ΑΠΟΤΕΛΕΣΜΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΩΝ ΠΡΩΙΜΩΝ ΚΑΙ ΤΩΝ ΟΨΙΜΩΝ ΙΙΚΩΝ ΓΟΝΙΔΙΩΝ. Η ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΩΝ ΟΨΙΜΩΝ ΙΙΚΩΝ ΓΟΝΙΔΙΩΝ ΓΙΝΕΤΑΙ ΣΤΟ ΕΠΙΠΕΔΟ ΤΗΣ ΜΕΤΑΓΡΑΦΗΣ 'ΗΣΤΟ ΜΕΤΑ-ΜΕΤΑΓΡΑΦΙΚΟ ΕΠΙΠΕΔΟ. Η ΙΔΙΑ ΑΝΑΣΤΟΛΗ ΠΑΡΑΤΗΡΕΙΤΑΙ ΚΑΙ ΣΤΗΝ ΕΚΦΡΑΣΗ ΤΟΥ ΕΝΔΟΓΕΝΟΥΣ Τ-ΑΝΤΙΓΟΝΟΥ ΣΤΑ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ COS1 ΚΥΤΤΑΡΑ ΜΕΤΑ ΑΠΟ ΕΠΙΔΡΑΣΗ ΘΕΡΜΙΚΟΥ ΣΟΚ 'Η ΑΡΣΕΝΙΚΟΥ. ΠΙΘΑΝΟΝ ΟΙ DNA ΟΓΚΟΓΟΝΟΙ ΙΟΙ ΕΚΤΟΣ ΑΠΟ ΕΠΑΓΩΓΕΙΣ ΠΡΩΤΕΙΝΩΝ ΘΕΡΜΙΚΟΥ ΣΟΚ ΝΑ ΑΠΟΤΕΛΟΥΝ ΚΑΙ ΘΕΣΕΙΣ ΣΤΟΧΟΙ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΑΥΤΩΝ."]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ ΘΕΡΜΙΚΟΥ ΣΟΚ ΣΕ ΜΟΛΥΣΜΕΝΑ ΚΑΙ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΑΠΟ ΤΟΝΙΟ SV40","STUDY OF THE EFFECT OF HEAT SHOCK ON SV40 INFECTED AND TRANSFORMED CELLS"]}]}],"canonical_facts":{"dc:creator":["Angelidis, Charalambos","Αγγελίδης, Χαράλαμπος"],"dc:date":["1989"],"dc:description":["THE RECENT OBSERVATION THAT SOME DNA TUMOR VIRUSES INDUCE THE HEAT SHOCK PROTEINS IN THEIR HOST CELLS, WAS THE STIMULUS FOR THE STUDY OF THE ABOVE INDUCTION IN PERMISSIVE AND TRANSFORMED CELLS BY SV40 VIRUS. IT WAS SHOWN THAT PROTEINS OFTHE 70 KD FAMILY ARE INDUCED AFTER HEAT SHOCK (43 C) AND ARSENITE TREATMENT (20-25 MM) BUT THEY WERE ALSO INDUCED AFTER INFECTION OF THE CV1 CELLS WITH SV40 VIRUS. IT WAS ALSO SHOWN THAT THE ABOVE INDUCTION WAS SOMEWHAT DIFFERENT. THE GENES RESPONSIBLE FOR THE INDUCTION OF THE 70 KD FAMILY HEAT SHOCK PROTEINS WERETHE EARLY VIRAL GENES (T-ANTIGENS). THE EXPOSURE OF SV40 VIRUS INFECTED CV1 CELLS TO HEAT SHOCK OR ARSENITE RESULTED IN AN INHIBITION OF THE EARLY AND LATE VIRAL GENE EXPRESSION. THE INHIBITION OF THE LATE VIRAL GENE EXPRESSION WAS SHOWN TO TAKE PLACE AT THE TRANSCRIPTIONAL OR POST - TRANSCRIPTIONAL LEVEL. THE SAME INHIBITION WAS OBSERVED IN THE EXPRESSION OF THE ENDOGENOUS T-ANTIGEN IN TRANSFORMED COS1 CELLS AFTER HEAT SHOCK OR ARSENITE TREATMENT. IT IS POSSIBLE THAT THE DNA TUMOR VIRUSES BESIDES BEING INDUCERS OF THE HEAT SHOCK PROTEINS ARE THEMSELVES TARGET OF THE SAME PROTEINS.","Η ΠΡΟΣΦΑΤΗ ΠΑΡΑΤΗΡΗΣΗ ΟΤΙ ΟΡΙΣΜΕΝΟΙ DNA ΟΓΚΟΓΟΝΟΙ ΙΟΙ ΕΠΑΓΟΥΝ ΠΡΩΤΕΙΝΕΣ ΘΕΡΜΙΚΟΥ ΣΟΚ ΣΤΑ ΞΕΝΙΣΤΙΚΑ ΤΟΥΣ ΚΥΤΤΑΡΑ, ΑΠΟΤΕΛΕΣΕ ΤΟ ΕΡΕΘΙΣΜΑ ΓΙΑ ΤΗΝ ΜΕΛΕΤΗ ΤΗΣ ΕΠΑΓΩΓΗΣ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΑΥΤΩΝ ΣΤΑ ΕΠΙΤΡΕΠΤΙΚΑ ΚΑΙ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΑΠΟ ΤΟΝ ΙΟ SV40 ΚΥΤΤΑΡΑ. ΑΠΟΔΕΙΧΘΗΚΕ ΟΤΙ ΠΡΩΤΕΙΝΕΣ ΤΗΣ 70 Κ ΟΙΚΟΓΕΝΕΙΑΣ ΕΠΑΓΟΝΤΑΙ ΤΟΣΟ ΑΠΟ ΤΟ ΘΕΡΜΙΚΟ ΣΟΚ (43 C) ΚΑΙ ΤΟ ΑΡΣΕΝΙΚΟ (20-25 ΜΜ) ΟΣΟ ΚΑΙ ΜΕΤΑ ΑΠΟ ΜΟΛΥΝΣΗ ΤΩΝ CV1 ΚΥΤΤΑΡΩΝ ΑΠΟ ΤΟΝ ΙΟ SV40. ΑΠΟΔΕΙΧΘΗΚΕ ΕΠΙΣΗΣ ΟΤΙ Η ΕΠΑΓΩΓΗ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΑΥΤΩΝ ΕΙΝΑΙ ΔΙΑΦΟΡΕΤΙΚΗ. ΥΠΕΥΘΥΝΑ ΓΟΝΙΔΙΑ ΓΙΑ ΤΗΝ ΕΠΑΓΩΓΗ ΠΡΩΤΕΙΝΩΝ ΘΕΡΜΙΚΟΥ ΣΟΚ ΤΗΣ 70Κ ΟΙΚΟΓΕΝΕΙΑΣ ΕΙΝΑΙ ΤΑ ΠΡΩΙΜΑ ΓΟΝΙΔΙΑ ΤΟΥ ΙΟΥ (Τ-ΑΝΤΙΓΟΝΑ). Η ΕΠΙΔΡΑΣΗ ΜΟΛΥΣΜΕΝΩΝ ΑΠΟ ΤΟΝ ΙΟ SV40 CV1 ΚΥΤΤΑΡΩΝ ΜΕ ΘΕΡΜΙΚΟ ΣΟΚ 'Η ΑΡΣΕΝΙΚΟ ΕΧΕΙ ΣΑΝ ΑΠΟΤΕΛΕΣΜΑ ΤΗΝ ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΩΝ ΠΡΩΙΜΩΝ ΚΑΙ ΤΩΝ ΟΨΙΜΩΝ ΙΙΚΩΝ ΓΟΝΙΔΙΩΝ. Η ΑΝΑΣΤΟΛΗ ΤΗΣ ΕΚΦΡΑΣΗΣ ΤΩΝ ΟΨΙΜΩΝ ΙΙΚΩΝ ΓΟΝΙΔΙΩΝ ΓΙΝΕΤΑΙ ΣΤΟ ΕΠΙΠΕΔΟ ΤΗΣ ΜΕΤΑΓΡΑΦΗΣ 'ΗΣΤΟ ΜΕΤΑ-ΜΕΤΑΓΡΑΦΙΚΟ ΕΠΙΠΕΔΟ. Η ΙΔΙΑ ΑΝΑΣΤΟΛΗ ΠΑΡΑΤΗΡΕΙΤΑΙ ΚΑΙ ΣΤΗΝ ΕΚΦΡΑΣΗ ΤΟΥ ΕΝΔΟΓΕΝΟΥΣ Τ-ΑΝΤΙΓΟΝΟΥ ΣΤΑ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ COS1 ΚΥΤΤΑΡΑ ΜΕΤΑ ΑΠΟ ΕΠΙΔΡΑΣΗ ΘΕΡΜΙΚΟΥ ΣΟΚ 'Η ΑΡΣΕΝΙΚΟΥ. ΠΙΘΑΝΟΝ ΟΙ DNA ΟΓΚΟΓΟΝΟΙ ΙΟΙ ΕΚΤΟΣ ΑΠΟ ΕΠΑΓΩΓΕΙΣ ΠΡΩΤΕΙΝΩΝ ΘΕΡΜΙΚΟΥ ΣΟΚ ΝΑ ΑΠΟΤΕΛΟΥΝ ΚΑΙ ΘΕΣΕΙΣ ΣΤΟΧΟΙ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΑΥΤΩΝ."],"dc:identifier":["10.12681/eadd/1210","http://hdl.handle.net/10442/hedi/1210"],"dc:language":["gre"],"dc:publisher":["University of Ioannina","Πανεπιστήμιο Ιωαννίνων"],"dc:subject":["Θερμικό σοκ","Heat shock","SV40","Ιός SV40","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"dc:title":["ΜΕΛΕΤΗ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΟΥ ΘΕΡΜΙΚΟΥ ΣΟΚ ΣΕ ΜΟΛΥΣΜΕΝΑ ΚΑΙ ΜΕΤΑΣΧΗΜΑΤΙΣΜΕΝΑ ΑΠΟ ΤΟΝΙΟ SV40","STUDY OF THE EFFECT OF HEAT SHOCK ON SV40 INFECTED AND TRANSFORMED CELLS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:46Z"}