ΜΟΡΦΟΛΟΓΙΚΗ ΚΑΙ ΑΝΟΣΟΙΣΤΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΤΗΣ ΝΟΣΟΥ ΤΟΥ HODGKIN, ΣΥΓΚΡΙΤΙΚΗ ΣΤΙΣ ΔΙΑΦΟΡΕΣ ΜΟΡΦΕΣ
FORTY-TWO CASES OF HODGKIN'S DISEASE WERE STUDIED MORPHOLOGICALLY AND IMMUNOHISTOCHEMICALLY BY USING MONOCLONAL ANTIBODIES MAINLY AGAINST KI-1, LEUM1, EMA, LCA, L26 AND VCHL1. NO SIMILAR STUDY HAS BEEN DONE PREVIOUSLY IN GREECE. THE WHOLE NUMBER OF STUDIES APPLIED IN B-CELL MARKERS ON LYMPHOCYTE PREDOMINANT HODGKIN'S DISEASE IS ALSO VERY LIMITED. ALL OF THEM WERE DONE ON PARAFFIN SECTIONS. INOUR PRESENT STUDY CRYOSTAT SECTIONS WERE ADDITIONALLY USED IN PART OF THE CASES. THE USE OF L26, A PAN B-ANTIGEN, HAS BEEN RECENTLY INTRODUCED IN IMMUNOHISTOPATHOLOGY. OUR STUDY WAS THE FIRST TO APPLIED THIS ANTIGEN IN IMMUNOHISTOCHEMICAL EVALUATION AND IDENTIFICATION OF THE NEOPLASTIC CELLS IN LYMPHOCYTE PREDOMINANT TYPE. IT IS CONCLUDED THAT SOME MORPHOLOGICAL AND IMMUNOHISTOCHEMICAL FEATURES DO EXIST, HELPING WITH THE PREDICTION OF THE POSSIBLE PROGRESSION OF THE LYMPHOCYTE PREDOMINANT HODGKIN'S DISEASE TOWARD A HIGH GRADE MALIGNANT LYMPHOMA. THE INCLUDED AGGREGATION OF L AND H CELLS INTERMINGLED WITH CELLS OF CENTROBLASTIC AND/OR IMMUNOBLASTIC TYPE AS WELL AS NEGATIVITY FOR LEUM1 AND KI-1 AND POSITIVITY FOR L26 AND LCA ANTIGENS. NEGATIVITY FOR KI-1 ANTIGEN IN PARAFFIN SECTIONS MUST BE ACCEPTED WITH RESERVE IMMUNOHISTOCHEMICAL IDENTIFICATION OF KI-1 PHENOTYPE OF NEOPLASTIC CELLS IN LYMPHOCYTE PREDOMINANT TYPE DEMANDS THE USAGE OF CRYOSTAT SECTIONS.
ΛΕΜΦΟΕΠΙΚΡΑΤΙΚΟΣ ΤΥΠΟΣ (ΟΖΩΔΗΣ, ΔΙΑΧΥΤΟΣ), Νόσος Hodgkin, Hodgkin's disease, LYMPHOCYTE PREDOMINANT TYPE (NODULAR, DIFFUSE), Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine
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