ΣΥΝΘΕΣΗ ΚΑΙ ΦΑΡΜΑΚΟΧΗΜΙΚΗ ΜΕΛΕΤΗ ΜΕΡΙΚΩΝ ΥΠΟΚΑΤΕΣΤΗΜΕΝΩΝ 2'-ΥΔΡΟΞΥ- ΑΙΘΥΛ-ΑΜΙΝΟ'Η ΔΙΑΜΙΝΟ-ΒΟΥΤΥΡΟ-ΚΕΤΟΝΩΝ ΜΕ ΒΙΟΛΟΓΙΚΟ ΕΝΔΙΑΦΕΡΟΝ

A NUMBER OF NEW Γ-(2'-HYDROXY-)-AMINO-KETONES ARE SYNTHESIZED AND THE IMPORTANCE OF VARIOUS EFFECTS ON THE FORMATION OF THE CLOSED, (N,O),(N,N) SYSTEM IS STUDIED. IONIZATION CONSTANTS (PKA'S) AND PARTITION COEFFICIENTS (N-OCTANOL-W OF THE SYNTHESIZED COMPOUNDS ARE DETERMINED EXPERIMENTALLY AND PREDICTED USING THE APPROPRIATE TAFT EQUATIONS AND REKKER'S HYDROPHOBIC FRAGMENTAL CONSTANT SYSTEM. THE VALUES OF THE TWO ABOVE MENTIONED PHYSICOCHEMICAL PARAMETERS AND THE RELIABILITY OF THE PREDICTIVE METHODS ARE DISCUSSED. THE LETHAL DOSES (RATS) OF THE DERIVATIVES ARE FOUND. THE ANTIINFLAMMATORY AND OR IMMUNOSUPPRESSIVE ACTIVITY INVIVO AND IN VITRO HAS BEEN CONDUCTED AND FOR THESE THE ADJUVANT INDUCED DISEASE (ARTHRITIS) AID MODEL HAS BEEN USED. A PERIPHERAL ANALGESIC ACTIVITY (WRITHING TEST) BY THE ARYL-AMINO- KETONES IN RATS IS DETERMINED. AN ATTEMPT IS MADE TOCORRELATE STRUCTURE, PHYSICOCHEMICAL PROPERTIES/BIOLOGIC ACTIVITY.

Grantor dc:publisher

Aristotle University Of Thessaloniki (AUTH)

Year dc:date

1989

Authors dc:creator

• Χατζηπαύλου, Δήμητρα
• Hadjipavlou-Litina, Dimitra

• ΑΝΑΛΓΗΤΙΚΗ ΠΕΡΙΦΕΡΙΚΗ ΔΡΑΣΗ
• ΑΝΟΣΟΕΝΙΣΧΥΤΙΚΟ ΤΟΥ FREUND(AID)
• ΑΝΤΙΦΛΕΓΜΟΝΩΔΗΣ/ΑΝΟΣΟΚΑΤΑΣΤΑΛΤΙΚΗ ΔΡΑΣΗ
• Διαγνωστική
• ΠΡΟΒΛΕΨΕΙΣ, ΜΗ ΣΤΕΡΟΕΙΔΗ ΑΝΤΙΦΛΕΓΜΟΝΩΔΗ
• ΣΤΑΘΕΡΑ ΙΟΝΙΣΜΟΥ, ΣΥΝΤΕΛΕΣΤΗΣ ΚΑΤΑΝΟΜΗΣ
• Σύνθεση
• ΥΔΡΟΞΥ-ΑΙΘΥΛ-ΑΜΙΝΟ 'Η ΔΙΑΜΙΝΟ-ΒΟΥΤΥΡΟ-ΚΕΤΟΝΕΣ
• Φαρμακολογία
• Φλεγμονές
• ADJUVANT INDUCED ARTHRITIS (AID)
• ANALGESIC PERIPHERAL ACTIVITY
• ANTIINFLAMMATORY/IMMUNOSUPPRESSIVE ACTIVITY
• Diagnosis
• HYDROXY-ETHYL-AMINO OR DIAMINO-BUTYRO-KETONES
• Inflamations
• IONIZATION CONSTANT, PARTITION COEFFICIENT
• PHARMACOLOGICAL SCIENCES
• PREDICTIONS, NON STEROIDAL ANTIINFLAMMATORIES
• Synthesis
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/1186

OAI identifier oai:identifier

oai:10442/1186