{"id":{"repo_id":"greece","oai_identifier":"oai:10442/1050"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/1050","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΤΩΝ ΜΕΤΑΒΟΛΩΝ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΠΛΗΘΥΣΜΩΝ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΛΕΜΦΟΚΙΝΩΝΣΕ ΑΡΡΩΣΤΟΥΣ ΜΕ ΑΠΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ ΜΕΤΑ ΑΠΟ ΘΕΡΑΠΕΙΑ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ","abstract":"TWENTY-TWO PATIENTS WITH APLASTIC ANEMIA WERE ANALYSED BEFORE AND AFTER THERAPYWITH ANTITHYMOCYTE GLOBULIN. LYMPHOTYPE, LYMPHOKINE PRODUCTION AND HEMATOPOIETIC CELL NUMBER WERE MEASURED BEFORE AND 3 MONTHS AFTER THERAPY. IN ALL HEMATOLOGIC RESPONDERS THE NUMBER OF TAC+ LYMPHOCYTES AFTER ATG THERAPY WAS IN THE NORMAL RANGE, BUT HALF OF THE 12 NON-RESPONDING PATIENTS CONTINUED TO HAVE ABNORMALLY ELEVATED IN ALMOST HALF OF THE APLASTIC PATIENTS BEFORE TREATMENT. AFTER TREATMENT ONLY 3 PATIENTS CONTINUED TO HAVE DETECTABLE LEVELS. THESE RESULTS SUGGEST THAT THE TARGET OF ATG THERAPY MAY BE A TAC+ T-LYMPHOCYTE .","abstract_html":"TWENTY-TWO PATIENTS WITH APLASTIC ANEMIA WERE ANALYSED BEFORE AND AFTER THERAPYWITH ANTITHYMOCYTE GLOBULIN. LYMPHOTYPE, LYMPHOKINE PRODUCTION AND HEMATOPOIETIC CELL NUMBER WERE MEASURED BEFORE AND 3 MONTHS AFTER THERAPY. IN ALL HEMATOLOGIC RESPONDERS THE NUMBER OF TAC+ LYMPHOCYTES AFTER ATG THERAPY WAS IN THE NORMAL RANGE, BUT HALF OF THE 12 NON-RESPONDING PATIENTS CONTINUED TO HAVE ABNORMALLY ELEVATED IN ALMOST HALF OF THE APLASTIC PATIENTS BEFORE TREATMENT. AFTER TREATMENT ONLY 3 PATIENTS CONTINUED TO HAVE DETECTABLE LEVELS. THESE RESULTS SUGGEST THAT THE TARGET OF ATG THERAPY MAY BE A TAC+ T-LYMPHOCYTE .","abstract_has_math":false,"creators":["Πλατανιάς, Λεωνίδας"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1989,"date_issued":"1989","date_published":"1989","updated_at":"2026-07-24T02:24:43Z","subjects":["ANTITHYMOCYTE-GLOBULIN","Aplastic Anemia","Hematopoiesis","Immunosuppression","Interferon","Interleukin-2","LIMPHOKINES","Lymphocytes","Αιματοποίηση","Ανοσοκαταστολή","ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ","Απλαστική αναιμία","Ιντερλευκίνη-2","Ιντερφερόνες","ΛΕΜΦΟΚΙΝΕΣ","Λεμφοκύτταρα","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1050"],"render_values":[{"text":"10.12681/eadd/1050","href":"https://doi.org/10.12681/eadd/1050","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/1050","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Πλατανιάς, Λεωνίδας"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1989"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ANTITHYMOCYTE-GLOBULIN","Aplastic Anemia","Hematopoiesis","Immunosuppression","Interferon","Interleukin-2","LIMPHOKINES","Lymphocytes","Αιματοποίηση","Ανοσοκαταστολή","ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ","Απλαστική αναιμία","Ιντερλευκίνη-2","Ιντερφερόνες","ΛΕΜΦΟΚΙΝΕΣ","Λεμφοκύτταρα","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/1050","http://hdl.handle.net/10442/hedi/1050"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["TWENTY-TWO PATIENTS WITH APLASTIC ANEMIA WERE ANALYSED BEFORE AND AFTER THERAPYWITH ANTITHYMOCYTE GLOBULIN. LYMPHOTYPE, LYMPHOKINE PRODUCTION AND HEMATOPOIETIC CELL NUMBER WERE MEASURED BEFORE AND 3 MONTHS AFTER THERAPY. IN ALL HEMATOLOGIC RESPONDERS THE NUMBER OF TAC+ LYMPHOCYTES AFTER ATG THERAPY WAS IN THE NORMAL RANGE, BUT HALF OF THE 12 NON-RESPONDING PATIENTS CONTINUED TO HAVE ABNORMALLY ELEVATED IN ALMOST HALF OF THE APLASTIC PATIENTS BEFORE TREATMENT. AFTER TREATMENT ONLY 3 PATIENTS CONTINUED TO HAVE DETECTABLE LEVELS. THESE RESULTS SUGGEST THAT THE TARGET OF ATG THERAPY MAY BE A TAC+ T-LYMPHOCYTE .","22 ΑΡΡΩΣΤΟΙ ΜΕ ΑΠΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ ΑΝΑΛΥΘΗΚΑΝ ΠΡΙΝ ΚΑΙ ΜΕΤΑ ΤΗΝ ΘΕΡΑΠΕΙΑ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ. Ο ΛΕΜΦΟΚΥΤΤΑΡΙΚΟΣ ΦΑΙΝΟΤΥΠΟΣ, ΤΑ ΕΠΙΠΕΔΑ ΛΕΜΦΟΚΙΝΩΝ ΚΑΙ Ο ΑΡΙΘΜΟΣ ΤΩΝ ΑΡΧΕΓΟΝΩΝ ΑΙΜΟΠΟΙΗΤΙΚΩΝ ΚΥΤΤΑΡΩΝ ΜΕΤΡΗΘΗΚΑΝ ΠΡΙΝ ΚΑΙ 3 ΜΗΝΕΣ ΜΕΤΑΤΗΝ ΘΕΡΑΠΕΙΑ. ΣΕ ΟΛΟΥΣ ΤΟΥΣ ΑΝΤΑΠΟΚΡΙΘΕΝΤΕΣ ΣΤΗΝ ΘΕΡΑΠΕΙΑ ΑΣΘΕΝΕΙΣ, Ο ΑΡΙΘΜΟΣ ΤΩΝ TAC+ ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΗΤΑΝ ΣΕ ΦΥΣΙΟΛΟΓΙΚΑ ΕΠΙΠΕΔΑ ΜΕΤΑ ΑΠΟ ΤΗΝ ΘΕΡΑΠΕΙΑ ΜΕ ATG, ΑΛΛΑ ΟΙ ΜΙΣΟΙ ΑΠΟ ΤΟΥΣ 12 ΜΗ ΑΝΤΑΠΟΚΡΙΘΕΝΤΕΣ ΑΣΘΕΝΕΙΣ ΕΞΑΚΟΛΟΥΘΗΣΑΝ ΝΑ ΕΧΟΥΝ ΥΨΗΛΑ ΕΠΙΠΕΔΑ TAC+ Τ-ΛΕΜΦΟΚΥΤΤΑΡΩΝ. ΤΑ ΕΠΙΠΕΔΑ Γ-ΙΝΤΕΡΦΕΡΟΝΗΣ ΗΤΑΝ ΑΥΞΗΜΕΝΑ ΣΕ ΣΧΕΔΟΝ ΜΙΣΟΥΣ ΑΠΟ ΤΟΥΣ ΑΠΛΑΣΤΙΚΟΥΣ ΑΣΘΕΝΕΙΣ. ΜΕΤΑ ΤΗΝ ΘΕΡΑΠΕΙΑ ΜΟΝΟ 3 ΑΣΘΕΝΕΙΣ ΣΥΝΕΧΙΣΑΝ ΝΑ ΕΧΟΥΝ ΑΝΙΧΝΕΥΣΙΜΑ ΕΠΙΠΕΔΑ ΙΝΤΕΡΦΕΡΟΝΗΣ. ΑΥΤΑ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΠΡΟΤΕΙΝΟΥΝ ΟΤΙ Ο ΣΤΟΧΟΣ ΤΗΣ ΘΕΡΑΠΕΙΑΣ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ ΜΠΟΡΕΙ ΝΑ ΕΙΝΑΙ ΤΟ TAC+ ΛΕΜΦΟΚΥΤΤΑΡΟ."]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΤΩΝ ΜΕΤΑΒΟΛΩΝ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΠΛΗΘΥΣΜΩΝ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΛΕΜΦΟΚΙΝΩΝΣΕ ΑΡΡΩΣΤΟΥΣ ΜΕ ΑΠΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ ΜΕΤΑ ΑΠΟ ΘΕΡΑΠΕΙΑ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ","STUDY OF THE CHANGES OF LYMPHOCYTE PHENOTYPE AND LYMPHOKINE PRODUCTION IN PATIENTS WITH APLASTIC ANEMIA AFTER THERAPY WITH ANTITHYMOCYTE GLOBULIN"]}]}],"canonical_facts":{"dc:creator":["Πλατανιάς, Λεωνίδας"],"dc:date":["1989"],"dc:description":["TWENTY-TWO PATIENTS WITH APLASTIC ANEMIA WERE ANALYSED BEFORE AND AFTER THERAPYWITH ANTITHYMOCYTE GLOBULIN. LYMPHOTYPE, LYMPHOKINE PRODUCTION AND HEMATOPOIETIC CELL NUMBER WERE MEASURED BEFORE AND 3 MONTHS AFTER THERAPY. IN ALL HEMATOLOGIC RESPONDERS THE NUMBER OF TAC+ LYMPHOCYTES AFTER ATG THERAPY WAS IN THE NORMAL RANGE, BUT HALF OF THE 12 NON-RESPONDING PATIENTS CONTINUED TO HAVE ABNORMALLY ELEVATED IN ALMOST HALF OF THE APLASTIC PATIENTS BEFORE TREATMENT. AFTER TREATMENT ONLY 3 PATIENTS CONTINUED TO HAVE DETECTABLE LEVELS. THESE RESULTS SUGGEST THAT THE TARGET OF ATG THERAPY MAY BE A TAC+ T-LYMPHOCYTE .","22 ΑΡΡΩΣΤΟΙ ΜΕ ΑΠΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ ΑΝΑΛΥΘΗΚΑΝ ΠΡΙΝ ΚΑΙ ΜΕΤΑ ΤΗΝ ΘΕΡΑΠΕΙΑ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ. Ο ΛΕΜΦΟΚΥΤΤΑΡΙΚΟΣ ΦΑΙΝΟΤΥΠΟΣ, ΤΑ ΕΠΙΠΕΔΑ ΛΕΜΦΟΚΙΝΩΝ ΚΑΙ Ο ΑΡΙΘΜΟΣ ΤΩΝ ΑΡΧΕΓΟΝΩΝ ΑΙΜΟΠΟΙΗΤΙΚΩΝ ΚΥΤΤΑΡΩΝ ΜΕΤΡΗΘΗΚΑΝ ΠΡΙΝ ΚΑΙ 3 ΜΗΝΕΣ ΜΕΤΑΤΗΝ ΘΕΡΑΠΕΙΑ. ΣΕ ΟΛΟΥΣ ΤΟΥΣ ΑΝΤΑΠΟΚΡΙΘΕΝΤΕΣ ΣΤΗΝ ΘΕΡΑΠΕΙΑ ΑΣΘΕΝΕΙΣ, Ο ΑΡΙΘΜΟΣ ΤΩΝ TAC+ ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΗΤΑΝ ΣΕ ΦΥΣΙΟΛΟΓΙΚΑ ΕΠΙΠΕΔΑ ΜΕΤΑ ΑΠΟ ΤΗΝ ΘΕΡΑΠΕΙΑ ΜΕ ATG, ΑΛΛΑ ΟΙ ΜΙΣΟΙ ΑΠΟ ΤΟΥΣ 12 ΜΗ ΑΝΤΑΠΟΚΡΙΘΕΝΤΕΣ ΑΣΘΕΝΕΙΣ ΕΞΑΚΟΛΟΥΘΗΣΑΝ ΝΑ ΕΧΟΥΝ ΥΨΗΛΑ ΕΠΙΠΕΔΑ TAC+ Τ-ΛΕΜΦΟΚΥΤΤΑΡΩΝ. ΤΑ ΕΠΙΠΕΔΑ Γ-ΙΝΤΕΡΦΕΡΟΝΗΣ ΗΤΑΝ ΑΥΞΗΜΕΝΑ ΣΕ ΣΧΕΔΟΝ ΜΙΣΟΥΣ ΑΠΟ ΤΟΥΣ ΑΠΛΑΣΤΙΚΟΥΣ ΑΣΘΕΝΕΙΣ. ΜΕΤΑ ΤΗΝ ΘΕΡΑΠΕΙΑ ΜΟΝΟ 3 ΑΣΘΕΝΕΙΣ ΣΥΝΕΧΙΣΑΝ ΝΑ ΕΧΟΥΝ ΑΝΙΧΝΕΥΣΙΜΑ ΕΠΙΠΕΔΑ ΙΝΤΕΡΦΕΡΟΝΗΣ. ΑΥΤΑ ΤΑ ΑΠΟΤΕΛΕΣΜΑΤΑ ΠΡΟΤΕΙΝΟΥΝ ΟΤΙ Ο ΣΤΟΧΟΣ ΤΗΣ ΘΕΡΑΠΕΙΑΣ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ ΜΠΟΡΕΙ ΝΑ ΕΙΝΑΙ ΤΟ TAC+ ΛΕΜΦΟΚΥΤΤΑΡΟ."],"dc:identifier":["10.12681/eadd/1050","http://hdl.handle.net/10442/hedi/1050"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["ANTITHYMOCYTE-GLOBULIN","Aplastic Anemia","Hematopoiesis","Immunosuppression","Interferon","Interleukin-2","LIMPHOKINES","Lymphocytes","Αιματοποίηση","Ανοσοκαταστολή","ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ","Απλαστική αναιμία","Ιντερλευκίνη-2","Ιντερφερόνες","ΛΕΜΦΟΚΙΝΕΣ","Λεμφοκύτταρα","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["ΜΕΛΕΤΗ ΤΩΝ ΜΕΤΑΒΟΛΩΝ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΙΚΩΝ ΠΛΗΘΥΣΜΩΝ ΚΑΙ ΤΗΣ ΠΑΡΑΓΩΓΗΣ ΛΕΜΦΟΚΙΝΩΝΣΕ ΑΡΡΩΣΤΟΥΣ ΜΕ ΑΠΛΑΣΤΙΚΗ ΑΝΑΙΜΙΑ ΜΕΤΑ ΑΠΟ ΘΕΡΑΠΕΙΑ ΜΕ ΑΝΤΙΘΥΜΟΚΥΤΤΑΡΙΚΗ ΣΦΑΙΡΙΝΗ","STUDY OF THE CHANGES OF LYMPHOCYTE PHENOTYPE AND LYMPHOKINE PRODUCTION IN PATIENTS WITH APLASTIC ANEMIA AFTER THERAPY WITH ANTITHYMOCYTE GLOBULIN"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:24:43Z"}