{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0824"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0824","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ","abstract":"THE COMPOUNDS HERE PREPARED ARE STEROIDAL ESTERS OF N,N-BIS (2- CHLOROETHYL)ANILI WITH SEVERAL OF THE STEROIDS MODIFIED TO THE A OR D LACTAMS BEFORE ESTERIFICATION. SIXTEEN COMPOUNDS WITH POSSIBLE CYTOSTATIC ACTIVITY WERE PREPARED BY TWODIFFERENT METHODS. THE ALHYLATING AGENTS USED WERE THE MUSTARDS OF PHENYLOCETIC, PHENOXYACETIC, PHENYLBUTYRIC AND BENZOIC ACID RESPECTIVELY, AND THE STEROIDAL ALCOHOLS WERE EPI-ANDROSTERONE, CIS ANDROSTERONE, DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.","abstract_html":"THE COMPOUNDS HERE PREPARED ARE STEROIDAL ESTERS OF N,N-BIS (2- CHLOROETHYL)ANILI WITH SEVERAL OF THE STEROIDS MODIFIED TO THE A OR D LACTAMS BEFORE ESTERIFICATION. SIXTEEN COMPOUNDS WITH POSSIBLE CYTOSTATIC ACTIVITY WERE PREPARED BY TWODIFFERENT METHODS. THE ALHYLATING AGENTS USED WERE THE MUSTARDS OF PHENYLOCETIC, PHENOXYACETIC, PHENYLBUTYRIC AND BENZOIC ACID RESPECTIVELY, AND THE STEROIDAL ALCOHOLS WERE EPI-ANDROSTERONE, CIS ANDROSTERONE, DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.","abstract_has_math":false,"creators":["Πάϊρας, Γιώργος"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:27Z","subjects":["{ΕΣΤΕΡΟΠΟΙΗΣΗ ΜΕ} ΔΙΚΥΚΛΟΕΞΥΛΚΑΡΙΞΟΔΙΙΜΙΔΙΟ","Αλκυλιωτικοί παράγοντες","ΜΟΥΣΤΑΡΔΑ ΤΟΥ ΦΑΙΝΟΞΥΟΞΙΚΟΥ ΟΞΕΟΣ","ΜΟΥΣΤΑΡΔΑ ΤΟΥ ΦΑΙΝΥΛΟΞΙΚΟΥ ΟΞΕΟΣ","Μουστάρδές αζώτου","ΝΟΡ-ΣΤΕΡΟΕΙΔΕΣ","Ομο αζωτουχα στεροειδή","ΤΡΟΠΟΠΟΙΗΜΕΝΟΙ ΣΤΕΡΟΕΙΔΕΙΣ ΕΣΤΕΡΕΣ","Χημειοθεραπεία","Χλωραμπουκίλη","Alkylating agents","Chemotherapy","Chlorambucil","DICYCLOHEXYLCARBODIIMIDE {ESTERIFICATION WITH}","MODIFIED STEROIDAL ESTERS","Nitrogen mustards","NOR-STEROID","Omo-aza steroids","PHENOXYACETIC ACID {MUSTARD OF}","PHENYLACETIC ACID {MUSTARD OF}","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0824"],"render_values":[{"text":"10.12681/eadd/0824","href":"https://doi.org/10.12681/eadd/0824","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0824","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Πάϊρας, Γιώργος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["{ΕΣΤΕΡΟΠΟΙΗΣΗ ΜΕ} ΔΙΚΥΚΛΟΕΞΥΛΚΑΡΙΞΟΔΙΙΜΙΔΙΟ","Αλκυλιωτικοί παράγοντες","ΜΟΥΣΤΑΡΔΑ ΤΟΥ ΦΑΙΝΟΞΥΟΞΙΚΟΥ ΟΞΕΟΣ","ΜΟΥΣΤΑΡΔΑ ΤΟΥ ΦΑΙΝΥΛΟΞΙΚΟΥ ΟΞΕΟΣ","Μουστάρδές αζώτου","ΝΟΡ-ΣΤΕΡΟΕΙΔΕΣ","Ομο αζωτουχα στεροειδή","ΤΡΟΠΟΠΟΙΗΜΕΝΟΙ ΣΤΕΡΟΕΙΔΕΙΣ ΕΣΤΕΡΕΣ","Χημειοθεραπεία","Χλωραμπουκίλη","Alkylating agents","Chemotherapy","Chlorambucil","DICYCLOHEXYLCARBODIIMIDE {ESTERIFICATION WITH}","MODIFIED STEROIDAL ESTERS","Nitrogen mustards","NOR-STEROID","Omo-aza steroids","PHENOXYACETIC ACID {MUSTARD OF}","PHENYLACETIC ACID {MUSTARD OF}","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0824","http://hdl.handle.net/10442/hedi/0824"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THE COMPOUNDS HERE PREPARED ARE STEROIDAL ESTERS OF N,N-BIS (2- CHLOROETHYL)ANILI WITH SEVERAL OF THE STEROIDS MODIFIED TO THE A OR D LACTAMS BEFORE ESTERIFICATION. SIXTEEN COMPOUNDS WITH POSSIBLE CYTOSTATIC ACTIVITY WERE PREPARED BY TWODIFFERENT METHODS. THE ALHYLATING AGENTS USED WERE THE MUSTARDS OF PHENYLOCETIC, PHENOXYACETIC, PHENYLBUTYRIC AND BENZOIC ACID RESPECTIVELY, AND THE STEROIDAL ALCOHOLS WERE EPI-ANDROSTERONE, CIS ANDROSTERONE, DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.","ΟΙ ΕΝΩΣΕΙΣ ΔΠΟΥ ΠΑΡΑΣΚΕΥΑΣΤΗΚΑΝ ΣΤΗΝ ΠΑΡΟΥΣΑ ΕΡΓΑΣΙΑ ΕΙΝΑΙ ΣΤΕΡΟΕΙΔΕΙΣ ΕΣΤΕΡΕΣ ΤΗΣ Ν,Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΜΕ ΤΑ ΠΕΡΙΣΣΟΤΕΡΑ ΣΤΕΡΟΕΙΔΗ ΤΡΟΠΟΠΟΙΗΜΕΝΑ ΠΡΟΣ ΤΙΣ Α ΚΑΙ D ΛΑΚΤΑΜΕΣ ΠΡΙΝ ΤΗΝ ΕΣΤΕΡΟΠΟΙΗΣΗ. ΔΕΚΑΕΞΙ ΠΡΟΙΟΝΤΑ ΜΕ ΠΙΘΑΝΗ ΚΥΤΤΑΡΟΣΤΑΤΙΚΗ ΔΡΑΣΗ ΠΑΡΑΣΚΕΥΑΣΤΗΚΑΝ ΜΕ ΔΥΟΔΙΑΦΟΡΕΤΙΚΕΣ ΜΕΘΟΔΟΥΣ. ΟΙ ΑΛΚΥΛΙΩΤΙΚΟΙ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΗΤΑΝ ΟΙ ΜΟΥΣΤΑΡΔΕΣ ΤΟΥ ΦΑΙΝΥΛΟΞΙΚΟΥ, ΦΑΙΝΟΞΥΟΞΙΚΟΥ, ΦΑΙΝΥΛΟΒΟΥΤΥΡΙΚΟΥ ΚΑΙ (Κ- ΒΕΝΖΟΙΚΟΥ ΟΞΕΟΣ, ΕΝΩ ΤΑ ΣΤΕΡΟΕΙΔΗ (ΑΛΚΟΟΛΕΣ) ΗΤΑΝ ΗΕΠΙ- ΑΝΔΡΟΣΤΕΡΟΝΗ, Η CIS-ΑΝΔΡΟΣΤΕΡΟΝΗ, Η ΔΕΥΔΡΟ-ΕΠΙ-ΑΝΔΡΟΣΤΕΡΟΝΗ, Η ΤΕΣΤΟΣΤΕΡΟΝΗ, Η ΟΙΣΤΡΟΝΗ Η ΠΡΕΓΝΕΤΟΞΟΝΗ ΚΑΙ Η ΑΝΔΡΟΣΤΑΝΟΞΟΝΗ."]},{"key":"dc:title","label":"Title","values":["ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ","SYNTHESIS AND BIOLOGICAL ACTIVITY OF MODIFIED STEROIDAL ESTERS WITH N, N-BIS(2-CHLOROETHYL)ANILINE DERIVATIES"]}]}],"canonical_facts":{"dc:creator":["Πάϊρας, Γιώργος"],"dc:date":["1987"],"dc:description":["THE COMPOUNDS HERE PREPARED ARE STEROIDAL ESTERS OF N,N-BIS (2- CHLOROETHYL)ANILI WITH SEVERAL OF THE STEROIDS MODIFIED TO THE A OR D LACTAMS BEFORE ESTERIFICATION. SIXTEEN COMPOUNDS WITH POSSIBLE CYTOSTATIC ACTIVITY WERE PREPARED BY TWODIFFERENT METHODS. THE ALHYLATING AGENTS USED WERE THE MUSTARDS OF PHENYLOCETIC, PHENOXYACETIC, PHENYLBUTYRIC AND BENZOIC ACID RESPECTIVELY, AND THE STEROIDAL ALCOHOLS WERE EPI-ANDROSTERONE, CIS ANDROSTERONE, DEHYDRO-EPI-ANDROSTERONE, TESTOSTERONE, ESTRONE, PREGNENOLONE AND ANDROSTANALONE.","ΟΙ ΕΝΩΣΕΙΣ ΔΠΟΥ ΠΑΡΑΣΚΕΥΑΣΤΗΚΑΝ ΣΤΗΝ ΠΑΡΟΥΣΑ ΕΡΓΑΣΙΑ ΕΙΝΑΙ ΣΤΕΡΟΕΙΔΕΙΣ ΕΣΤΕΡΕΣ ΤΗΣ Ν,Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΜΕ ΤΑ ΠΕΡΙΣΣΟΤΕΡΑ ΣΤΕΡΟΕΙΔΗ ΤΡΟΠΟΠΟΙΗΜΕΝΑ ΠΡΟΣ ΤΙΣ Α ΚΑΙ D ΛΑΚΤΑΜΕΣ ΠΡΙΝ ΤΗΝ ΕΣΤΕΡΟΠΟΙΗΣΗ. ΔΕΚΑΕΞΙ ΠΡΟΙΟΝΤΑ ΜΕ ΠΙΘΑΝΗ ΚΥΤΤΑΡΟΣΤΑΤΙΚΗ ΔΡΑΣΗ ΠΑΡΑΣΚΕΥΑΣΤΗΚΑΝ ΜΕ ΔΥΟΔΙΑΦΟΡΕΤΙΚΕΣ ΜΕΘΟΔΟΥΣ. ΟΙ ΑΛΚΥΛΙΩΤΙΚΟΙ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΗΤΑΝ ΟΙ ΜΟΥΣΤΑΡΔΕΣ ΤΟΥ ΦΑΙΝΥΛΟΞΙΚΟΥ, ΦΑΙΝΟΞΥΟΞΙΚΟΥ, ΦΑΙΝΥΛΟΒΟΥΤΥΡΙΚΟΥ ΚΑΙ (Κ- ΒΕΝΖΟΙΚΟΥ ΟΞΕΟΣ, ΕΝΩ ΤΑ ΣΤΕΡΟΕΙΔΗ (ΑΛΚΟΟΛΕΣ) ΗΤΑΝ ΗΕΠΙ- ΑΝΔΡΟΣΤΕΡΟΝΗ, Η CIS-ΑΝΔΡΟΣΤΕΡΟΝΗ, Η ΔΕΥΔΡΟ-ΕΠΙ-ΑΝΔΡΟΣΤΕΡΟΝΗ, Η ΤΕΣΤΟΣΤΕΡΟΝΗ, Η ΟΙΣΤΡΟΝΗ Η ΠΡΕΓΝΕΤΟΞΟΝΗ ΚΑΙ Η ΑΝΔΡΟΣΤΑΝΟΞΟΝΗ."],"dc:identifier":["10.12681/eadd/0824","http://hdl.handle.net/10442/hedi/0824"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["{ΕΣΤΕΡΟΠΟΙΗΣΗ ΜΕ} ΔΙΚΥΚΛΟΕΞΥΛΚΑΡΙΞΟΔΙΙΜΙΔΙΟ","Αλκυλιωτικοί παράγοντες","ΜΟΥΣΤΑΡΔΑ ΤΟΥ ΦΑΙΝΟΞΥΟΞΙΚΟΥ ΟΞΕΟΣ","ΜΟΥΣΤΑΡΔΑ ΤΟΥ ΦΑΙΝΥΛΟΞΙΚΟΥ ΟΞΕΟΣ","Μουστάρδές αζώτου","ΝΟΡ-ΣΤΕΡΟΕΙΔΕΣ","Ομο αζωτουχα στεροειδή","ΤΡΟΠΟΠΟΙΗΜΕΝΟΙ ΣΤΕΡΟΕΙΔΕΙΣ ΕΣΤΕΡΕΣ","Χημειοθεραπεία","Χλωραμπουκίλη","Alkylating agents","Chemotherapy","Chlorambucil","DICYCLOHEXYLCARBODIIMIDE {ESTERIFICATION WITH}","MODIFIED STEROIDAL ESTERS","Nitrogen mustards","NOR-STEROID","Omo-aza steroids","PHENOXYACETIC ACID {MUSTARD OF}","PHENYLACETIC ACID {MUSTARD OF}","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"dc:title":["ΣΥΝΘΕΣΗ ΤΡΟΠΟΠΟΙΗΜΕΝΩΝ ΣΤΕΡΟΕΙΔΩΝ ΕΣΤΕΡΩΝ, ΜΕ ΠΑΡΑΓΩΓΑ ΤΗΣ Ν, Ν-ΔΙΣ(2-ΧΛΩΡΟΑΙΘΥΛ)ΑΝΙΛΙΝΗΣ ΚΑΙ ΒΙΟΛΟΓΙΚΗ ΔΡΑΣΗ ΑΥΤΩΝ","SYNTHESIS AND BIOLOGICAL ACTIVITY OF MODIFIED STEROIDAL ESTERS WITH N, N-BIS(2-CHLOROETHYL)ANILINE DERIVATIES"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:27Z"}