{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0823"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0823","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΒΙΟΤΙΝΗΣ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ","abstract":"A NEW RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS IS DESCRIBED IN THIS STUDY. THE MAIN ASSAY REAGENTS ARE: A MIXTURE OF NB-(4-OH-3-125I-PHENYL)ETHYL] AND N-[B-(4-OH-3,5-DI- 125I-PHENYL)ETHYL] BIOTINAMIDES (RADIOTRACER),AVIDIN (BINDING PROTEIN), AND A DOUBLE AVIDIN ANTIBODY (SEPARATION REAGENT). THE ASSAY IS SIMPLE AND FAST (IT ALLOWS HANDLING OF >100 SAMPLES IN <4 H), REPRODUCIBLE (INTA- AND INTER ASSAY CV 41% AND 70%, RESPECTIVELY), SENSITIVE (8 NG/L), SPECIFIC AND ACCURATE (BIOTIN RECOVERY IS 90-108%). NORMAL RANGE: 100-840 NG/L. THE ASSAY WAS USED FOR THE PRELIMINARY CLINICAL EVALUATION OF SERUM SAMPLESOBTAINED FROM VARIOUS POPULATION GROUPS.","abstract_html":"A NEW RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS IS DESCRIBED IN THIS STUDY. THE MAIN ASSAY REAGENTS ARE: A MIXTURE OF NB-(4-OH-3-125I-PHENYL)ETHYL] AND N-[B-(4-OH-3,5-DI- 125I-PHENYL)ETHYL] BIOTINAMIDES (RADIOTRACER),AVIDIN (BINDING PROTEIN), AND A DOUBLE AVIDIN ANTIBODY (SEPARATION REAGENT). THE ASSAY IS SIMPLE AND FAST (IT ALLOWS HANDLING OF &gt;100 SAMPLES IN &lt;4 H), REPRODUCIBLE (INTA- AND INTER ASSAY CV 41% AND 70%, RESPECTIVELY), SENSITIVE (8 NG/L), SPECIFIC AND ACCURATE (BIOTIN RECOVERY IS 90-108%). NORMAL RANGE: 100-840 NG/L. THE ASSAY WAS USED FOR THE PRELIMINARY CLINICAL EVALUATION OF SERUM SAMPLESOBTAINED FROM VARIOUS POPULATION GROUPS.","abstract_has_math":false,"creators":["Λιβανίου, Ευαγγελία","Livaniou, Evangelia"],"institution":"Πανεπιστήμιο Πατρών","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:27Z","subjects":["125I-BIOTIN DERIVATIES","125Ι-ΠΑΡΑΓΩΓΑ ΒΙΟΤΙΝΗΣ","AVIDIN","AVIDIN-DOUBLE ANTIBODY","Biotin","BIOTIN DETERMINATION","RADIOIMMUNOASSAY","RADIOLIGAND ASSAY","ΑΒΙΔΙΝΗ","Βιοτίνη","ΔΙΠΛΟ ΑΝΤΙΣΩΜΑ ΑΒΙΔΙΝΗΣ","ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΒΙΟΤΙΝΗΣ","ΡΑΔΙΟΑΝΟΣΟΑΝΑΛΥΣΗ","ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ","Ιατρική και Επιστήμες Υγείας","Medical and Health Sciences","Βασική Ιατρική","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0823"],"render_values":[{"text":"10.12681/eadd/0823","href":"https://doi.org/10.12681/eadd/0823","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0823","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Λιβανίου, Ευαγγελία","Livaniou, Evangelia"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["Πανεπιστήμιο Πατρών","University of Patras"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["125I-BIOTIN DERIVATIES","125Ι-ΠΑΡΑΓΩΓΑ ΒΙΟΤΙΝΗΣ","AVIDIN","AVIDIN-DOUBLE ANTIBODY","Biotin","BIOTIN DETERMINATION","RADIOIMMUNOASSAY","RADIOLIGAND ASSAY","ΑΒΙΔΙΝΗ","Βιοτίνη","ΔΙΠΛΟ ΑΝΤΙΣΩΜΑ ΑΒΙΔΙΝΗΣ","ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΒΙΟΤΙΝΗΣ","ΡΑΔΙΟΑΝΟΣΟΑΝΑΛΥΣΗ","ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ","Ιατρική και Επιστήμες Υγείας","Medical and Health Sciences","Βασική Ιατρική","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0823","http://hdl.handle.net/10442/hedi/0823"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A NEW RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS IS DESCRIBED IN THIS STUDY. THE MAIN ASSAY REAGENTS ARE: A MIXTURE OF NB-(4-OH-3-125I-PHENYL)ETHYL] AND N-[B-(4-OH-3,5-DI- 125I-PHENYL)ETHYL] BIOTINAMIDES (RADIOTRACER),AVIDIN (BINDING PROTEIN), AND A DOUBLE AVIDIN ANTIBODY (SEPARATION REAGENT). THE ASSAY IS SIMPLE AND FAST (IT ALLOWS HANDLING OF >100 SAMPLES IN <4 H), REPRODUCIBLE (INTA- AND INTER ASSAY CV 41% AND 70%, RESPECTIVELY), SENSITIVE (8 NG/L), SPECIFIC AND ACCURATE (BIOTIN RECOVERY IS 90-108%). NORMAL RANGE: 100-840 NG/L. THE ASSAY WAS USED FOR THE PRELIMINARY CLINICAL EVALUATION OF SERUM SAMPLESOBTAINED FROM VARIOUS POPULATION GROUPS.","ΣΤΗΝ ΕΝ ΛΟΓΩ ΔΙΑΤΡΙΒΗ ΠΕΡΙΓΡΑΦΕΤΑΙ ΝΕΑ ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΒΙΟΤΙΝΗΣ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ. ΤΑ ΒΑΣΙΚΑ ΑΝΤΙΔΡΑΣΤΗΡΙΑ ΤΗΣ ΑΝΑΛΥΣΗΣ ΕΙΝΑΙ: ΜΙΓΜΑ Ν-[Β-(4-ΟΗ-3-125J- ΦΑΙΝΥΛΟ)ΑΙΘΥΛΟ] ΚΑΙ Ν-[Β-(4-ΟΗ-3,5-ΔΙ-125Ι-ΦΑΙΝΥΛΟ)ΑΙΘΥΛΟ] ΒΙΟΤΙΝΑΜΙΔΙΩΝ (ΡΑΔΙΟΙΧΝΗΘΕΤΗΣ), ΑΒΙΔΙΝΗ (ΕΙΔΙΚΗ ΔΕΣΜΕΥΤΙΚΗ ΠΡΩΤΕΙΝΗ) ΚΑΙ ΔΙΠΛΟ ΑΝΤΙΣΩΜΑ ΑΒΙΔΙΝΗΣ (ΑΝΤΙΔΡΑΣΤΗΡΙΟ ΔΙΑΧΩΡΙΣΜΟΥ) . Η ΑΝΑΛΥΣΗ ΕΙΝΑΙ ΑΠΛΗ ΚΑΙ ΤΑΧΕΙΑ (ΜΕΤΡΗΣΗ >100 ΔΕΙΓΜΑΤΩΝ ΣΕ <4Η), ΕΠΑΝΑΛΗΨΙΜΗ (CV ΕΝΤΟΣ ΚΑΙ ΜΕΤΑΞΥ ΜΕΤΡΗΣΕΩΝ41% ΚΑΙ 70%, ΑΝΤΙΣΤΟΙΧΑ), ΕΥΑΙΣΘΗΤΗ (8 NG/L), ΕΞΕΙΔΙΚΕΥΜΕΝΗ ΚΑΙ ΑΚΡΙΒΗΣ (ΑΝΑΚΤΗΣΗ ΒΙΟΤΙΝΗΣ 90-108%). ΦΥΣΙΟΛΟΓΙΚΗ ΠΕΡΙΟΧΗ 100-840 NG/L. Η ΑΝΑΛΥΣΗ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΕ ΓΙΑ ΤΗΝ ΠΡΟΚΑΤΑΡΚΤΙΚΗ ΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΟΡΩΝ ΑΠΟ ΔΙΑΦΟΡΕΣ ΠΛΗΘΥΣΜΙΑΚΕΣ ΟΜΑΔΕΣ."]},{"key":"dc:title","label":"Title","values":["ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΒΙΟΤΙΝΗΣ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ","RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS"]}]}],"canonical_facts":{"dc:creator":["Λιβανίου, Ευαγγελία","Livaniou, Evangelia"],"dc:date":["1987"],"dc:description":["A NEW RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS IS DESCRIBED IN THIS STUDY. THE MAIN ASSAY REAGENTS ARE: A MIXTURE OF NB-(4-OH-3-125I-PHENYL)ETHYL] AND N-[B-(4-OH-3,5-DI- 125I-PHENYL)ETHYL] BIOTINAMIDES (RADIOTRACER),AVIDIN (BINDING PROTEIN), AND A DOUBLE AVIDIN ANTIBODY (SEPARATION REAGENT). THE ASSAY IS SIMPLE AND FAST (IT ALLOWS HANDLING OF >100 SAMPLES IN <4 H), REPRODUCIBLE (INTA- AND INTER ASSAY CV 41% AND 70%, RESPECTIVELY), SENSITIVE (8 NG/L), SPECIFIC AND ACCURATE (BIOTIN RECOVERY IS 90-108%). NORMAL RANGE: 100-840 NG/L. THE ASSAY WAS USED FOR THE PRELIMINARY CLINICAL EVALUATION OF SERUM SAMPLESOBTAINED FROM VARIOUS POPULATION GROUPS.","ΣΤΗΝ ΕΝ ΛΟΓΩ ΔΙΑΤΡΙΒΗ ΠΕΡΙΓΡΑΦΕΤΑΙ ΝΕΑ ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΒΙΟΤΙΝΗΣ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ. ΤΑ ΒΑΣΙΚΑ ΑΝΤΙΔΡΑΣΤΗΡΙΑ ΤΗΣ ΑΝΑΛΥΣΗΣ ΕΙΝΑΙ: ΜΙΓΜΑ Ν-[Β-(4-ΟΗ-3-125J- ΦΑΙΝΥΛΟ)ΑΙΘΥΛΟ] ΚΑΙ Ν-[Β-(4-ΟΗ-3,5-ΔΙ-125Ι-ΦΑΙΝΥΛΟ)ΑΙΘΥΛΟ] ΒΙΟΤΙΝΑΜΙΔΙΩΝ (ΡΑΔΙΟΙΧΝΗΘΕΤΗΣ), ΑΒΙΔΙΝΗ (ΕΙΔΙΚΗ ΔΕΣΜΕΥΤΙΚΗ ΠΡΩΤΕΙΝΗ) ΚΑΙ ΔΙΠΛΟ ΑΝΤΙΣΩΜΑ ΑΒΙΔΙΝΗΣ (ΑΝΤΙΔΡΑΣΤΗΡΙΟ ΔΙΑΧΩΡΙΣΜΟΥ) . Η ΑΝΑΛΥΣΗ ΕΙΝΑΙ ΑΠΛΗ ΚΑΙ ΤΑΧΕΙΑ (ΜΕΤΡΗΣΗ >100 ΔΕΙΓΜΑΤΩΝ ΣΕ <4Η), ΕΠΑΝΑΛΗΨΙΜΗ (CV ΕΝΤΟΣ ΚΑΙ ΜΕΤΑΞΥ ΜΕΤΡΗΣΕΩΝ41% ΚΑΙ 70%, ΑΝΤΙΣΤΟΙΧΑ), ΕΥΑΙΣΘΗΤΗ (8 NG/L), ΕΞΕΙΔΙΚΕΥΜΕΝΗ ΚΑΙ ΑΚΡΙΒΗΣ (ΑΝΑΚΤΗΣΗ ΒΙΟΤΙΝΗΣ 90-108%). ΦΥΣΙΟΛΟΓΙΚΗ ΠΕΡΙΟΧΗ 100-840 NG/L. Η ΑΝΑΛΥΣΗ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΕ ΓΙΑ ΤΗΝ ΠΡΟΚΑΤΑΡΚΤΙΚΗ ΚΛΙΝΙΚΗ ΑΞΙΟΛΟΓΗΣΗ ΟΡΩΝ ΑΠΟ ΔΙΑΦΟΡΕΣ ΠΛΗΘΥΣΜΙΑΚΕΣ ΟΜΑΔΕΣ."],"dc:identifier":["10.12681/eadd/0823","http://hdl.handle.net/10442/hedi/0823"],"dc:language":["gre"],"dc:publisher":["Πανεπιστήμιο Πατρών","University of Patras"],"dc:subject":["125I-BIOTIN DERIVATIES","125Ι-ΠΑΡΑΓΩΓΑ ΒΙΟΤΙΝΗΣ","AVIDIN","AVIDIN-DOUBLE ANTIBODY","Biotin","BIOTIN DETERMINATION","RADIOIMMUNOASSAY","RADIOLIGAND ASSAY","ΑΒΙΔΙΝΗ","Βιοτίνη","ΔΙΠΛΟ ΑΝΤΙΣΩΜΑ ΑΒΙΔΙΝΗΣ","ΠΡΟΣΔΙΟΡΙΣΜΟΣ ΒΙΟΤΙΝΗΣ","ΡΑΔΙΟΑΝΟΣΟΑΝΑΛΥΣΗ","ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ","Ιατρική και Επιστήμες Υγείας","Medical and Health Sciences","Βασική Ιατρική","Basic Medicine"],"dc:title":["ΡΑΔΙΟΔΕΣΜΕΥΤΙΚΗ ΑΝΑΛΥΣΗ ΓΙΑ ΤΟΝ ΠΡΟΣΔΙΟΡΙΣΜΟ ΒΙΟΤΙΝΗΣ ΣΕ ΒΙΟΛΟΓΙΚΑ ΥΓΡΑ","RADIOLIGAND ASSAY FOR DETERMINING BIOTIN IN BIOLOGICAL FLUIDS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:27Z"}