ΣΥΜΒΟΛΗ ΣΤΗ ΜΕΛΕΤΗ ΤΩΝ ΕΠΙΔΙΟΡΘΩΤΙΚΩΝ ΜΗΧΑΝΙΣΜΩΝ ΤΟΥ DNA ΣΕ ΛΕΜΦΟΚΥΤΤΑΡΑ ΑΤΟΜΩΝ ΜΕ ΣΥΝΔΡΟΜΟ DOWN

THE CAPABILITY OF CELLS FROM CHILDREN WITH DOWN'S SYNDROME TO REPAIR X-RAY INDUCED DAMAGE IN DNA WAS STUDIED BY MEANS OF THREE DIFFERENT METHODS, NAMELY: 1) BY COUNTING SISTER CHROMATID EXCHANGES (SCE) IN NORMAL AND DOWN CELLS WHICH WEREFOUND OF SIMILAR LEVELS. IN THIS RESPECT DS RESEMBLES XERODERMA PIGMENTOSUM. 2) BY STUDYING THE DNA SEDIMENTATION PROFILES IN ALKALINE SUCROSE GRADIENTS WHICH SHOWED A LESS EFFICIENT CAPACITY OF DS LYMPHOCYTES TO REPAIR SINGLE STRAND BREAKS INDUCED BY X- RAYS. 3) BY COMPARING THE FREQUENCY OF ASYMMETRIC TO SYMMETRIC CHROMATID INTERCHANGES. THE INCREASED FREQUENCY OF INDUCED ASYMMETRIC INTERCHANGES DETECTED IN DS WAS ATTRIBUTED TO AN ALTERED WAY OF ACTION OF THE REPAIR MECHANISM OF THESE CELLS COMPARED TO THAT OF THE NORMALS.

Grantor dc:publisher

University of Patras

Year dc:date

1981

Authors dc:creator

• Athanasiou, Kyriacos
• Αθανασίου, Κυριάκος

• Ακτινοβολία - γ
• ΑΝΤΑΛΛΑΓΕΣ ΑΔΕΛΦΙΚΩΝ ΧΡΩΜΑΤΙΔΙΩΝ
• Βλάβες DNA
• Επιδιόρθωση
• ΣΥΜΜΕΤΡΙΚΕΣ-ΑΣΥΜΜΕΤΡΙΚΕΣ ΕΞΩΑΝΤΑΛΛΑΓΕΣ
• Σύνδρομο Down
• Χρωμοσώματα
• Χρωμοσωματικές μεταλλάξεις
• Chromosome aberrations
• Chromosomes
• DNA damage
• DNA-REPAIR
• Down syndrome
• Sister chromatid exchanges
• SYMMETRICAL-ASSYMETRICAL INTERCHANGES
• Γ-RADIATION
• Φυσικές Επιστήμες
• Βιολογία
• Natural Sciences
• Biological Sciences

Language dc:language

gre

Identifier

10.12681/eadd/0814

OAI identifier oai:identifier

oai:10442/0814