{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0722"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0722","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΚΑΡΔΙΑΓΓΕΙΑΚΕΣ ΜΕΤΑΒΟΛΕΣ ΑΠΟ ΤΗΝ ΕΝΑΠΟΘΕΣΗ ΝΟΡΕΠΙΝΕΦΡΙΝΗΣ ΚΑΙ ΚΛΟΝΙΔΙΝΗΣ ΣΤΟΝ ΠΥΡΗΝΑ ΤΗΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ ΤΟΥ ΠΡΟΜΗΚΗ ΜΥΕΛΟΥ ΜΗ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΩΝ ΕΠΙΜΥΩΝ ΚΑΙ Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΓΕΝΙΚΗΣ ΑΝΑΙΣΘΗΣΙΑΣ ΣΤΙΣ ΜΕΤΑΒΟΛΕΣ ΑΥΤΕΣ","abstract":"THE NUCLEUS TRACTUS SOLITARIUS (NTS) AT THE LEVEL OF THE MEDULLA OBLOCATA IS THE FIRST AND MOST IMPORTANT CENTER OF THE BARORECEPTOR REFLEX AND ONE OF THE LOCI WHERE THE CATECHOLAMINES REGULATE CENTRALLY THE LEVELS OF THE ARTERIAL BLOOD PRESSURE. PREVIOUS RESEARCH ON ANESTHETIZED ANIMALS CONCLUDED THAT LOCAL APPLICATION OF A-ADRENERGIC AGONISTS INTO THE NTS RESULTS IN HYPOTENSION AND BRADYCARDIA. HOWEVER, OUR STUDIES BASED UPON NON- ANESTHETIZED RATS, SHOWED THAT NOREPINEPHRIN LOCALLY APPLIED INTO THE NTS RESULT IN HYPERTENSION AND BRADYCARDIA. BYREPEATING THE LOCAL APPLICATION OF NOREPINEPHINE AND CLONIDINE TO RATS ANESTHETIZED WITH ETHER, URETHANE OR NEBUTAL, WE SHOWED THAT GENERAL ANESTHESIA MASKEDTHE CARDIOVASCULAR RESPONSES AND THEREFORE WE EXPLAINED OUR DIFFERENCES WITH THE PREVIOUS RESEARCHES.","abstract_html":"THE NUCLEUS TRACTUS SOLITARIUS (NTS) AT THE LEVEL OF THE MEDULLA OBLOCATA IS THE FIRST AND MOST IMPORTANT CENTER OF THE BARORECEPTOR REFLEX AND ONE OF THE LOCI WHERE THE CATECHOLAMINES REGULATE CENTRALLY THE LEVELS OF THE ARTERIAL BLOOD PRESSURE. PREVIOUS RESEARCH ON ANESTHETIZED ANIMALS CONCLUDED THAT LOCAL APPLICATION OF A-ADRENERGIC AGONISTS INTO THE NTS RESULTS IN HYPOTENSION AND BRADYCARDIA. HOWEVER, OUR STUDIES BASED UPON NON- ANESTHETIZED RATS, SHOWED THAT NOREPINEPHRIN LOCALLY APPLIED INTO THE NTS RESULT IN HYPERTENSION AND BRADYCARDIA. BYREPEATING THE LOCAL APPLICATION OF NOREPINEPHINE AND CLONIDINE TO RATS ANESTHETIZED WITH ETHER, URETHANE OR NEBUTAL, WE SHOWED THAT GENERAL ANESTHESIA MASKEDTHE CARDIOVASCULAR RESPONSES AND THEREFORE WE EXPLAINED OUR DIFFERENCES WITH THE PREVIOUS RESEARCHES.","abstract_has_math":false,"creators":["Vlahakos, Dimitrios","Βλαχάκος, Δημήτριος"],"institution":"University of Patras","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1988,"date_issued":"1988","date_published":"1988","updated_at":"2026-07-24T02:25:24Z","subjects":["ΑΙΘΕΡΑΣ","ΑΝΤΑΝΑΚΛΑΣΤΙΚΟ ΤΟΞΟ ΤΩΝ ΤΑΣΕΟΥΠΟΔΟΧΕΩΝ","Γενική αναισθησία","Κλονιδίνη","Νορεπινεφρίνη","Ουρεθάνη","ΠΕΝΤΟΒΑΡΒΙΤΑΛΗ","ΠΡΟΜΗΚΗΣ ΜΥΕΛΟΣ","ΠΥΡΗΝΑΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ","BARORECEPTOR REFLEX","Clonidine","ETHER","GENERAL ANESTHESIΑ","MEDULLA OBLOGATA","Norepinephrine","NUCLEUS TRACTUS SOLITARIUS","PENTOBARBITAL","Urethane","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0722"],"render_values":[{"text":"10.12681/eadd/0722","href":"https://doi.org/10.12681/eadd/0722","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0722","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Vlahakos, Dimitrios","Βλαχάκος, Δημήτριος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1988"]},{"key":"dc:publisher","label":"Institution","values":["University of Patras","Πανεπιστήμιο Πατρών"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΑΙΘΕΡΑΣ","ΑΝΤΑΝΑΚΛΑΣΤΙΚΟ ΤΟΞΟ ΤΩΝ ΤΑΣΕΟΥΠΟΔΟΧΕΩΝ","Γενική αναισθησία","Κλονιδίνη","Νορεπινεφρίνη","Ουρεθάνη","ΠΕΝΤΟΒΑΡΒΙΤΑΛΗ","ΠΡΟΜΗΚΗΣ ΜΥΕΛΟΣ","ΠΥΡΗΝΑΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ","BARORECEPTOR REFLEX","Clonidine","ETHER","GENERAL ANESTHESIΑ","MEDULLA OBLOGATA","Norepinephrine","NUCLEUS TRACTUS SOLITARIUS","PENTOBARBITAL","Urethane","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0722","http://hdl.handle.net/10442/hedi/0722"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THE NUCLEUS TRACTUS SOLITARIUS (NTS) AT THE LEVEL OF THE MEDULLA OBLOCATA IS THE FIRST AND MOST IMPORTANT CENTER OF THE BARORECEPTOR REFLEX AND ONE OF THE LOCI WHERE THE CATECHOLAMINES REGULATE CENTRALLY THE LEVELS OF THE ARTERIAL BLOOD PRESSURE. PREVIOUS RESEARCH ON ANESTHETIZED ANIMALS CONCLUDED THAT LOCAL APPLICATION OF A-ADRENERGIC AGONISTS INTO THE NTS RESULTS IN HYPOTENSION AND BRADYCARDIA. HOWEVER, OUR STUDIES BASED UPON NON- ANESTHETIZED RATS, SHOWED THAT NOREPINEPHRIN LOCALLY APPLIED INTO THE NTS RESULT IN HYPERTENSION AND BRADYCARDIA. BYREPEATING THE LOCAL APPLICATION OF NOREPINEPHINE AND CLONIDINE TO RATS ANESTHETIZED WITH ETHER, URETHANE OR NEBUTAL, WE SHOWED THAT GENERAL ANESTHESIA MASKEDTHE CARDIOVASCULAR RESPONSES AND THEREFORE WE EXPLAINED OUR DIFFERENCES WITH THE PREVIOUS RESEARCHES.","Ο ΠΥΡΗΝΑΣ ΤΗΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ (ΠΜΔ) ΣΤΟΝ ΠΡΟΜΗΚΗ ΜΥΕΛΟ ΕΙΝΑΙ ΤΟ ΠΡΩΤΟ ΚΑΙ ΣΠΟΥΔΑΙΟΤΕΡΟ ΚΕΝΤΡΟ ΤΟΥ ΚΑΡΔΙΑΓΓΕΙΑΚΟΥ ΑΝΤΑΝΑΚΛΑΣΤΙΚΟΥ ΤΟΞΟΥ ΤΩΝ ΤΑΣΕΟΥΠΟΔΟΧΕΩΝ, ΠΕΡΙΕΧΕΙ ΚΑΤΕΧΟΛΑΜΙΝΕΡΓΙΚΕΣ ΝΕΥΡΙΚΕΣ ΑΠΟΛΗΞΕΙΣ ΚΑΙ Α2 ΑΔΡΕΝΕΡΓΙΚΟΥΣ ΥΠΟΔΟΧΕΙΣ ΚΑΙ ΘΕΩΡΕΙΤΑΙ ΕΝΑΣ ΑΠΟ ΤΟΥΣ ΤΟΠΟΥΣ ΟΠΟΥ ΟΙ ΚΑΤΕΧΟΛΑΜΙΝΕΣ ΑΣΚΟΥΝ ΤΗΝ ΡΥΘΜΙΣΤΙΚΗ ΤΟΥΣ ΔΡΑΣΗ ΣΤΑ ΕΠΙΠΕΔΑ ΤΗΣ ΑΡΤΗΡΙΑΚΗΣ ΠΙΕΣΕΩΣ. Η ΜΕΧΡΙ ΤΩΡΑ ΕΡΕΥΝΑ, ΜΕ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΑ ΠΕΙΡΑΜΑΤΟΖΩΑ ΟΔΗΓΗΣΕ ΣΤΟ ΣΥΜΠΕΡΑΣΜΑ ΠΩΣ ΟΙ Α-ΑΔΡΕΝΕΡΓΙΚΟΙ ΔΙΕΓΕΡΤΕΣ ΧΟΡΗΓΟΥΜΕΝΟΙ ΤΟΠΙΚΑ ΣΤΟΝ ΠΜΔ ΠΡΟΚΑΛΟΥΝ ΥΠΟΤΑΣΗ ΚΑΙ ΒΡΑΔΥΚΑΡΔΙΑ. ΜΕ ΤΗΝ ΠΑΡΟΥΣΑ ΜΕΛΕΤΗ ΜΑΣ, ΧΡΗΣΙΜΟΠΟΙΩΝΤΑΣ ΜΗ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΟΥΣ ΕΠΙΜΥΣ ΑΠΟΔΕΙΞΑΜΕ ΠΩΣ ΟΙ Α-ΑΔΡΕΝΕΡΓΙΚΟΙ ΔΙΕΓΕΡΤΕΣ ΧΟΡΗΓΟΥΜΕΝΟΙ ΤΟΠΙΚΑ ΣΤΟΝ ΠΜΔ, ΜΕ ΜΙΚΡΟΕΝΕΣΕΙΣ 'Η ΣΥΝΕΧΗ ΕΓΧΥΣΗ ΠΡΟΚΑΛΟΥΝ ΥΠΕΡΤΑΣΗ ΚΑΙ ΒΡΑΔΥΚΑΡΔΙΑ. ΣΤΗΝ ΣΥΝΕΧΕΙΑ ΕΠΑΝΑΛΑΜΒΑΝΟΝΤΑΣ ΤΑ ΠΕΙΡΑΜΑΤΑ ΜΑΣ ΜΕ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΑ ΖΩΑ ΚΑΤΑΔΕΙΞΑΜΕ ΤΟΝ ΣΥΣΚΟΤΙΣΤΙΚΟ ΡΟΛΟ ΤΗΣ ΑΝΑΙΣΘΗΣΙΑΣ ΚΑΙ ΕΡΜΗΝΕΥΣΑΜΕ ΤΙΣ ΔΙΑΦΟΡΕΣ ΜΑΣ ΜΕ ΤΟΥΣ ΠΡΟΗΓΟΥΜΕΝΟΥΣ ΕΡΕΥΝΗΤΕΣ."]},{"key":"dc:title","label":"Title","values":["ΚΑΡΔΙΑΓΓΕΙΑΚΕΣ ΜΕΤΑΒΟΛΕΣ ΑΠΟ ΤΗΝ ΕΝΑΠΟΘΕΣΗ ΝΟΡΕΠΙΝΕΦΡΙΝΗΣ ΚΑΙ ΚΛΟΝΙΔΙΝΗΣ ΣΤΟΝ ΠΥΡΗΝΑ ΤΗΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ ΤΟΥ ΠΡΟΜΗΚΗ ΜΥΕΛΟΥ ΜΗ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΩΝ ΕΠΙΜΥΩΝ ΚΑΙ Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΓΕΝΙΚΗΣ ΑΝΑΙΣΘΗΣΙΑΣ ΣΤΙΣ ΜΕΤΑΒΟΛΕΣ ΑΥΤΕΣ","CARDIOVASCULAR RESPONSES TO LOCAL APPLICATION OF NOREPINEPHRINE AND CLONIDINE INTO THE NUCLEUS TRACTUS SOLITARIUS AT THE MEDULLA OBLOGATA OF NON-ANESTHETIZED RATS AND THE EFFECT OF GENERAL ANESTHESIA ON THESE RESPONSES"]}]}],"canonical_facts":{"dc:creator":["Vlahakos, Dimitrios","Βλαχάκος, Δημήτριος"],"dc:date":["1988"],"dc:description":["THE NUCLEUS TRACTUS SOLITARIUS (NTS) AT THE LEVEL OF THE MEDULLA OBLOCATA IS THE FIRST AND MOST IMPORTANT CENTER OF THE BARORECEPTOR REFLEX AND ONE OF THE LOCI WHERE THE CATECHOLAMINES REGULATE CENTRALLY THE LEVELS OF THE ARTERIAL BLOOD PRESSURE. PREVIOUS RESEARCH ON ANESTHETIZED ANIMALS CONCLUDED THAT LOCAL APPLICATION OF A-ADRENERGIC AGONISTS INTO THE NTS RESULTS IN HYPOTENSION AND BRADYCARDIA. HOWEVER, OUR STUDIES BASED UPON NON- ANESTHETIZED RATS, SHOWED THAT NOREPINEPHRIN LOCALLY APPLIED INTO THE NTS RESULT IN HYPERTENSION AND BRADYCARDIA. BYREPEATING THE LOCAL APPLICATION OF NOREPINEPHINE AND CLONIDINE TO RATS ANESTHETIZED WITH ETHER, URETHANE OR NEBUTAL, WE SHOWED THAT GENERAL ANESTHESIA MASKEDTHE CARDIOVASCULAR RESPONSES AND THEREFORE WE EXPLAINED OUR DIFFERENCES WITH THE PREVIOUS RESEARCHES.","Ο ΠΥΡΗΝΑΣ ΤΗΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ (ΠΜΔ) ΣΤΟΝ ΠΡΟΜΗΚΗ ΜΥΕΛΟ ΕΙΝΑΙ ΤΟ ΠΡΩΤΟ ΚΑΙ ΣΠΟΥΔΑΙΟΤΕΡΟ ΚΕΝΤΡΟ ΤΟΥ ΚΑΡΔΙΑΓΓΕΙΑΚΟΥ ΑΝΤΑΝΑΚΛΑΣΤΙΚΟΥ ΤΟΞΟΥ ΤΩΝ ΤΑΣΕΟΥΠΟΔΟΧΕΩΝ, ΠΕΡΙΕΧΕΙ ΚΑΤΕΧΟΛΑΜΙΝΕΡΓΙΚΕΣ ΝΕΥΡΙΚΕΣ ΑΠΟΛΗΞΕΙΣ ΚΑΙ Α2 ΑΔΡΕΝΕΡΓΙΚΟΥΣ ΥΠΟΔΟΧΕΙΣ ΚΑΙ ΘΕΩΡΕΙΤΑΙ ΕΝΑΣ ΑΠΟ ΤΟΥΣ ΤΟΠΟΥΣ ΟΠΟΥ ΟΙ ΚΑΤΕΧΟΛΑΜΙΝΕΣ ΑΣΚΟΥΝ ΤΗΝ ΡΥΘΜΙΣΤΙΚΗ ΤΟΥΣ ΔΡΑΣΗ ΣΤΑ ΕΠΙΠΕΔΑ ΤΗΣ ΑΡΤΗΡΙΑΚΗΣ ΠΙΕΣΕΩΣ. Η ΜΕΧΡΙ ΤΩΡΑ ΕΡΕΥΝΑ, ΜΕ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΑ ΠΕΙΡΑΜΑΤΟΖΩΑ ΟΔΗΓΗΣΕ ΣΤΟ ΣΥΜΠΕΡΑΣΜΑ ΠΩΣ ΟΙ Α-ΑΔΡΕΝΕΡΓΙΚΟΙ ΔΙΕΓΕΡΤΕΣ ΧΟΡΗΓΟΥΜΕΝΟΙ ΤΟΠΙΚΑ ΣΤΟΝ ΠΜΔ ΠΡΟΚΑΛΟΥΝ ΥΠΟΤΑΣΗ ΚΑΙ ΒΡΑΔΥΚΑΡΔΙΑ. ΜΕ ΤΗΝ ΠΑΡΟΥΣΑ ΜΕΛΕΤΗ ΜΑΣ, ΧΡΗΣΙΜΟΠΟΙΩΝΤΑΣ ΜΗ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΟΥΣ ΕΠΙΜΥΣ ΑΠΟΔΕΙΞΑΜΕ ΠΩΣ ΟΙ Α-ΑΔΡΕΝΕΡΓΙΚΟΙ ΔΙΕΓΕΡΤΕΣ ΧΟΡΗΓΟΥΜΕΝΟΙ ΤΟΠΙΚΑ ΣΤΟΝ ΠΜΔ, ΜΕ ΜΙΚΡΟΕΝΕΣΕΙΣ 'Η ΣΥΝΕΧΗ ΕΓΧΥΣΗ ΠΡΟΚΑΛΟΥΝ ΥΠΕΡΤΑΣΗ ΚΑΙ ΒΡΑΔΥΚΑΡΔΙΑ. ΣΤΗΝ ΣΥΝΕΧΕΙΑ ΕΠΑΝΑΛΑΜΒΑΝΟΝΤΑΣ ΤΑ ΠΕΙΡΑΜΑΤΑ ΜΑΣ ΜΕ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΑ ΖΩΑ ΚΑΤΑΔΕΙΞΑΜΕ ΤΟΝ ΣΥΣΚΟΤΙΣΤΙΚΟ ΡΟΛΟ ΤΗΣ ΑΝΑΙΣΘΗΣΙΑΣ ΚΑΙ ΕΡΜΗΝΕΥΣΑΜΕ ΤΙΣ ΔΙΑΦΟΡΕΣ ΜΑΣ ΜΕ ΤΟΥΣ ΠΡΟΗΓΟΥΜΕΝΟΥΣ ΕΡΕΥΝΗΤΕΣ."],"dc:identifier":["10.12681/eadd/0722","http://hdl.handle.net/10442/hedi/0722"],"dc:language":["gre"],"dc:publisher":["University of Patras","Πανεπιστήμιο Πατρών"],"dc:subject":["ΑΙΘΕΡΑΣ","ΑΝΤΑΝΑΚΛΑΣΤΙΚΟ ΤΟΞΟ ΤΩΝ ΤΑΣΕΟΥΠΟΔΟΧΕΩΝ","Γενική αναισθησία","Κλονιδίνη","Νορεπινεφρίνη","Ουρεθάνη","ΠΕΝΤΟΒΑΡΒΙΤΑΛΗ","ΠΡΟΜΗΚΗΣ ΜΥΕΛΟΣ","ΠΥΡΗΝΑΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ","BARORECEPTOR REFLEX","Clonidine","ETHER","GENERAL ANESTHESIΑ","MEDULLA OBLOGATA","Norepinephrine","NUCLEUS TRACTUS SOLITARIUS","PENTOBARBITAL","Urethane","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["ΚΑΡΔΙΑΓΓΕΙΑΚΕΣ ΜΕΤΑΒΟΛΕΣ ΑΠΟ ΤΗΝ ΕΝΑΠΟΘΕΣΗ ΝΟΡΕΠΙΝΕΦΡΙΝΗΣ ΚΑΙ ΚΛΟΝΙΔΙΝΗΣ ΣΤΟΝ ΠΥΡΗΝΑ ΤΗΣ ΜΟΝΗΡΟΥΣ ΔΕΣΜΙΔΑΣ ΤΟΥ ΠΡΟΜΗΚΗ ΜΥΕΛΟΥ ΜΗ ΑΝΑΙΣΘΗΤΟΠΟΙΗΜΕΝΩΝ ΕΠΙΜΥΩΝ ΚΑΙ Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΓΕΝΙΚΗΣ ΑΝΑΙΣΘΗΣΙΑΣ ΣΤΙΣ ΜΕΤΑΒΟΛΕΣ ΑΥΤΕΣ","CARDIOVASCULAR RESPONSES TO LOCAL APPLICATION OF NOREPINEPHRINE AND CLONIDINE INTO THE NUCLEUS TRACTUS SOLITARIUS AT THE MEDULLA OBLOGATA OF NON-ANESTHETIZED RATS AND THE EFFECT OF GENERAL ANESTHESIA ON THESE RESPONSES"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:24Z"}