{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0671"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0671","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΕΠΙΔΡΑΣΗ ΤΟΥ ΦΟΡΒΟΛΙΚΟΥ ΕΣΤΕΡΑ ΤΡΑ ΣΕ ΑΝΘΡΩΠΙΝΑ ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ","abstract":"IN THIS STUDY WE HAVE INVESTIGATED THE EFFECT OF THE PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON TWO HUMAN LEUKEMIC CELL LINES: 1) THE MOLT3 CELL LINE, WHICH SHOWS TWO PHENOTYPES, THAT OF LARGE THYMIC BLASTS (ABOUT 50% OFTHE CELLS). 2) THE SDK CELL LINE, WHICH INCLUDES CELLS WITH EITHER THE PHENOTYPE OF MATURE B LYMPHOCYTES (60-70% OF THE CELL POPULATION) OR OF PLASMACYTOID OR PLASMA CELLS (THE REMAINING CELLS. IT HAS BEEN FOUND THAT TPA, AT THE CONCENTRATION OF 16NM, INDUCED, IN BOTH CELL LINES, PHENOTYPIC AND FUNCTIONAL CHANGES,INDICATING DIFFERENTIATION OF THE CELLS TOWARDS MORE MATURE STAGES. (SHORTENED)","abstract_html":"IN THIS STUDY WE HAVE INVESTIGATED THE EFFECT OF THE PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON TWO HUMAN LEUKEMIC CELL LINES: 1) THE MOLT3 CELL LINE, WHICH SHOWS TWO PHENOTYPES, THAT OF LARGE THYMIC BLASTS (ABOUT 50% OFTHE CELLS). 2) THE SDK CELL LINE, WHICH INCLUDES CELLS WITH EITHER THE PHENOTYPE OF MATURE B LYMPHOCYTES (60-70% OF THE CELL POPULATION) OR OF PLASMACYTOID OR PLASMA CELLS (THE REMAINING CELLS. IT HAS BEEN FOUND THAT TPA, AT THE CONCENTRATION OF 16NM, INDUCED, IN BOTH CELL LINES, PHENOTYPIC AND FUNCTIONAL CHANGES,INDICATING DIFFERENTIATION OF THE CELLS TOWARDS MORE MATURE STAGES. (SHORTENED)","abstract_has_math":false,"creators":["Περέζ, Σόνια"],"institution":"Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1988,"date_issued":"1988","date_published":"1988","updated_at":"2026-07-24T02:25:24Z","subjects":["Differentiation","GLUCOCORTICOSTEROID SENSITIVITY (TO)","LEUKEMIC LYMPHOCYTE","MITOGEN STIMULATION","NK LYSIS","Phorbol esters","POLY(A) METABOLIZING ENZYMES","Διαφοροποίηση","ΔΙΕΓΕΡΣΗ ΜΕ ΜΙΤΟΓΟΝΑ","ΕΝΖΥΜΑ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΟΥ ΠΟΛΥ(Α)","ΕΥΑΙΣΘΗΣΙΑ ΣΕ ΓΛΥΚΟΚΟΡΤΙΚΟΣΤΕΡΟΕΙΔΗ","ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ","ΝΚ ΛΥΣΗ","Φορβολικοί εστέρες","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0671"],"render_values":[{"text":"10.12681/eadd/0671","href":"https://doi.org/10.12681/eadd/0671","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0671","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Περέζ, Σόνια"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1988"]},{"key":"dc:publisher","label":"Institution","values":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Differentiation","GLUCOCORTICOSTEROID SENSITIVITY (TO)","LEUKEMIC LYMPHOCYTE","MITOGEN STIMULATION","NK LYSIS","Phorbol esters","POLY(A) METABOLIZING ENZYMES","Διαφοροποίηση","ΔΙΕΓΕΡΣΗ ΜΕ ΜΙΤΟΓΟΝΑ","ΕΝΖΥΜΑ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΟΥ ΠΟΛΥ(Α)","ΕΥΑΙΣΘΗΣΙΑ ΣΕ ΓΛΥΚΟΚΟΡΤΙΚΟΣΤΕΡΟΕΙΔΗ","ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ","ΝΚ ΛΥΣΗ","Φορβολικοί εστέρες","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0671","http://hdl.handle.net/10442/hedi/0671"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THIS STUDY WE HAVE INVESTIGATED THE EFFECT OF THE PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON TWO HUMAN LEUKEMIC CELL LINES: 1) THE MOLT3 CELL LINE, WHICH SHOWS TWO PHENOTYPES, THAT OF LARGE THYMIC BLASTS (ABOUT 50% OFTHE CELLS). 2) THE SDK CELL LINE, WHICH INCLUDES CELLS WITH EITHER THE PHENOTYPE OF MATURE B LYMPHOCYTES (60-70% OF THE CELL POPULATION) OR OF PLASMACYTOID OR PLASMA CELLS (THE REMAINING CELLS. IT HAS BEEN FOUND THAT TPA, AT THE CONCENTRATION OF 16NM, INDUCED, IN BOTH CELL LINES, PHENOTYPIC AND FUNCTIONAL CHANGES,INDICATING DIFFERENTIATION OF THE CELLS TOWARDS MORE MATURE STAGES. (SHORTENED)","ΣΤΗΝ ΕΡΓΑΣΙΑ ΑΥΤΗ ΕΞΕΤΑΣΘΗΚΕ Η ΕΠΙΔΡΑΣΗ 16ΝΜ ΤΡΑ ΣΕ ΔΥΟ ΑΝΘΡΩΠΙΝΕΣ ΛΕΥΧΑΙΜΙΚΕΣ ΚΥΤΤΑΡΙΚΕΣ ΣΕΙΡΕΣ: 1) ΤΗΝ ΣΕΙΡΑ MOLT3, ΚΥΤΤΑΡΑ ΜΕ ΦΑΙΝΟΤΥΠΟ ΜΕΓΑΛΩΝ ΘΥΜΙΚΩΝ ΒΛΑΣΤΩΝ (ΠΕΡΙΠΟΥ 50%) ΚΑΙ ΚΛΑΣΙΚΩΝ ΦΛΟΙΩΔΩΝ ΘΥΜΟΚΥΤΤΑΡΩΝ (ΤΑ ΥΠΟΛΟΙΠΑ). 2) ΤΗΝ ΣΕΙΡΑ SDK, ΚΥΤΤΑΡΑ ΜΕ ΦΑΙΝΟΤΥΠΟ ΩΡΙΜΟΥ Β ΛΕΜΦΟΚΥΤΤΑΡΟΥ (60-70%) ΚΑΙ ΠΛΑΣΜΑΤΟΚΥΤΤΟΕΙΔΟΥΣ Β ΛΕΜΦΟΚΥΤΤΑΡΟΥ 'Η ΠΛΑΣΜΑΤΟΚΥΤΤΑΡΟΥ (ΤΑ ΥΠΟΛΟΙΠΑ). ΒΡΕΘΗΚΕ ΟΤΙ ΤΟ ΤΡΑ, ΣΤΗΝ ΣΥΓΚΕΝΤΡΩΣΗ ΑΥΤΗ, ΕΠΑΓΕΙ, ΚΑΙ ΣΤΙΣ ΔΥΟ ΚΥΤΤΑΡΙΚΕΣ ΣΕΙΡΕΣ, ΦΑΙΝΟΤΥΠΙΚΕΣ ΚΑΙ ΛΕΙΤΟΥΡΓΙΚΕΣ ΑΛΛΑΓΕΣ, ΟΙ ΟΠΟΙΕΣ ΥΠΟΔΕΙΚΝΥΟΥΝ ΔΙΑΦΟΡΟΠΟΙΗΣΗ ΤΩΝ ΚΥΤΤΑΡΩΝ ΣΕ ΠΙΟ ΩΡΙΜΑ ΣΤΑΔΙΑ. (ΠΕΡΙΚΟΠΗ)"]},{"key":"dc:title","label":"Title","values":["ΕΠΙΔΡΑΣΗ ΤΟΥ ΦΟΡΒΟΛΙΚΟΥ ΕΣΤΕΡΑ ΤΡΑ ΣΕ ΑΝΘΡΩΠΙΝΑ ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ","EFFECT OF TPA A PHORBOL ESTER, ON HUMAN LEUKEMIC LYMPHOCYTES"]}]}],"canonical_facts":{"dc:creator":["Περέζ, Σόνια"],"dc:date":["1988"],"dc:description":["IN THIS STUDY WE HAVE INVESTIGATED THE EFFECT OF THE PHORBOL ESTER 12-O-TETRADECANOYLPHORBOL-13-ACETATE (TPA) ON TWO HUMAN LEUKEMIC CELL LINES: 1) THE MOLT3 CELL LINE, WHICH SHOWS TWO PHENOTYPES, THAT OF LARGE THYMIC BLASTS (ABOUT 50% OFTHE CELLS). 2) THE SDK CELL LINE, WHICH INCLUDES CELLS WITH EITHER THE PHENOTYPE OF MATURE B LYMPHOCYTES (60-70% OF THE CELL POPULATION) OR OF PLASMACYTOID OR PLASMA CELLS (THE REMAINING CELLS. IT HAS BEEN FOUND THAT TPA, AT THE CONCENTRATION OF 16NM, INDUCED, IN BOTH CELL LINES, PHENOTYPIC AND FUNCTIONAL CHANGES,INDICATING DIFFERENTIATION OF THE CELLS TOWARDS MORE MATURE STAGES. (SHORTENED)","ΣΤΗΝ ΕΡΓΑΣΙΑ ΑΥΤΗ ΕΞΕΤΑΣΘΗΚΕ Η ΕΠΙΔΡΑΣΗ 16ΝΜ ΤΡΑ ΣΕ ΔΥΟ ΑΝΘΡΩΠΙΝΕΣ ΛΕΥΧΑΙΜΙΚΕΣ ΚΥΤΤΑΡΙΚΕΣ ΣΕΙΡΕΣ: 1) ΤΗΝ ΣΕΙΡΑ MOLT3, ΚΥΤΤΑΡΑ ΜΕ ΦΑΙΝΟΤΥΠΟ ΜΕΓΑΛΩΝ ΘΥΜΙΚΩΝ ΒΛΑΣΤΩΝ (ΠΕΡΙΠΟΥ 50%) ΚΑΙ ΚΛΑΣΙΚΩΝ ΦΛΟΙΩΔΩΝ ΘΥΜΟΚΥΤΤΑΡΩΝ (ΤΑ ΥΠΟΛΟΙΠΑ). 2) ΤΗΝ ΣΕΙΡΑ SDK, ΚΥΤΤΑΡΑ ΜΕ ΦΑΙΝΟΤΥΠΟ ΩΡΙΜΟΥ Β ΛΕΜΦΟΚΥΤΤΑΡΟΥ (60-70%) ΚΑΙ ΠΛΑΣΜΑΤΟΚΥΤΤΟΕΙΔΟΥΣ Β ΛΕΜΦΟΚΥΤΤΑΡΟΥ 'Η ΠΛΑΣΜΑΤΟΚΥΤΤΑΡΟΥ (ΤΑ ΥΠΟΛΟΙΠΑ). ΒΡΕΘΗΚΕ ΟΤΙ ΤΟ ΤΡΑ, ΣΤΗΝ ΣΥΓΚΕΝΤΡΩΣΗ ΑΥΤΗ, ΕΠΑΓΕΙ, ΚΑΙ ΣΤΙΣ ΔΥΟ ΚΥΤΤΑΡΙΚΕΣ ΣΕΙΡΕΣ, ΦΑΙΝΟΤΥΠΙΚΕΣ ΚΑΙ ΛΕΙΤΟΥΡΓΙΚΕΣ ΑΛΛΑΓΕΣ, ΟΙ ΟΠΟΙΕΣ ΥΠΟΔΕΙΚΝΥΟΥΝ ΔΙΑΦΟΡΟΠΟΙΗΣΗ ΤΩΝ ΚΥΤΤΑΡΩΝ ΣΕ ΠΙΟ ΩΡΙΜΑ ΣΤΑΔΙΑ. (ΠΕΡΙΚΟΠΗ)"],"dc:identifier":["10.12681/eadd/0671","http://hdl.handle.net/10442/hedi/0671"],"dc:language":["gre"],"dc:publisher":["Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)","National and Kapodistrian University of Athens"],"dc:subject":["Differentiation","GLUCOCORTICOSTEROID SENSITIVITY (TO)","LEUKEMIC LYMPHOCYTE","MITOGEN STIMULATION","NK LYSIS","Phorbol esters","POLY(A) METABOLIZING ENZYMES","Διαφοροποίηση","ΔΙΕΓΕΡΣΗ ΜΕ ΜΙΤΟΓΟΝΑ","ΕΝΖΥΜΑ ΜΕΤΑΒΟΛΙΣΜΟΥ ΤΟΥ ΠΟΛΥ(Α)","ΕΥΑΙΣΘΗΣΙΑ ΣΕ ΓΛΥΚΟΚΟΡΤΙΚΟΣΤΕΡΟΕΙΔΗ","ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ","ΝΚ ΛΥΣΗ","Φορβολικοί εστέρες","Natural Sciences","Biological Sciences","Φυσικές Επιστήμες","Βιολογία"],"dc:title":["ΕΠΙΔΡΑΣΗ ΤΟΥ ΦΟΡΒΟΛΙΚΟΥ ΕΣΤΕΡΑ ΤΡΑ ΣΕ ΑΝΘΡΩΠΙΝΑ ΛΕΥΧΑΙΜΙΚΑ ΛΕΜΦΟΚΥΤΤΑΡΑ","EFFECT OF TPA A PHORBOL ESTER, ON HUMAN LEUKEMIC LYMPHOCYTES"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:24Z"}