{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0664"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0664","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΑΝΟΣΟΑΠΟΚΡΙΣΕΙΣ ΦΥΣΙΟΛΟΓΙΚΩΝ ΚΑΙ ΑΡΘΡΙΤΙΚΩΝ ΑΡΟΥΡΑΙΩΝ ΣΕ ΔΙΑΦΟΡΑ ΑΝΤΙΓΟΝΑ ΚΑΙ ΜΙΤΟΓΟΝΑ","abstract":"IN OUR TRY TO STUDY THE MECHANISM BY WHICH EXPERIMENTAL ARTHRITIS (AID: ADJUVANT INDUCED DISEASE) INDUCED TO RATS WE STUDIED SOME IMMUNOLOGICAL PARAMETERS. INTHE BEGINNING WE FOUND THAT BACTERIAL LIPOPOLYSACCHARIDE FROM E.COLI IS A POLYCLONAL ACTIVATOR (MITOGEN) OF NORMAL RAT B-LYMPHOCYTES IN VIVO AND IN VITRO. INVITRO LPS ACTIVATES B-LYMPHOCYTES, ONLY AFTER ACTIVATION OF T-LYMPHOCYTES OR MACROPHAGES OR BOTH, WHICH IN TURN SECRETS FACTOR(S) WHICH HELP B-LYMPHOCYTES TORESPOND. THE MITOGENIC RESPONSES OF NORMAL OR AID RAT SPLENOCYTES TO LPS IS SIMILAR. IN CONTRAST THE MITOGENIC RESPONSE OF AID RAT SPLENOCYTES TO CON-A, 18-24 DAYS AFTER FREUD'S COMPLETE ADJUVANT (FCA) INJECTION (FOR AID INDUCTION) IS REDUCED COMPARED TO THE RESPONSE OF NORMAL RAT SPLENOCYTES. (SHORTENED)","abstract_html":"IN OUR TRY TO STUDY THE MECHANISM BY WHICH EXPERIMENTAL ARTHRITIS (AID: ADJUVANT INDUCED DISEASE) INDUCED TO RATS WE STUDIED SOME IMMUNOLOGICAL PARAMETERS. INTHE BEGINNING WE FOUND THAT BACTERIAL LIPOPOLYSACCHARIDE FROM E.COLI IS A POLYCLONAL ACTIVATOR (MITOGEN) OF NORMAL RAT B-LYMPHOCYTES IN VIVO AND IN VITRO. INVITRO LPS ACTIVATES B-LYMPHOCYTES, ONLY AFTER ACTIVATION OF T-LYMPHOCYTES OR MACROPHAGES OR BOTH, WHICH IN TURN SECRETS FACTOR(S) WHICH HELP B-LYMPHOCYTES TORESPOND. THE MITOGENIC RESPONSES OF NORMAL OR AID RAT SPLENOCYTES TO LPS IS SIMILAR. IN CONTRAST THE MITOGENIC RESPONSE OF AID RAT SPLENOCYTES TO CON-A, 18-24 DAYS AFTER FREUD'S COMPLETE ADJUVANT (FCA) INJECTION (FOR AID INDUCTION) IS REDUCED COMPARED TO THE RESPONSE OF NORMAL RAT SPLENOCYTES. (SHORTENED)","abstract_has_math":false,"creators":["Yiangou, Minas","Γιάγκου, Μηνάς"],"institution":"Aristotle University Of Thessaloniki (AUTH)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:24Z","subjects":["ΑΝΟΣΟΑΠΟΚΡΙΣΕΙΣ","ΚΥΤΤΑΡΑ ΠΟΥ ΣΧΗΜΑΤΙΖΟΥΝ ΑΝΟΣΟΠΛΑΚΕΣ","ΜΙΤΟΓΟΝΙΚΕΣ ΑΠΟΚΡΙΣΕΙΣ","ΠΑΡΑΓΩΓΗ ΛΕΜΦΟΚΙΝΩΝ","Αρθρίτιδα, Πειραματική","ADJUVANT INDUCE DISEASE AID","Immune response","LYMPHOKINE PRODUCTION","MITOGENIC RESPONSES","PLAQUE FORMING CELLS","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0664"],"render_values":[{"text":"10.12681/eadd/0664","href":"https://doi.org/10.12681/eadd/0664","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0664","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Yiangou, Minas","Γιάγκου, Μηνάς"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["Aristotle University Of Thessaloniki (AUTH)","Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΑΝΟΣΟΑΠΟΚΡΙΣΕΙΣ","ΚΥΤΤΑΡΑ ΠΟΥ ΣΧΗΜΑΤΙΖΟΥΝ ΑΝΟΣΟΠΛΑΚΕΣ","ΜΙΤΟΓΟΝΙΚΕΣ ΑΠΟΚΡΙΣΕΙΣ","ΠΑΡΑΓΩΓΗ ΛΕΜΦΟΚΙΝΩΝ","Αρθρίτιδα, Πειραματική","ADJUVANT INDUCE DISEASE AID","Immune response","LYMPHOKINE PRODUCTION","MITOGENIC RESPONSES","PLAQUE FORMING CELLS","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0664","http://hdl.handle.net/10442/hedi/0664"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN OUR TRY TO STUDY THE MECHANISM BY WHICH EXPERIMENTAL ARTHRITIS (AID: ADJUVANT INDUCED DISEASE) INDUCED TO RATS WE STUDIED SOME IMMUNOLOGICAL PARAMETERS. INTHE BEGINNING WE FOUND THAT BACTERIAL LIPOPOLYSACCHARIDE FROM E.COLI IS A POLYCLONAL ACTIVATOR (MITOGEN) OF NORMAL RAT B-LYMPHOCYTES IN VIVO AND IN VITRO. INVITRO LPS ACTIVATES B-LYMPHOCYTES, ONLY AFTER ACTIVATION OF T-LYMPHOCYTES OR MACROPHAGES OR BOTH, WHICH IN TURN SECRETS FACTOR(S) WHICH HELP B-LYMPHOCYTES TORESPOND. THE MITOGENIC RESPONSES OF NORMAL OR AID RAT SPLENOCYTES TO LPS IS SIMILAR. IN CONTRAST THE MITOGENIC RESPONSE OF AID RAT SPLENOCYTES TO CON-A, 18-24 DAYS AFTER FREUD'S COMPLETE ADJUVANT (FCA) INJECTION (FOR AID INDUCTION) IS REDUCED COMPARED TO THE RESPONSE OF NORMAL RAT SPLENOCYTES. (SHORTENED)","ΜΕΣΑ ΣΤΑ ΠΛΑΙΣΙΑ ΤΗΣ ΜΕΛΕΤΗΣ ΤΟΥ ΜΗΧΑΝΙΣΜΟΥ ΕΠΑΓΩΓΗΣ ΤΗΣ ΠΕΙΡΑΜΑΤΙΚΗΣ ΑΡΘΡΙΤΙΔΑΣ ΣΤΟΥΣ ΑΡΟΥΡΑΙΟΥΣ ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ ΔΙΑΦΟΡΕΣ ΑΝΟΣΟΒΙΟΛΟΓΙΚΕΣ ΠΑΡΑΜΕΤΡΟΙ. ΑΡΧΙΚΑ,ΒΡΕΘΗΚΕ ΟΤΙ Ο ΒΑΚΤΗΡΙΑΚΟΣ ΛΙΠΟΠΟΛΥΣΑΚΧΑΡΙΤΗΣ (LPS) ΠΟΥ ΠΡΟΕΡΧΕΤΑΙ ΑΠΟ ΤΟ Ε.COLI ΕΙΝΑΙ ΠΟΛΥΚΛΩΝΙΚΟΣ ΕΝΕΡΓΟΠΟΙΗΤΗΣ (ΜΙΤΟΓΟΝΟ) ΤΩΝ Β-ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΑΡΟΥΡΑΙΩΝ IN VIVO, ΑΛΛΑ ΚΑΙ IN VITRO ΥΠΟ ΤΗΝ ΠΡΟΥΠΟΘΕΣΗ ΟΤΙ ΘΑ ΕΝΕΡΓΟΠΟΙΗΘΟΥΝ ΣΤΗΝ ΚΑΛΛΙΕΡΓΕΙΑ ΤΑ Τ- ΛΕΜΦΟΚΥΤΤΑΡΑ 'Η ΤΑ ΜΑΚΡΟΦΑΓΑ 'Η ΚΑΙ ΤΑ ΔΥΟ, ΓΙΑ ΝΑ ΕΚΚΡΙΝΟΥΝ ΚΑΠΟΙΟΝ 'Η ΚΑΠΟΙΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΘΑ ΒΟΗΘΗΣΟΥΝ ΤΑ Β-ΛΕΜΦΟΚΥΤΤΑΡΑ ΤΟΥ ΣΠΛΗΝΑ ΝΑ ΕΝΕΡΓΟΠΟΙΗΘΟΥΝ ΑΠΟ ΤΟΝ LPS. ΟΙ ΜΙΤΟΓΟΝΙΚΕΣ ΑΠΟΚΡΙΣΕΙΣ ΤΩΝ Β-ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΤΟΥ ΣΠΛΗΝΑ ΤΩΝ ΑΡΘΡΙΤΙΚΩΝ ΑΡΟΥΡΑΙΩΝ ΣΤΟ LPS ΔΕΝ ΦΑΙΝΕΤΑΙ ΝΑ ΔΙΑΦΕΡΟΥΝ ΑΠΟ ΤΗΝ ΑΝΤΙΣΤΟΙΧΗ ΑΠΟΚΡΙΣΗ ΤΩΝ ΣΠΛΗΝΟΚΥΤΤΑΡΩΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΑΡΟΥΡΑΙΩΝ. (ΠΕΡΙΚΟΠΗ)"]},{"key":"dc:title","label":"Title","values":["ΑΝΟΣΟΑΠΟΚΡΙΣΕΙΣ ΦΥΣΙΟΛΟΓΙΚΩΝ ΚΑΙ ΑΡΘΡΙΤΙΚΩΝ ΑΡΟΥΡΑΙΩΝ ΣΕ ΔΙΑΦΟΡΑ ΑΝΤΙΓΟΝΑ ΚΑΙ ΜΙΤΟΓΟΝΑ","IMMUNE RESPONSES OF NORMAL AND ARTHRITIC RATS TO VARIOUS ANTIGENS AND MITOGENS"]}]}],"canonical_facts":{"dc:creator":["Yiangou, Minas","Γιάγκου, Μηνάς"],"dc:date":["1987"],"dc:description":["IN OUR TRY TO STUDY THE MECHANISM BY WHICH EXPERIMENTAL ARTHRITIS (AID: ADJUVANT INDUCED DISEASE) INDUCED TO RATS WE STUDIED SOME IMMUNOLOGICAL PARAMETERS. INTHE BEGINNING WE FOUND THAT BACTERIAL LIPOPOLYSACCHARIDE FROM E.COLI IS A POLYCLONAL ACTIVATOR (MITOGEN) OF NORMAL RAT B-LYMPHOCYTES IN VIVO AND IN VITRO. INVITRO LPS ACTIVATES B-LYMPHOCYTES, ONLY AFTER ACTIVATION OF T-LYMPHOCYTES OR MACROPHAGES OR BOTH, WHICH IN TURN SECRETS FACTOR(S) WHICH HELP B-LYMPHOCYTES TORESPOND. THE MITOGENIC RESPONSES OF NORMAL OR AID RAT SPLENOCYTES TO LPS IS SIMILAR. IN CONTRAST THE MITOGENIC RESPONSE OF AID RAT SPLENOCYTES TO CON-A, 18-24 DAYS AFTER FREUD'S COMPLETE ADJUVANT (FCA) INJECTION (FOR AID INDUCTION) IS REDUCED COMPARED TO THE RESPONSE OF NORMAL RAT SPLENOCYTES. (SHORTENED)","ΜΕΣΑ ΣΤΑ ΠΛΑΙΣΙΑ ΤΗΣ ΜΕΛΕΤΗΣ ΤΟΥ ΜΗΧΑΝΙΣΜΟΥ ΕΠΑΓΩΓΗΣ ΤΗΣ ΠΕΙΡΑΜΑΤΙΚΗΣ ΑΡΘΡΙΤΙΔΑΣ ΣΤΟΥΣ ΑΡΟΥΡΑΙΟΥΣ ΠΡΟΣΔΙΟΡΙΣΤΗΚΑΝ ΔΙΑΦΟΡΕΣ ΑΝΟΣΟΒΙΟΛΟΓΙΚΕΣ ΠΑΡΑΜΕΤΡΟΙ. ΑΡΧΙΚΑ,ΒΡΕΘΗΚΕ ΟΤΙ Ο ΒΑΚΤΗΡΙΑΚΟΣ ΛΙΠΟΠΟΛΥΣΑΚΧΑΡΙΤΗΣ (LPS) ΠΟΥ ΠΡΟΕΡΧΕΤΑΙ ΑΠΟ ΤΟ Ε.COLI ΕΙΝΑΙ ΠΟΛΥΚΛΩΝΙΚΟΣ ΕΝΕΡΓΟΠΟΙΗΤΗΣ (ΜΙΤΟΓΟΝΟ) ΤΩΝ Β-ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΑΡΟΥΡΑΙΩΝ IN VIVO, ΑΛΛΑ ΚΑΙ IN VITRO ΥΠΟ ΤΗΝ ΠΡΟΥΠΟΘΕΣΗ ΟΤΙ ΘΑ ΕΝΕΡΓΟΠΟΙΗΘΟΥΝ ΣΤΗΝ ΚΑΛΛΙΕΡΓΕΙΑ ΤΑ Τ- ΛΕΜΦΟΚΥΤΤΑΡΑ 'Η ΤΑ ΜΑΚΡΟΦΑΓΑ 'Η ΚΑΙ ΤΑ ΔΥΟ, ΓΙΑ ΝΑ ΕΚΚΡΙΝΟΥΝ ΚΑΠΟΙΟΝ 'Η ΚΑΠΟΙΟΥΣ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΘΑ ΒΟΗΘΗΣΟΥΝ ΤΑ Β-ΛΕΜΦΟΚΥΤΤΑΡΑ ΤΟΥ ΣΠΛΗΝΑ ΝΑ ΕΝΕΡΓΟΠΟΙΗΘΟΥΝ ΑΠΟ ΤΟΝ LPS. ΟΙ ΜΙΤΟΓΟΝΙΚΕΣ ΑΠΟΚΡΙΣΕΙΣ ΤΩΝ Β-ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΤΟΥ ΣΠΛΗΝΑ ΤΩΝ ΑΡΘΡΙΤΙΚΩΝ ΑΡΟΥΡΑΙΩΝ ΣΤΟ LPS ΔΕΝ ΦΑΙΝΕΤΑΙ ΝΑ ΔΙΑΦΕΡΟΥΝ ΑΠΟ ΤΗΝ ΑΝΤΙΣΤΟΙΧΗ ΑΠΟΚΡΙΣΗ ΤΩΝ ΣΠΛΗΝΟΚΥΤΤΑΡΩΝ ΤΩΝ ΦΥΣΙΟΛΟΓΙΚΩΝ ΑΡΟΥΡΑΙΩΝ. (ΠΕΡΙΚΟΠΗ)"],"dc:identifier":["10.12681/eadd/0664","http://hdl.handle.net/10442/hedi/0664"],"dc:language":["gre"],"dc:publisher":["Aristotle University Of Thessaloniki (AUTH)","Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)"],"dc:subject":["ΑΝΟΣΟΑΠΟΚΡΙΣΕΙΣ","ΚΥΤΤΑΡΑ ΠΟΥ ΣΧΗΜΑΤΙΖΟΥΝ ΑΝΟΣΟΠΛΑΚΕΣ","ΜΙΤΟΓΟΝΙΚΕΣ ΑΠΟΚΡΙΣΕΙΣ","ΠΑΡΑΓΩΓΗ ΛΕΜΦΟΚΙΝΩΝ","Αρθρίτιδα, Πειραματική","ADJUVANT INDUCE DISEASE AID","Immune response","LYMPHOKINE PRODUCTION","MITOGENIC RESPONSES","PLAQUE FORMING CELLS","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"dc:title":["ΑΝΟΣΟΑΠΟΚΡΙΣΕΙΣ ΦΥΣΙΟΛΟΓΙΚΩΝ ΚΑΙ ΑΡΘΡΙΤΙΚΩΝ ΑΡΟΥΡΑΙΩΝ ΣΕ ΔΙΑΦΟΡΑ ΑΝΤΙΓΟΝΑ ΚΑΙ ΜΙΤΟΓΟΝΑ","IMMUNE RESPONSES OF NORMAL AND ARTHRITIC RATS TO VARIOUS ANTIGENS AND MITOGENS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:24Z"}