{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0653"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0653","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΙΣΤΟΠΑΘΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΑΛΛΟΙΩΣΕΩΝ ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΤΟΥ ΗΠΑΤΟΣ ΚΑΙ ΤΩΝ ΝΕΦΡΩΝ ΑΠΟ ΤΟΞΙΚΕΣ ΔΟΣΕΙΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΑ ΚΟΥΝΕΛΙΑ","abstract":"IN THIS STUDY 32 WHITE NEW ZEALAND RABBITS WERE EXAMINED FOR TOXIC EFFECTS OF PHENYTOIN, IN THE BRAIN, LIVER AND KIDNEYS IN RELATION TO THE CONCENTRATION OF PHENYTOIN IN THEIR BLOOD. ALL MEASUREMENTS WERE MADE USING R.I.A. METHOD. THE RABBITS WERE DIVIDED INTO THREE GROUPS, A,B AND C. PHENYTOIN WAS GIVEN INTRAMUSCULARY IN GROUPS A AND B IN DOSES OF 100 MG AND 200 PER KG BODY WEIGHT RESPECTIVELY AND 250 MG PER KG BODY WEIGHT IN GROUP C INTRAPERITONEALLY DAILY FOR A PERIOD OF 20 DAYS. IN ORDER TO RECORD CLINICAL SYMPTOMS, OBSERVATIONS OF THE RABBITSWERE MADE EVERY DAY FOR SEVERAL HOURS AND MEASUREMENTS OF THE CONCENTRATION OFPHENYTOIN IN THE BLOOD WERE MADE, IN SAMPLES TAKEN EVERY WEEK. (SHORTENED)","abstract_html":"IN THIS STUDY 32 WHITE NEW ZEALAND RABBITS WERE EXAMINED FOR TOXIC EFFECTS OF PHENYTOIN, IN THE BRAIN, LIVER AND KIDNEYS IN RELATION TO THE CONCENTRATION OF PHENYTOIN IN THEIR BLOOD. ALL MEASUREMENTS WERE MADE USING R.I.A. METHOD. THE RABBITS WERE DIVIDED INTO THREE GROUPS, A,B AND C. PHENYTOIN WAS GIVEN INTRAMUSCULARY IN GROUPS A AND B IN DOSES OF 100 MG AND 200 PER KG BODY WEIGHT RESPECTIVELY AND 250 MG PER KG BODY WEIGHT IN GROUP C INTRAPERITONEALLY DAILY FOR A PERIOD OF 20 DAYS. IN ORDER TO RECORD CLINICAL SYMPTOMS, OBSERVATIONS OF THE RABBITSWERE MADE EVERY DAY FOR SEVERAL HOURS AND MEASUREMENTS OF THE CONCENTRATION OFPHENYTOIN IN THE BLOOD WERE MADE, IN SAMPLES TAKEN EVERY WEEK. (SHORTENED)","abstract_has_math":false,"creators":["Πέγιος, Γεώργιος"],"institution":"Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:24Z","subjects":["PATHOLOGY OF THE BRAIN","PATHOLOGY OF THE KIDNEYS","PATHOLOGY OF THE LIVER","Phenytoin","Rabbits","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΕΓΚΕΦΑΛΟΥ","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΗΠΑΤΟΣ","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΝΕΦΡΩΝ","Κουνέλια","Φαινυτοΐνη","Γεωπονικές Επιστήμες και Κτηνιατρική","Agricultural and Veterinary Sciences","Κτηνιατρική","Veterinary Science"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0653"],"render_values":[{"text":"10.12681/eadd/0653","href":"https://doi.org/10.12681/eadd/0653","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0653","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Πέγιος, Γεώργιος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)","Aristotle University Of Thessaloniki (AUTH)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["PATHOLOGY OF THE BRAIN","PATHOLOGY OF THE KIDNEYS","PATHOLOGY OF THE LIVER","Phenytoin","Rabbits","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΕΓΚΕΦΑΛΟΥ","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΗΠΑΤΟΣ","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΝΕΦΡΩΝ","Κουνέλια","Φαινυτοΐνη","Γεωπονικές Επιστήμες και Κτηνιατρική","Agricultural and Veterinary Sciences","Κτηνιατρική","Veterinary Science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0653","http://hdl.handle.net/10442/hedi/0653"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THIS STUDY 32 WHITE NEW ZEALAND RABBITS WERE EXAMINED FOR TOXIC EFFECTS OF PHENYTOIN, IN THE BRAIN, LIVER AND KIDNEYS IN RELATION TO THE CONCENTRATION OF PHENYTOIN IN THEIR BLOOD. ALL MEASUREMENTS WERE MADE USING R.I.A. METHOD. THE RABBITS WERE DIVIDED INTO THREE GROUPS, A,B AND C. PHENYTOIN WAS GIVEN INTRAMUSCULARY IN GROUPS A AND B IN DOSES OF 100 MG AND 200 PER KG BODY WEIGHT RESPECTIVELY AND 250 MG PER KG BODY WEIGHT IN GROUP C INTRAPERITONEALLY DAILY FOR A PERIOD OF 20 DAYS. IN ORDER TO RECORD CLINICAL SYMPTOMS, OBSERVATIONS OF THE RABBITSWERE MADE EVERY DAY FOR SEVERAL HOURS AND MEASUREMENTS OF THE CONCENTRATION OFPHENYTOIN IN THE BLOOD WERE MADE, IN SAMPLES TAKEN EVERY WEEK. (SHORTENED)","ΣΤΗ ΜΕΛΕΤΗ ΑΥΤΗ ΕΡΕΥΝΗΘΗΚΕ ΣΕ ΚΟΥΝΕΛΙΑ Η ΤΟΞΙΚΗ ΔΡΑΣΗ ΤΗΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΟΝ ΕΓΚΕΦΑΛΟ, ΣΤΟ ΗΠΑΡ ΚΑΙ ΣΤΟΥΣ ΝΕΦΡΟΥΣ, ΣΕ ΣΥΝΑΡΤΗΣΗ ΜΕ ΤΑ ΕΠΙΠΕΔΑ ΣΥΓΚΕΝΤΡΩΣΗΣ ΤΗΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΟΝ ΟΡΟ ΤΟΥ ΑΙΜΑΤΟΣ, ΤΑ ΟΠΟΙΑ ΜΕΤΡΗΘΗΚΑΝ ΜΕ ΤΗ RIA ΜΕΘΟΔΟ. ΓΙΑ ΤΗΝ ΠΡΑΓΜΑΤΟΠΟΙΗΣΗ ΑΥΤΗΣ ΤΗΣ ΕΡΕΥΝΑΣ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ 32 ΛΕΥΚΑ ΚΟΥΝΕΛΙΑ ΝΕΑΣ ΖΗΛΑΝΔΙΑΣ. ΤΑ ΠΕΙΡΑΜΑΤΟΖΩΑ ΧΩΡΙΣΤΗΚΑΝ ΣΕ ΤΡΕΙΣ ΟΜΑΔΕΣ, Α,Β ΚΑΙ Γ. Η ΦΑΙΝΥΤΟΙΝΗ ΧΟΡΗΓΗΘΗΚΕ ΣΤΗΝ Α ΚΑΙ Β ΟΜΑΔΑ ΕΝΔΟΜΥΙΚΩΣ ΣΤΗ ΔΟΣΗ ΤΩΝ 100 ΚΑΙ 200 MG/KG Σ.Β. ΤΗΝ ΗΜΕΡΑ ΚΑΙ ΣΤΗ Γ ΟΜΑΔΑ ΕΝΔΟΠΕΡΙΤΟΝΑΙΚΩΣ ΣΤΗ ΔΟΣΗ ΤΩΝ 250 MG/KG Σ.Β. ΤΗΝ ΗΜΕΡΑ, ΓΙΑ ΧΡΟΝΙΚΟ ΔΙΑΣΤΗΜΑ 20 ΗΜΕΡΩΝ. ΓΙΑ ΤΗΝ ΚΑΤΑΓΡΑΦΗ ΤΩΝ ΚΛΙΝΙΚΩΝ ΣΥΜΠΤΩΜΑΤΩΝ, Η ΜΕΤΡΗΣΗ ΤΩΝ ΕΠΙΠΕΔΩΝ ΣΥΓΚΕΝΤΡΩΣΗΣ ΤΗΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΟΝ ΟΡΟ ΤΟΥ ΑΙΜΑΤΟΣ ΓΙΝΟΤΑΝ ΚΑΘΕ ΕΒΔΟΜΑΔΑ ΚΑΙ Η ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΤΩΝ ΠΕΙΡΑΜΑΤΟΖΩΩΝ ΓΙΝΟΤΑΝ ΚΑΘΕ ΗΜΕΡΑ ΓΙΑ ΠΟΛΛΕΣ ΩΡΕΣ. (ΠΕΡΙΚΟΠΗ)"]},{"key":"dc:title","label":"Title","values":["ΙΣΤΟΠΑΘΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΑΛΛΟΙΩΣΕΩΝ ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΤΟΥ ΗΠΑΤΟΣ ΚΑΙ ΤΩΝ ΝΕΦΡΩΝ ΑΠΟ ΤΟΞΙΚΕΣ ΔΟΣΕΙΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΑ ΚΟΥΝΕΛΙΑ","HISTOPATHOLOGICAL LESIONS IN THE BRAIN, LIVER AND KIDNEYS CAUSED BY TOXICAL DOSES OF PHENYTOIN IN RABBITS"]}]}],"canonical_facts":{"dc:creator":["Πέγιος, Γεώργιος"],"dc:date":["1987"],"dc:description":["IN THIS STUDY 32 WHITE NEW ZEALAND RABBITS WERE EXAMINED FOR TOXIC EFFECTS OF PHENYTOIN, IN THE BRAIN, LIVER AND KIDNEYS IN RELATION TO THE CONCENTRATION OF PHENYTOIN IN THEIR BLOOD. ALL MEASUREMENTS WERE MADE USING R.I.A. METHOD. THE RABBITS WERE DIVIDED INTO THREE GROUPS, A,B AND C. PHENYTOIN WAS GIVEN INTRAMUSCULARY IN GROUPS A AND B IN DOSES OF 100 MG AND 200 PER KG BODY WEIGHT RESPECTIVELY AND 250 MG PER KG BODY WEIGHT IN GROUP C INTRAPERITONEALLY DAILY FOR A PERIOD OF 20 DAYS. IN ORDER TO RECORD CLINICAL SYMPTOMS, OBSERVATIONS OF THE RABBITSWERE MADE EVERY DAY FOR SEVERAL HOURS AND MEASUREMENTS OF THE CONCENTRATION OFPHENYTOIN IN THE BLOOD WERE MADE, IN SAMPLES TAKEN EVERY WEEK. (SHORTENED)","ΣΤΗ ΜΕΛΕΤΗ ΑΥΤΗ ΕΡΕΥΝΗΘΗΚΕ ΣΕ ΚΟΥΝΕΛΙΑ Η ΤΟΞΙΚΗ ΔΡΑΣΗ ΤΗΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΟΝ ΕΓΚΕΦΑΛΟ, ΣΤΟ ΗΠΑΡ ΚΑΙ ΣΤΟΥΣ ΝΕΦΡΟΥΣ, ΣΕ ΣΥΝΑΡΤΗΣΗ ΜΕ ΤΑ ΕΠΙΠΕΔΑ ΣΥΓΚΕΝΤΡΩΣΗΣ ΤΗΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΟΝ ΟΡΟ ΤΟΥ ΑΙΜΑΤΟΣ, ΤΑ ΟΠΟΙΑ ΜΕΤΡΗΘΗΚΑΝ ΜΕ ΤΗ RIA ΜΕΘΟΔΟ. ΓΙΑ ΤΗΝ ΠΡΑΓΜΑΤΟΠΟΙΗΣΗ ΑΥΤΗΣ ΤΗΣ ΕΡΕΥΝΑΣ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ 32 ΛΕΥΚΑ ΚΟΥΝΕΛΙΑ ΝΕΑΣ ΖΗΛΑΝΔΙΑΣ. ΤΑ ΠΕΙΡΑΜΑΤΟΖΩΑ ΧΩΡΙΣΤΗΚΑΝ ΣΕ ΤΡΕΙΣ ΟΜΑΔΕΣ, Α,Β ΚΑΙ Γ. Η ΦΑΙΝΥΤΟΙΝΗ ΧΟΡΗΓΗΘΗΚΕ ΣΤΗΝ Α ΚΑΙ Β ΟΜΑΔΑ ΕΝΔΟΜΥΙΚΩΣ ΣΤΗ ΔΟΣΗ ΤΩΝ 100 ΚΑΙ 200 MG/KG Σ.Β. ΤΗΝ ΗΜΕΡΑ ΚΑΙ ΣΤΗ Γ ΟΜΑΔΑ ΕΝΔΟΠΕΡΙΤΟΝΑΙΚΩΣ ΣΤΗ ΔΟΣΗ ΤΩΝ 250 MG/KG Σ.Β. ΤΗΝ ΗΜΕΡΑ, ΓΙΑ ΧΡΟΝΙΚΟ ΔΙΑΣΤΗΜΑ 20 ΗΜΕΡΩΝ. ΓΙΑ ΤΗΝ ΚΑΤΑΓΡΑΦΗ ΤΩΝ ΚΛΙΝΙΚΩΝ ΣΥΜΠΤΩΜΑΤΩΝ, Η ΜΕΤΡΗΣΗ ΤΩΝ ΕΠΙΠΕΔΩΝ ΣΥΓΚΕΝΤΡΩΣΗΣ ΤΗΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΟΝ ΟΡΟ ΤΟΥ ΑΙΜΑΤΟΣ ΓΙΝΟΤΑΝ ΚΑΘΕ ΕΒΔΟΜΑΔΑ ΚΑΙ Η ΠΑΡΑΚΟΛΟΥΘΗΣΗ ΤΩΝ ΠΕΙΡΑΜΑΤΟΖΩΩΝ ΓΙΝΟΤΑΝ ΚΑΘΕ ΗΜΕΡΑ ΓΙΑ ΠΟΛΛΕΣ ΩΡΕΣ. (ΠΕΡΙΚΟΠΗ)"],"dc:identifier":["10.12681/eadd/0653","http://hdl.handle.net/10442/hedi/0653"],"dc:language":["gre"],"dc:publisher":["Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)","Aristotle University Of Thessaloniki (AUTH)"],"dc:subject":["PATHOLOGY OF THE BRAIN","PATHOLOGY OF THE KIDNEYS","PATHOLOGY OF THE LIVER","Phenytoin","Rabbits","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΕΓΚΕΦΑΛΟΥ","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΗΠΑΤΟΣ","ΙΣΤΟΠΑΘΟΛΟΓΙΑ ΝΕΦΡΩΝ","Κουνέλια","Φαινυτοΐνη","Γεωπονικές Επιστήμες και Κτηνιατρική","Agricultural and Veterinary Sciences","Κτηνιατρική","Veterinary Science"],"dc:title":["ΙΣΤΟΠΑΘΟΛΟΓΙΚΗ ΜΕΛΕΤΗ ΤΩΝ ΑΛΛΟΙΩΣΕΩΝ ΤΟΥ ΕΓΚΕΦΑΛΟΥ ΤΟΥ ΗΠΑΤΟΣ ΚΑΙ ΤΩΝ ΝΕΦΡΩΝ ΑΠΟ ΤΟΞΙΚΕΣ ΔΟΣΕΙΣ ΦΑΙΝΥΤΟΙΝΗΣ ΣΤΑ ΚΟΥΝΕΛΙΑ","HISTOPATHOLOGICAL LESIONS IN THE BRAIN, LIVER AND KIDNEYS CAUSED BY TOXICAL DOSES OF PHENYTOIN IN RABBITS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:24Z"}