{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0474"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0474","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΜΕΛΕΤΗ ΜΙΑΣ ΕΙΔΙΚΗΣ ΡΙΒΟΝΟΥΚΛΕΑΣΗΣ ΚΑΙ ΕΝΟΣ ΑΝΑΣΤΟΛΕΑ ΤΗΣ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΑΠΟ ΠΡΟΝΥΜΦΕΣ 6 ΗΜΕΡΩΝ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA","abstract":"THIS THESIS IS PART OF THE SCIENTIFIC PROGRAM OF OUR LABORATORY WHICH STUDIES THE TRANSLATIONAL CONTROL DURING THE DEVELOPMENT OF THE INSECT CERATITIS CAPITATA. IN THE FIRST PART OF THIS WORK THE METHOD OF PURIFICATION OF A NEW RIBONUCLEASE IS DEVELOPED. VARIOUS PROPERTIES ARE STUDIED, TOGETHER WITH HER ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS. AMONG THE CONCLUSIONS ARE THE FOLLOWING: A) THE RIBONUCLEASE THAT IS ISOLATED FROM THE LARVAE OF CERATITIS CAPITATA IS A THERMOSABILE MOLECULE WITH MOLECULAR WEIGHT OF 25000 DALTONS. B) THIS ENZYME DEGRADES SPECIFICALLY POLY(U) AND POLY(C) WHEREAS IT HAS NO EFFECT ON POLY(A), POLY(G) AND POLY(U,C). IT HYDROLYSES THE 18S AND 28S RIBOSOMAL RNA TO VARIOUS SPECIES OF RNAS WHICH ARE NOT HYDROLYSED ANY FURTHER. IN THE SECOND PART OF THIS WORK THE METHOD OF PARTIAL PURIFICATION OF A FACTOR WHICH INHIBITS THE ELONGATION OF NASCENT POLYPEPTIDE CHAINS OF POLYRIBOSOMES IS DEVELOPED ANDHS PROPERTIES TOGETHER WITH ITS ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS ARE STUDIED.","abstract_html":"THIS THESIS IS PART OF THE SCIENTIFIC PROGRAM OF OUR LABORATORY WHICH STUDIES THE TRANSLATIONAL CONTROL DURING THE DEVELOPMENT OF THE INSECT CERATITIS CAPITATA. IN THE FIRST PART OF THIS WORK THE METHOD OF PURIFICATION OF A NEW RIBONUCLEASE IS DEVELOPED. VARIOUS PROPERTIES ARE STUDIED, TOGETHER WITH HER ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS. AMONG THE CONCLUSIONS ARE THE FOLLOWING: A) THE RIBONUCLEASE THAT IS ISOLATED FROM THE LARVAE OF CERATITIS CAPITATA IS A THERMOSABILE MOLECULE WITH MOLECULAR WEIGHT OF 25000 DALTONS. B) THIS ENZYME DEGRADES SPECIFICALLY POLY(U) AND POLY(C) WHEREAS IT HAS NO EFFECT ON POLY(A), POLY(G) AND POLY(U,C). IT HYDROLYSES THE 18S AND 28S RIBOSOMAL RNA TO VARIOUS SPECIES OF RNAS WHICH ARE NOT HYDROLYSED ANY FURTHER. IN THE SECOND PART OF THIS WORK THE METHOD OF PARTIAL PURIFICATION OF A FACTOR WHICH INHIBITS THE ELONGATION OF NASCENT POLYPEPTIDE CHAINS OF POLYRIBOSOMES IS DEVELOPED ANDHS PROPERTIES TOGETHER WITH ITS ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS ARE STUDIED.","abstract_has_math":false,"creators":["Sideris, Diamandis","Σίδερης, Διαμάντης"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1987,"date_issued":"1987","date_published":"1987","updated_at":"2026-07-24T02:25:17Z","subjects":["ΑΝΑΣΤΟΛΕΑΣ ΤΗΣ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ","ΕΙΔΙΚΗ ΡΙΒΟΝΟΥΚΛΕΑΣΗ","Ceratitis capitata","INHIBITOR OF PROTEIN SYNTHESIS","SPECIFIC RIBONUCLEASE","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0474"],"render_values":[{"text":"10.12681/eadd/0474","href":"https://doi.org/10.12681/eadd/0474","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0474","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Sideris, Diamandis","Σίδερης, Διαμάντης"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1987"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΑΝΑΣΤΟΛΕΑΣ ΤΗΣ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ","ΕΙΔΙΚΗ ΡΙΒΟΝΟΥΚΛΕΑΣΗ","Ceratitis capitata","INHIBITOR OF PROTEIN SYNTHESIS","SPECIFIC RIBONUCLEASE","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0474","http://hdl.handle.net/10442/hedi/0474"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THIS THESIS IS PART OF THE SCIENTIFIC PROGRAM OF OUR LABORATORY WHICH STUDIES THE TRANSLATIONAL CONTROL DURING THE DEVELOPMENT OF THE INSECT CERATITIS CAPITATA. IN THE FIRST PART OF THIS WORK THE METHOD OF PURIFICATION OF A NEW RIBONUCLEASE IS DEVELOPED. VARIOUS PROPERTIES ARE STUDIED, TOGETHER WITH HER ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS. AMONG THE CONCLUSIONS ARE THE FOLLOWING: A) THE RIBONUCLEASE THAT IS ISOLATED FROM THE LARVAE OF CERATITIS CAPITATA IS A THERMOSABILE MOLECULE WITH MOLECULAR WEIGHT OF 25000 DALTONS. B) THIS ENZYME DEGRADES SPECIFICALLY POLY(U) AND POLY(C) WHEREAS IT HAS NO EFFECT ON POLY(A), POLY(G) AND POLY(U,C). IT HYDROLYSES THE 18S AND 28S RIBOSOMAL RNA TO VARIOUS SPECIES OF RNAS WHICH ARE NOT HYDROLYSED ANY FURTHER. IN THE SECOND PART OF THIS WORK THE METHOD OF PARTIAL PURIFICATION OF A FACTOR WHICH INHIBITS THE ELONGATION OF NASCENT POLYPEPTIDE CHAINS OF POLYRIBOSOMES IS DEVELOPED ANDHS PROPERTIES TOGETHER WITH ITS ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS ARE STUDIED.","Η ΕΡΓΑΣΙΑ ΑΥΤΗ ΕΝΤΑΣΣΕΤΑΙ ΣΤΟ ΓΕΝΙΚΟΤΕΡΟ ΕΡΕΥΝΗΤΙΚΟ ΠΡΟΓΡΑΜΜΑ ΤΟΥ ΕΡΓΑΣΤΗΡΙΟΥ ΜΑΣ, ΤΟ ΟΠΟΙΟ ΑΦΟΡΑ ΤΗ ΜΕΛΕΤΗ ΤΟΥ ΜΕΤΑΦΡΑΣΤΙΚΟΥ ΕΛΕΓΧΟΥ ΚΑΤΑ ΤΗΝ ΑΝΑΠΤΥΞΗ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA. ΣΤΟ ΠΡΩΤΟ ΜΕΡΟΣ ΤΗΣ ΕΡΓΑΣΙΑΣ ΑΥΤΗΣ ΑΝΑΠΤΥΣΣΕΤΑΙ Η ΜΕΘΟΔΟΛΟΓΙΑ ΚΑΘΑΡΙΣΜΟΥ ΜΙΑΣ ΝΕΑΣ ΡΙΒΟΝΟΥΚΛΕΑΣΗΣ ΚΑΙ ΜΕΛΕΤΩΝΤΑΙ ΔΙΑΦΟΡΕΣ ΙΔΙΟΤΗΤΕΣ ΤΗΣ, ΚΑΘΩΣ ΚΑΙ Η ΔΡΑΣΗ ΤΗΣ ΣΕ IN VITRO ΣΥΣΤΗΜΑΤΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ. ΑΠΟ ΤΗ ΜΕΛΕΤΗ ΤΩΝ ΙΔΙΟΤΗΤΩΝ ΑΥΤΩΝ ΠΡΟΚΥΠΤΕΙ ΟΤΙ: Α) Η ΡΙΒΟΝΟΥΚΛΕΑΣΗ ΠΟΥ ΑΠΟΜΟΝΩΝΕΤΑΙ ΑΠΟ ΤΙΣ ΠΡΟΝΥΜΦΕΣ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA, ΕΙΝΑΙ ΕΝΑ ΘΕΡΜΟΕΥΑΙΣΘΗΤΟ ΜΟΡΙΟ ΜΕ ΜΟΡΙΑΚΟ ΒΑΡΟΣ 25000 DALTONS. Β) ΤΟ ΕΝΖΥΜΟ ΑΥΤΟ, ΑΠΟΙΚΟΔΟΜΕΙ ΕΙΔΙΚΑ ΤΟ POLY(O) ΚΑΙ ΤΟ POLY(C), ΕΝΩ ΔΕΝ ΕΠΙΔΡΑ ΕΠΙ ΤΟΥ POLY(A), ΤΟΥ POLY(G) ΚΑΙ ΤΟΥ POLY(U,C) ΚΑΙ ΥΔΡΟΛΥΕΙ ΤΟ 18S ΚΑΙ 28S ΡΙΒΟΣΩΜΙΚΟ RNA, ΣΧΗΜΑΤΙΖΟΝΤΑΣ ΔΙΑΦΟΡΑ ΚΟΜΜΑΤΙΑ RNA, ΤΑ ΟΠΟΙΑ ΔΕΝ ΑΠΟΙΚΟΔΟΜΟΥΝΤΑΙ ΠΕΡΙΣΣΟΤΕΡΟ. ΣΤΟ ΔΕΥΤΕΡΟ ΜΕΡΟΣ ΤΗΣ ΕΡΓΑΣΙΑΣ ΑΝΑΠΤΥΣΣΕΤΑΙ Η ΜΕΘΟΔΟΛΟΓΙΑ ΜΕΡΙΚΟΥ ΚΑΘΑΡΙΣΜΟΥ ΕΝΟΣ ΠΑΡΑΓΟΝΤΑ, Ο ΟΠΟΙΟΣ ΠΑΡΕΜΠΟΔΙΖΕΙ ΤΗΝ ΕΠΙΜΥΚΥΝΣΗ ΤΩΝ ΑΡΤΙΓΕΝΩΝ ΠΟΛΥΠΕΠΤΙΔΙΚΩΝ ΑΛΥΣΙΔΩΝ ΤΩΝ ΠΟΛΥΣΩΜΑΤΩΝΚΑΙ ΜΕΛΕΤΩΝΤΑΙ ΟΙ ΙΔΙΟΤΗΤΕΣ ΤΟΥ ΚΑΙ Η ΔΡΑΣΗ ΤΟΥ ΣΕ IN VITRO ΣΥΣΤΗΜΑΤΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ."]},{"key":"dc:title","label":"Title","values":["ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΜΕΛΕΤΗ ΜΙΑΣ ΕΙΔΙΚΗΣ ΡΙΒΟΝΟΥΚΛΕΑΣΗΣ ΚΑΙ ΕΝΟΣ ΑΝΑΣΤΟΛΕΑ ΤΗΣ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΑΠΟ ΠΡΟΝΥΜΦΕΣ 6 ΗΜΕΡΩΝ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA","PURIFICATION AND STUDY OF A SPECIFIC RIBONUCLEASE AND OF AN INHIBITOR OF PROTEIN SYNTHESIS FROM 6-DAY OLD LARVAE OF THE INSECT CERATITIS CAPITATA"]}]}],"canonical_facts":{"dc:creator":["Sideris, Diamandis","Σίδερης, Διαμάντης"],"dc:date":["1987"],"dc:description":["THIS THESIS IS PART OF THE SCIENTIFIC PROGRAM OF OUR LABORATORY WHICH STUDIES THE TRANSLATIONAL CONTROL DURING THE DEVELOPMENT OF THE INSECT CERATITIS CAPITATA. IN THE FIRST PART OF THIS WORK THE METHOD OF PURIFICATION OF A NEW RIBONUCLEASE IS DEVELOPED. VARIOUS PROPERTIES ARE STUDIED, TOGETHER WITH HER ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS. AMONG THE CONCLUSIONS ARE THE FOLLOWING: A) THE RIBONUCLEASE THAT IS ISOLATED FROM THE LARVAE OF CERATITIS CAPITATA IS A THERMOSABILE MOLECULE WITH MOLECULAR WEIGHT OF 25000 DALTONS. B) THIS ENZYME DEGRADES SPECIFICALLY POLY(U) AND POLY(C) WHEREAS IT HAS NO EFFECT ON POLY(A), POLY(G) AND POLY(U,C). IT HYDROLYSES THE 18S AND 28S RIBOSOMAL RNA TO VARIOUS SPECIES OF RNAS WHICH ARE NOT HYDROLYSED ANY FURTHER. IN THE SECOND PART OF THIS WORK THE METHOD OF PARTIAL PURIFICATION OF A FACTOR WHICH INHIBITS THE ELONGATION OF NASCENT POLYPEPTIDE CHAINS OF POLYRIBOSOMES IS DEVELOPED ANDHS PROPERTIES TOGETHER WITH ITS ACTION IN IN VITRO SYSTEMS OF PROTEIN SYNTHESIS ARE STUDIED.","Η ΕΡΓΑΣΙΑ ΑΥΤΗ ΕΝΤΑΣΣΕΤΑΙ ΣΤΟ ΓΕΝΙΚΟΤΕΡΟ ΕΡΕΥΝΗΤΙΚΟ ΠΡΟΓΡΑΜΜΑ ΤΟΥ ΕΡΓΑΣΤΗΡΙΟΥ ΜΑΣ, ΤΟ ΟΠΟΙΟ ΑΦΟΡΑ ΤΗ ΜΕΛΕΤΗ ΤΟΥ ΜΕΤΑΦΡΑΣΤΙΚΟΥ ΕΛΕΓΧΟΥ ΚΑΤΑ ΤΗΝ ΑΝΑΠΤΥΞΗ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA. ΣΤΟ ΠΡΩΤΟ ΜΕΡΟΣ ΤΗΣ ΕΡΓΑΣΙΑΣ ΑΥΤΗΣ ΑΝΑΠΤΥΣΣΕΤΑΙ Η ΜΕΘΟΔΟΛΟΓΙΑ ΚΑΘΑΡΙΣΜΟΥ ΜΙΑΣ ΝΕΑΣ ΡΙΒΟΝΟΥΚΛΕΑΣΗΣ ΚΑΙ ΜΕΛΕΤΩΝΤΑΙ ΔΙΑΦΟΡΕΣ ΙΔΙΟΤΗΤΕΣ ΤΗΣ, ΚΑΘΩΣ ΚΑΙ Η ΔΡΑΣΗ ΤΗΣ ΣΕ IN VITRO ΣΥΣΤΗΜΑΤΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ. ΑΠΟ ΤΗ ΜΕΛΕΤΗ ΤΩΝ ΙΔΙΟΤΗΤΩΝ ΑΥΤΩΝ ΠΡΟΚΥΠΤΕΙ ΟΤΙ: Α) Η ΡΙΒΟΝΟΥΚΛΕΑΣΗ ΠΟΥ ΑΠΟΜΟΝΩΝΕΤΑΙ ΑΠΟ ΤΙΣ ΠΡΟΝΥΜΦΕΣ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA, ΕΙΝΑΙ ΕΝΑ ΘΕΡΜΟΕΥΑΙΣΘΗΤΟ ΜΟΡΙΟ ΜΕ ΜΟΡΙΑΚΟ ΒΑΡΟΣ 25000 DALTONS. Β) ΤΟ ΕΝΖΥΜΟ ΑΥΤΟ, ΑΠΟΙΚΟΔΟΜΕΙ ΕΙΔΙΚΑ ΤΟ POLY(O) ΚΑΙ ΤΟ POLY(C), ΕΝΩ ΔΕΝ ΕΠΙΔΡΑ ΕΠΙ ΤΟΥ POLY(A), ΤΟΥ POLY(G) ΚΑΙ ΤΟΥ POLY(U,C) ΚΑΙ ΥΔΡΟΛΥΕΙ ΤΟ 18S ΚΑΙ 28S ΡΙΒΟΣΩΜΙΚΟ RNA, ΣΧΗΜΑΤΙΖΟΝΤΑΣ ΔΙΑΦΟΡΑ ΚΟΜΜΑΤΙΑ RNA, ΤΑ ΟΠΟΙΑ ΔΕΝ ΑΠΟΙΚΟΔΟΜΟΥΝΤΑΙ ΠΕΡΙΣΣΟΤΕΡΟ. ΣΤΟ ΔΕΥΤΕΡΟ ΜΕΡΟΣ ΤΗΣ ΕΡΓΑΣΙΑΣ ΑΝΑΠΤΥΣΣΕΤΑΙ Η ΜΕΘΟΔΟΛΟΓΙΑ ΜΕΡΙΚΟΥ ΚΑΘΑΡΙΣΜΟΥ ΕΝΟΣ ΠΑΡΑΓΟΝΤΑ, Ο ΟΠΟΙΟΣ ΠΑΡΕΜΠΟΔΙΖΕΙ ΤΗΝ ΕΠΙΜΥΚΥΝΣΗ ΤΩΝ ΑΡΤΙΓΕΝΩΝ ΠΟΛΥΠΕΠΤΙΔΙΚΩΝ ΑΛΥΣΙΔΩΝ ΤΩΝ ΠΟΛΥΣΩΜΑΤΩΝΚΑΙ ΜΕΛΕΤΩΝΤΑΙ ΟΙ ΙΔΙΟΤΗΤΕΣ ΤΟΥ ΚΑΙ Η ΔΡΑΣΗ ΤΟΥ ΣΕ IN VITRO ΣΥΣΤΗΜΑΤΑ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ."],"dc:identifier":["10.12681/eadd/0474","http://hdl.handle.net/10442/hedi/0474"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["ΑΝΑΣΤΟΛΕΑΣ ΤΗΣ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ","ΕΙΔΙΚΗ ΡΙΒΟΝΟΥΚΛΕΑΣΗ","Ceratitis capitata","INHIBITOR OF PROTEIN SYNTHESIS","SPECIFIC RIBONUCLEASE","Φυσικές Επιστήμες","Βιολογία","Natural Sciences","Biological Sciences"],"dc:title":["ΚΑΘΑΡΙΣΜΟΣ ΚΑΙ ΜΕΛΕΤΗ ΜΙΑΣ ΕΙΔΙΚΗΣ ΡΙΒΟΝΟΥΚΛΕΑΣΗΣ ΚΑΙ ΕΝΟΣ ΑΝΑΣΤΟΛΕΑ ΤΗΣ ΠΡΩΤΕΙΝΟΣΥΝΘΕΣΗΣ ΑΠΟ ΠΡΟΝΥΜΦΕΣ 6 ΗΜΕΡΩΝ ΤΟΥ ΕΝΤΟΜΟΥ CERATITIS CAPITATA","PURIFICATION AND STUDY OF A SPECIFIC RIBONUCLEASE AND OF AN INHIBITOR OF PROTEIN SYNTHESIS FROM 6-DAY OLD LARVAE OF THE INSECT CERATITIS CAPITATA"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:17Z"}