ΣΥΜΒΟΛΗ ΣΤΗΝ ΕΡΜΗΝΕΙΑ ΤΗΣ ΝΕΥΡΟΓΕΝΟΥΣ ΡΥΘΜΙΣΗΣ ΤΗΣ ΕΓΚΕΦΑΛΙΚΗΣ ΚΥΚΛΟΦΟΡΙΑΣ
TO TEST THE HYPOTHESIZED ROLE OF GAMMA-AMINOBUTYRIC ACID (GABA) ON THE CEREBRAL CIRCULATION, WE USED A PRESSURE MICRO-INJECTION SYSTEM TO SIMULTANEOUSLY ADMINISTER VARIOUS CONCENTRATIONS OF GABA AND MEASURE THE TISSUE PO22 USING AN ADJACENT PO2 MICROELECTRODE. GABA INJECTED DIRECTLY INTO THE MONGOLIAN GERBIL (MERIONES UNGUICULATUS) HIPPOCAMPUS PRODUCED AN IMMEDIATE, REVERSIBLE INCREASE IN LOCAL TISSUE PO2. CONTROL INJECTIONS OF PHOSPHATE BUFFER (PH=7.4) HAD NO SIGNIFICANT EFFECT ON TISSUE PO2. THE INDUCED INCREASE IN TISSUE PO2 OCCURED WITHIN SECONDS AFTER MICRO-INJECTION OF GABA. THE DURATION OF THE EFFECT WAS DEPENDENT UPON THE DOSE OF GABA WHICH WAS ADMINISTERED. THESE RESULTS SHOW A MODULATION OF TISSUE PO2 BY GABA, AND THEY AGREE WITH THE PROPOSED ROLE OF GABA AS A VASODILATOR IN THE REGULATION OF CEREBRAL MICROCIRCULATION.
P02 ΗΛΕΚΤΡΟΔΙΟ-ΠΙΠΕΤΤΑ ΣΥΣΤΗΜΑ, γ - αμινοβουτυρικό οξύ ( GABA), Ιππόκαμπος, ΙΣΤΙΚΗ ΤΑΣΗ ΟΞΥΓΟΝΟΥ{ΙΣΤ. P02}, Πολαρογραφία, GABA, Hippocampus, P02 ELECTRODE-PIPETTE SYSTEM, Polarography, TISSUE OXYGEN TENSION {TISSUE P02}, Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine
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