ΧΗΜΙΚΗ ΑΝΟΣΙΑ ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΕΝΕΡΓΟ ΗΠΑΤΙΤΙΔΑ ΣΕ ΣΧΕΣΗ ΜΕ ΤΗΝ ΠΑΡΟΥΣΙΑ ΤΟΥ HBSAG

IMMUNOLOGICAL MECHANISMS HAVE BEEN CONCERNED TO PLAY AN IMPORTANT ROLE IN THE DEVELOPMENT OF CHRONIC ACTIVE HEPATITIS (CAH) ALTHOUGH IT IS NOT EASY TO DEFINE THEIR REAL CONTRIBUTION IN THE PATHOGENESIS OF THE DISEASE. THE HUMORAL IMMUNE RESPONSE OF PATIENTS, WITH BIOPSY PROVED, CAH WAS STUDIED, BOTH IN THE HBSAG POSITIVE (40 PATIENTS) AND IN THE HBSAG NEGATIVE (24 PATIENTS) GROUP. SERUM IMMUNOGLOBULINS, VIRAL ANTIBODIES TO RUBELLA, MEASLES AND CYTOMEGALOVIRUS (CMV) AND NON-ORGAN SPECIFIC AUTOANTIBODIES - ANTINUCLEAR (ANA), SMOOTH MUSCLE ANTIBODIES(SMA), AND ANTIMITOCHONDRIAL ANTIBODIES (AMA) - WERE STUDIED. THE IMMUNOGLOBULINS WERE DETERMINED BY SINGLE RADIAL IMMUNODIFFUSION. THE VIRAL ANTIBODIES WEREDETECTED BY THE METHOD OF HEMAGGLUTINATION-INHIBITION AND COMPLEMENT FIXATIONAND THE AUTOANTIBODIES BY INDIRECT IMMUNOFLUORESCENCE. HIGHER LEVELS OF IMMUNOGLOBULINS, SPECIALLY IGG AND IGH, WERE FOUND IN THE HBSAG NEGATIVE GROUP OF PATIENTS. INCREASED FREQUENCY OF ANTIBODIES TO RUBELLA WAS OBSERVED IN ALL PATIENTS OF BOTH GROUPS BUT THERE WAS NO DIFFERENCE BETWEEN THEM. HIGHER LEVELS OF ANTIBODIES TO MEASLES WERE FOUND ONLY IN THE HBSAG NEGATIVE GROUP AND THIS DIFFERENCE WAS STATISTICALLY SIGNIFICANT IN COMPARISON TO THE HBSAG POSITIVE GROUP. THERE WAS NO SIGNIFICANT DIFFERENCE CONCERNING THE ANTIBODIES TO CMV IN THE PATIENTS OF BOTH GROUPS. INCREASED FREQUENCY OF SMA WAS FOUND IN ALL PATIENTS OF BOTH GROUPS WHILE ANA AND AMA WERE DETECTED ONLY IN THE HBSAG NEGATIVE GROUP. THE INCREASED HUMORAL IMMUNE RESPONSE CONCERNING ANTIBODIES TO MEASLES AND NON-ORGAN SPECIFIC AUTOANTIBODIES, WHICH CHARACTERIZES THE HBSAG NEGATIVE GROUP OF PATIENTS COULD BE ATTRIBUTED TO A GENERAL HYPERACTIVITY OF THE IMMUNE SYSTEM TO THESE ANTIGENS.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1985

Author dc:creator

• Κωτσοβόλου-Σώτου, Δανάη

• Αυτοαντισώματα
• Χυμική ανοσία
• ΧΡΟΝΙΑ ΕΝΕΡΓΟΣ ΗΠΑΤΙΤΙΣ
• Autoantibodies
• Chronic active hepatitis
• HUMORAL IMMUNE RESPONSE
• VIRAL ANTIBODIES
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0407

OAI identifier oai:identifier

oai:10442/0407