{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0371"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0371","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΠΕΙΡΑΜΑΤΙΚΗ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑΣ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΑ ΦΑΡΜΑΚΑ","abstract":"IN THE PRESENT ORIGINAL EXPERIMENTAL WORK AN ATTEMPT IS MADE TO STUDY METHOTREXATE-INDUCED HEPATOTOXICITY. SIXTY SIX MALE ALBINO RATS WERE USED. OUR RESULTS ARE THE FOLLOWING: 1. METHOTREXATE- INDUCED HEPATOTOXICITY IS ENHANCED BY CONCOMITANT ADMINISTRATION OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID ADMINISTRATION CAN PREVENT THE HEPATOTOXICITY CAUSED: A. BY THE COMBINATION OF \"METHOTREXATE AND PHENYLBUTAZONE, B. BY THE COMBINATION OF \"METHOTREXATE AND PHENOBARBITAL\".","abstract_html":"IN THE PRESENT ORIGINAL EXPERIMENTAL WORK AN ATTEMPT IS MADE TO STUDY METHOTREXATE-INDUCED HEPATOTOXICITY. SIXTY SIX MALE ALBINO RATS WERE USED. OUR RESULTS ARE THE FOLLOWING: 1. METHOTREXATE- INDUCED HEPATOTOXICITY IS ENHANCED BY CONCOMITANT ADMINISTRATION OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID ADMINISTRATION CAN PREVENT THE HEPATOTOXICITY CAUSED: A. BY THE COMBINATION OF "METHOTREXATE AND PHENYLBUTAZONE, B. BY THE COMBINATION OF "METHOTREXATE AND PHENOBARBITAL".","abstract_has_math":false,"creators":["Φαρφαρέλος, Χρήστος"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1986,"date_issued":"1986","date_published":"1986","updated_at":"2026-07-24T02:25:14Z","subjects":["ΗΠΑΤΟΤΟΧΙΚΟΤΗΤΑ","Μεθοτρεξάτη","ΠΡΟΒΕΝΕΣΙΔΗ","Φαινοβαρβιτάλη","Φαινυλβουταζόνη","Hepatotoxicity","Methotrexate","Phenobarbital","Phenylbutazone","Probenecid","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0371"],"render_values":[{"text":"10.12681/eadd/0371","href":"https://doi.org/10.12681/eadd/0371","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0371","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Φαρφαρέλος, Χρήστος"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1986"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["ΗΠΑΤΟΤΟΧΙΚΟΤΗΤΑ","Μεθοτρεξάτη","ΠΡΟΒΕΝΕΣΙΔΗ","Φαινοβαρβιτάλη","Φαινυλβουταζόνη","Hepatotoxicity","Methotrexate","Phenobarbital","Phenylbutazone","Probenecid","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0371","http://hdl.handle.net/10442/hedi/0371"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THE PRESENT ORIGINAL EXPERIMENTAL WORK AN ATTEMPT IS MADE TO STUDY METHOTREXATE-INDUCED HEPATOTOXICITY. SIXTY SIX MALE ALBINO RATS WERE USED. OUR RESULTS ARE THE FOLLOWING: 1. METHOTREXATE- INDUCED HEPATOTOXICITY IS ENHANCED BY CONCOMITANT ADMINISTRATION OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID ADMINISTRATION CAN PREVENT THE HEPATOTOXICITY CAUSED: A. BY THE COMBINATION OF \"METHOTREXATE AND PHENYLBUTAZONE, B. BY THE COMBINATION OF \"METHOTREXATE AND PHENOBARBITAL\".","ΣΤΗΝ ΠΑΡΟΥΣΑ ΠΡΩΤΟΤΥΠΗ ΠΕΙΡΑΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ΓΙΝΕΤΑΙ ΠΡΟΣΠΑΘΕΙΑ ΝΑ ΜΕΛΕΤΗΘΕΙ Η ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ. ΓΙΑ ΤΟΝ ΣΚΟΠΟ ΑΥΤΟ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΣΥΝΟΛΙΚΑ 66ΑΡΣΕΝΙΚΟΙ ΛΕΥΚΟΙ ΕΠΙΜΥΣ. ΤΑ ΣΥΜΠΕΡΑΣΜΑΤΑ ΜΑΣ ΕΙΝΑΙ ΤΑ ΑΚΟΛΟΥΘΑ: 1. Η ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΑΥΞΑΝΕΙ ΜΕ ΤΑΥΤΟΧΡΟΝΗ ΧΟΡΗΓΗΣΗ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ 'Η ΦΑΙΝΟΒΑΡΒΙΤΑΛΗΣ. 2. Η ΧΟΡΗΓΗΣΗ ΠΡΟΒΕΝΕΣΙΔΗΣ ΜΠΟΡΕΙ ΝΑ ΠΡΟΛΑΒΕΙ ΤΗΝ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑ ΠΟΥ ΠΡΟΚΑΛΕΙ: Α. Ο ΣΥΝΔΥΑΣΜΟΣ \"ΜΕΘΟΤΡΕΞΑΤΗΣ ΚΑΙ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ\". Β. Ο ΣΥΝΔΥΑΣΜΟΣ \"ΜΕΘΟΤΡΕΞΑΤΗΣ ΚΑΙ ΦΑΙΝΟΒΑΡΒΙΤΑΛΗΣ\"."]},{"key":"dc:title","label":"Title","values":["ΠΕΙΡΑΜΑΤΙΚΗ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑΣ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΑ ΦΑΡΜΑΚΑ","EXPERIMENTAL INVESTIGATION OF METHOTREXATE INDUCED HEPATOTOXICITY BY CONCOMITANT ADMINISTRATION OF OTHER DRUGS"]}]}],"canonical_facts":{"dc:creator":["Φαρφαρέλος, Χρήστος"],"dc:date":["1986"],"dc:description":["IN THE PRESENT ORIGINAL EXPERIMENTAL WORK AN ATTEMPT IS MADE TO STUDY METHOTREXATE-INDUCED HEPATOTOXICITY. SIXTY SIX MALE ALBINO RATS WERE USED. OUR RESULTS ARE THE FOLLOWING: 1. METHOTREXATE- INDUCED HEPATOTOXICITY IS ENHANCED BY CONCOMITANT ADMINISTRATION OF PHENYLBUTAZONE OR PHENOBARBITAL, 2. PROBENECID ADMINISTRATION CAN PREVENT THE HEPATOTOXICITY CAUSED: A. BY THE COMBINATION OF \"METHOTREXATE AND PHENYLBUTAZONE, B. BY THE COMBINATION OF \"METHOTREXATE AND PHENOBARBITAL\".","ΣΤΗΝ ΠΑΡΟΥΣΑ ΠΡΩΤΟΤΥΠΗ ΠΕΙΡΑΜΑΤΙΚΗ ΕΡΓΑΣΙΑ ΓΙΝΕΤΑΙ ΠΡΟΣΠΑΘΕΙΑ ΝΑ ΜΕΛΕΤΗΘΕΙ Η ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ. ΓΙΑ ΤΟΝ ΣΚΟΠΟ ΑΥΤΟ ΧΡΗΣΙΜΟΠΟΙΗΘΗΚΑΝ ΣΥΝΟΛΙΚΑ 66ΑΡΣΕΝΙΚΟΙ ΛΕΥΚΟΙ ΕΠΙΜΥΣ. ΤΑ ΣΥΜΠΕΡΑΣΜΑΤΑ ΜΑΣ ΕΙΝΑΙ ΤΑ ΑΚΟΛΟΥΘΑ: 1. Η ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΑΥΞΑΝΕΙ ΜΕ ΤΑΥΤΟΧΡΟΝΗ ΧΟΡΗΓΗΣΗ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ 'Η ΦΑΙΝΟΒΑΡΒΙΤΑΛΗΣ. 2. Η ΧΟΡΗΓΗΣΗ ΠΡΟΒΕΝΕΣΙΔΗΣ ΜΠΟΡΕΙ ΝΑ ΠΡΟΛΑΒΕΙ ΤΗΝ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑ ΠΟΥ ΠΡΟΚΑΛΕΙ: Α. Ο ΣΥΝΔΥΑΣΜΟΣ \"ΜΕΘΟΤΡΕΞΑΤΗΣ ΚΑΙ ΦΑΙΝΥΛΒΟΥΤΑΖΟΝΗΣ\". Β. Ο ΣΥΝΔΥΑΣΜΟΣ \"ΜΕΘΟΤΡΕΞΑΤΗΣ ΚΑΙ ΦΑΙΝΟΒΑΡΒΙΤΑΛΗΣ\"."],"dc:identifier":["10.12681/eadd/0371","http://hdl.handle.net/10442/hedi/0371"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["ΗΠΑΤΟΤΟΧΙΚΟΤΗΤΑ","Μεθοτρεξάτη","ΠΡΟΒΕΝΕΣΙΔΗ","Φαινοβαρβιτάλη","Φαινυλβουταζόνη","Hepatotoxicity","Methotrexate","Phenobarbital","Phenylbutazone","Probenecid","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"dc:title":["ΠΕΙΡΑΜΑΤΙΚΗ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΗΠΑΤΟΤΟΞΙΚΟΤΗΤΑΣ ΤΗΣ ΜΕΘΟΤΡΕΞΑΤΗΣ ΣΕ ΣΥΝΔΥΑΣΜΟ ΜΕ ΑΛΛΑ ΦΑΡΜΑΚΑ","EXPERIMENTAL INVESTIGATION OF METHOTREXATE INDUCED HEPATOTOXICITY BY CONCOMITANT ADMINISTRATION OF OTHER DRUGS"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:14Z"}