ΜΕΛΕΤΗ ΣΥΜΜΕΤΟΧΗΣ ΤΩΝ ΝΤΟΠΑΜΙΝΕΡΓΙΚΩΝ ΝΕΥΡΩΝΩΝ ΣΤΗΝ ΑΡΝΗΤΙΚΗ ΠΑΛΙΝΔΡΟΜΗ ΡΥΘΜΙΣΗ ΤΩΝ ΓΟΝΑΔΟΤΡΟΦΙΝΩΝ ΜΕ ΟΙΣΤΡΟΓΟΝΑ

THE NEGATIVE FEEDBACK CONTROL OF OESTROGEN TO GONADOTROPIN SECRETION AND THE POSSIBILITY OF THE ACTIVATION OF DOPAMINERGIC NEURONS FOR ELICITING THIS OESTROGEN EFFECT HAS BEEN STUDIED IN 23 MENOPAUSE WOMEN. THE ADMINISTRATION OF OESTRADIOL BENZOATE (1 MGR I.M) RESULTED IN AN INITIAL DECLINE AT LH AND F.S.H. LEVELS.THESE INITIAL DECLINE BECAME STATISTICALLY SIGNIFICANT IN 6 HOUR AND 8 HOUR RESPECTIVELY FOR LH AND F.S.H. WHEN DOPAMINE AGONIST (LARODOPA 500 MGRX2) WAS ADMINISTRATED 12 H. AND -1 H BEFORE OESTROGENS, RESULTED IN A SIMILAR PATTERN OF LH AND F.S.H. DECLINE, FOLLOWING O.B ADMINISTRATION. THE ADMINISTRATION OF DOPAMINE ANTAGONIST (SULPIRIDE 100 MGRX2 I.M) BEFORE OESTROGEN, DID NOT ALTER THE PATTERN OF THE OESTROGEN ELICITED NEGATIVE FEEDBACK EITHER QUALITAVELY OR QUANTITAVELY. THESE RESULTS ARE SUPPORTING THE VIEW AT LEAST DOPAMINERGIC NEURONS ARE NOT ACTIVATED BY OESTROGEN FOR THEIR NEGATIVE FEEDBACK CONTROL ON GONADOTROPIN SECRETION.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1982

Author dc:creator

• Μπάϊμας, Ιωάννης

• ACTIVATION OF OESTROGEN ON PITU HYPOTHALAMIC HORMONES AND NEUROTRASMITTERS
• Γοναδοτροφίνες
• ΔΡΑΣΗ ΟΙΣΤΡΟΓΟΝΩΝ ΣΤΟ ΥΠΟΦΥΣΙΑΚΟ ΕΠΙΠΕΔΟ
• Εμμηνόπαυση
• Νευρομεταβιβαστές
• ΝΤΟΠΑΜΙΝΕΡΓΙΚΟΙ ΝΕΥΡΩΝΕΣ
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0365

OAI identifier oai:identifier

oai:10442/0365