{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0359"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0359","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ","abstract":"THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. THE PHARMACOKINETIC PARAMETERS ON WHICH THE COMPARATIVE STUDY WAS BASED ARE: ABSORPTION RATE CONSTANT (KA), ELIMINATION RATE CONSTANT (KE), AREA UNDER THE CURVE ([AUC] ), MAXIMUM CONCENTRATION (T MAX), ABSORPTION HALF LIFE (T 1/2/ KA) AND ELIMINATION HALF LIFE (T 1/2 /KE). IT WAS PROVED THAT (1) NONE OF THE ABOVE PRODUCTS EXHIBITS SIGNIFICANT PHARMACOKINETIC DIFFERENCES COMPARED TO THE OTHERS, (2) ALL THE PRODUCTS STUDIED CONTAINED THE PRESCRIBED AMOUNT OF ACTIVE SUBSTANCE.","abstract_html":"THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. THE PHARMACOKINETIC PARAMETERS ON WHICH THE COMPARATIVE STUDY WAS BASED ARE: ABSORPTION RATE CONSTANT (KA), ELIMINATION RATE CONSTANT (KE), AREA UNDER THE CURVE ([AUC] ), MAXIMUM CONCENTRATION (T MAX), ABSORPTION HALF LIFE (T 1/2/ KA) AND ELIMINATION HALF LIFE (T 1/2 /KE). IT WAS PROVED THAT (1) NONE OF THE ABOVE PRODUCTS EXHIBITS SIGNIFICANT PHARMACOKINETIC DIFFERENCES COMPARED TO THE OTHERS, (2) ALL THE PRODUCTS STUDIED CONTAINED THE PRESCRIBED AMOUNT OF ACTIVE SUBSTANCE.","abstract_has_math":false,"creators":["Πρωτόπαπα, Φωτεινή"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1986,"date_issued":"1986","date_published":"1986","updated_at":"2026-07-24T02:25:14Z","subjects":["Aspirin","ASPIRIN PRODUCTS","BIOEQUIVALENCE AND PHARMACOKINETICS","CESPIRE","COLFARIT","NASPIN","SALOSPIR","TRINDER'S METHOD","Ασπιρίνη","ΒΙΟΙΣΟΔΥΝΑΜΙΑ ΚΑΙ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΗ","ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0359"],"render_values":[{"text":"10.12681/eadd/0359","href":"https://doi.org/10.12681/eadd/0359","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0359","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Πρωτόπαπα, Φωτεινή"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1986"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Aspirin","ASPIRIN PRODUCTS","BIOEQUIVALENCE AND PHARMACOKINETICS","CESPIRE","COLFARIT","NASPIN","SALOSPIR","TRINDER'S METHOD","Ασπιρίνη","ΒΙΟΙΣΟΔΥΝΑΜΙΑ ΚΑΙ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΗ","ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0359","http://hdl.handle.net/10442/hedi/0359"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. THE PHARMACOKINETIC PARAMETERS ON WHICH THE COMPARATIVE STUDY WAS BASED ARE: ABSORPTION RATE CONSTANT (KA), ELIMINATION RATE CONSTANT (KE), AREA UNDER THE CURVE ([AUC] ), MAXIMUM CONCENTRATION (T MAX), ABSORPTION HALF LIFE (T 1/2/ KA) AND ELIMINATION HALF LIFE (T 1/2 /KE). IT WAS PROVED THAT (1) NONE OF THE ABOVE PRODUCTS EXHIBITS SIGNIFICANT PHARMACOKINETIC DIFFERENCES COMPARED TO THE OTHERS, (2) ALL THE PRODUCTS STUDIED CONTAINED THE PRESCRIBED AMOUNT OF ACTIVE SUBSTANCE.","ΜΕΛΕΤΗΣΑΜΕ ΣΕ ΥΓΙΕΙΣ ΕΘΕΛΟΝΤΕΣ ΤΗΝ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΗ ΣΥΜΠΕΡΙΦΟΡΑ ΤΩΝ ΑΠΟ ΤΟΥ ΣΤΟΜΑΤΟΣ ΧΟΡΗΓΟΥΜΕΝΩΝ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΤΟ ΚΑΘΕΝΑ ΠΕΡΙΕΧΕΙ 500 MG ΑΚΕΤΥΛΟΣΑΛΙΚΥΛΙΚΟΥ ΟΞΕΩΣ. ΤΑ ΙΔΙΟΣΚΕΥΑΣΜΑΤΑ ΑΥΤΑ ΟΝΟΜΑΣΤΙΚΑ ΗΤΑΝ Η ΑΣΠΙΡΙΝΗ R COLFARIT R KALMOLINE R NASPIN R SALOSPIR K ΚΑΙ CESPIRE K. ΟΙ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΕΣ ΠΑΡΑΜΕΤΡΟΙ ΒΑΣΕΙ ΤΩΝ ΟΠΟΙΩΝ ΕΓΙΝΕ Η ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΕΙΝΑΙ Η ΣΤΑΘΕΡΑ ΤΑΧΥΤΗΤΑΣ ΑΠΟΡΡΟΦΗΣΗΣ (ΚΑ), Η ΣΤΑΘΕΡΑ ΤΑΧΥΤΗΤΑΣ ΑΠΟΒΟΛΗΣ (ΚΕ), ΤΟ ΕΜΒΑΔΟ ΚΑΤΩ ΑΠΟ ΤΗΝ ΚΑΜΠΥΛΗ [AUC] , Ο ΜΕΓΙΣΤΟΣ ΧΡΟΝΟΣ ΑΠΟΡΡΟΦΗΣΗΣ (Τ ΜΑΧ), Η ΜΕΓΙΣΤΗ ΣΥΓΚΕΝΤΡΩΣΗ (C MAX), Η ΗΜΙΠΕΡΙΟΔΟΣ ΑΠΟΡΡΟΦΗΣΗΣ (T 1/2 (KA)) ΚΑΙ Η ΗΜΙΠΕΡΙΟΔΟΣ ΑΠΟΜΑΚΡΥΝΣΗΣ (T1/2 (KE)). ΠΡΟΕΚΥΨΕ ΟΤΙ (1) ΚΑΝΕΝΑ ΙΔΙΟΣΚΕΥΑΣΜΑ ΔΕΝ ΠΑΡΟΥΣΙΑΖΕΙ ΕΝΤΥΠΩΣΙΑΚΕΣ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΕΣ ΔΙΑΦΟΡΕΣ, (2) ΚΑΘΕ ΙΔΙΟΣΚΕΥΑΣΜΑ ΠΕΡΙΕΧΕΙ ΠΡΑΓΜΑΤΙ ΤΟ ΑΝΑΓΡΑΦΟΜΕΝΟ ΠΟΣΟ ΔΡΑΣΤΙΚΗΣ ΟΥΣΙΑΣ."]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ","STUDY OF THE BIOEQUIVALENCE OF ASPIRIN PRODUCTS USED IN GREECE"]}]}],"canonical_facts":{"dc:creator":["Πρωτόπαπα, Φωτεινή"],"dc:date":["1986"],"dc:description":["THE PHARMACOKINETIC BEHAVIOUR OF ORALLY ADMINISTERED PRODUCTS CONTAINING ACETYLSALICYLIC ACID WAS STUDIED IN HUMAN VOLUNTEERS. THE ADMINISTERED DRUGS, EACH OF WHICH CONTAINED 500 MG OF THE ACTIVE SUBSTANCE WERE THE FOLLOWING ASPIRIN R, COLFORT R, SALOSPIR R, NASPIN K, KALACALINE R AND CESPIRE R. THE PHARMACOKINETIC PARAMETERS ON WHICH THE COMPARATIVE STUDY WAS BASED ARE: ABSORPTION RATE CONSTANT (KA), ELIMINATION RATE CONSTANT (KE), AREA UNDER THE CURVE ([AUC] ), MAXIMUM CONCENTRATION (T MAX), ABSORPTION HALF LIFE (T 1/2/ KA) AND ELIMINATION HALF LIFE (T 1/2 /KE). IT WAS PROVED THAT (1) NONE OF THE ABOVE PRODUCTS EXHIBITS SIGNIFICANT PHARMACOKINETIC DIFFERENCES COMPARED TO THE OTHERS, (2) ALL THE PRODUCTS STUDIED CONTAINED THE PRESCRIBED AMOUNT OF ACTIVE SUBSTANCE.","ΜΕΛΕΤΗΣΑΜΕ ΣΕ ΥΓΙΕΙΣ ΕΘΕΛΟΝΤΕΣ ΤΗΝ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΗ ΣΥΜΠΕΡΙΦΟΡΑ ΤΩΝ ΑΠΟ ΤΟΥ ΣΤΟΜΑΤΟΣ ΧΟΡΗΓΟΥΜΕΝΩΝ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΤΟ ΚΑΘΕΝΑ ΠΕΡΙΕΧΕΙ 500 MG ΑΚΕΤΥΛΟΣΑΛΙΚΥΛΙΚΟΥ ΟΞΕΩΣ. ΤΑ ΙΔΙΟΣΚΕΥΑΣΜΑΤΑ ΑΥΤΑ ΟΝΟΜΑΣΤΙΚΑ ΗΤΑΝ Η ΑΣΠΙΡΙΝΗ R COLFARIT R KALMOLINE R NASPIN R SALOSPIR K ΚΑΙ CESPIRE K. ΟΙ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΕΣ ΠΑΡΑΜΕΤΡΟΙ ΒΑΣΕΙ ΤΩΝ ΟΠΟΙΩΝ ΕΓΙΝΕ Η ΣΥΓΚΡΙΤΙΚΗ ΜΕΛΕΤΗ ΕΙΝΑΙ Η ΣΤΑΘΕΡΑ ΤΑΧΥΤΗΤΑΣ ΑΠΟΡΡΟΦΗΣΗΣ (ΚΑ), Η ΣΤΑΘΕΡΑ ΤΑΧΥΤΗΤΑΣ ΑΠΟΒΟΛΗΣ (ΚΕ), ΤΟ ΕΜΒΑΔΟ ΚΑΤΩ ΑΠΟ ΤΗΝ ΚΑΜΠΥΛΗ [AUC] , Ο ΜΕΓΙΣΤΟΣ ΧΡΟΝΟΣ ΑΠΟΡΡΟΦΗΣΗΣ (Τ ΜΑΧ), Η ΜΕΓΙΣΤΗ ΣΥΓΚΕΝΤΡΩΣΗ (C MAX), Η ΗΜΙΠΕΡΙΟΔΟΣ ΑΠΟΡΡΟΦΗΣΗΣ (T 1/2 (KA)) ΚΑΙ Η ΗΜΙΠΕΡΙΟΔΟΣ ΑΠΟΜΑΚΡΥΝΣΗΣ (T1/2 (KE)). ΠΡΟΕΚΥΨΕ ΟΤΙ (1) ΚΑΝΕΝΑ ΙΔΙΟΣΚΕΥΑΣΜΑ ΔΕΝ ΠΑΡΟΥΣΙΑΖΕΙ ΕΝΤΥΠΩΣΙΑΚΕΣ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΕΣ ΔΙΑΦΟΡΕΣ, (2) ΚΑΘΕ ΙΔΙΟΣΚΕΥΑΣΜΑ ΠΕΡΙΕΧΕΙ ΠΡΑΓΜΑΤΙ ΤΟ ΑΝΑΓΡΑΦΟΜΕΝΟ ΠΟΣΟ ΔΡΑΣΤΙΚΗΣ ΟΥΣΙΑΣ."],"dc:identifier":["10.12681/eadd/0359","http://hdl.handle.net/10442/hedi/0359"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["Aspirin","ASPIRIN PRODUCTS","BIOEQUIVALENCE AND PHARMACOKINETICS","CESPIRE","COLFARIT","NASPIN","SALOSPIR","TRINDER'S METHOD","Ασπιρίνη","ΒΙΟΙΣΟΔΥΝΑΜΙΑ ΚΑΙ ΦΑΡΜΑΚΟΚΙΝΗΤΙΚΗ","ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ","Ιατρική και Επιστήμες Υγείας","Βασική Ιατρική","Medical and Health Sciences","Basic Medicine"],"dc:title":["ΜΕΛΕΤΗ ΤΗΣ ΒΙΟΙΣΟΔΥΝΑΜΙΑΣ ΙΔΙΟΣΚΕΥΑΣΜΑΤΩΝ ΑΣΠΙΡΙΝΗΣ ΠΟΥ ΚΥΚΛΟΦΟΡΟΥΝ ΣΤΗΝ ΕΛΛΑΔΑ","STUDY OF THE BIOEQUIVALENCE OF ASPIRIN PRODUCTS USED IN GREECE"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:14Z"}