ΜΕΛΕΤΗ ΤΗΣ ΑΔΕΝΟΣΙΝΟ-ΑΠΑΜΙΝΑΣΗΣ ΤΩΝ ΛΕΜΦΟΚΥΤΤΑΡΩΝ ΕΠΙ ΧΡΟΝΙΑΣ ΝΕΦΡΙΚΗΣ ΑΝΕΠΑΡΚΕΙΑΣ
WE HAVE STUDIED THE ACTIVITY OF ADENOSINO-DEAMINASE IN THE LYMPHOCYTES OF 51 PATIENTS SUFFERING FROM CHRONIC RENAL FAILURE, IN COMPARISON WITH 36 HEALTHY SUBJECTS WHICH WERE USED AS CONTROLS. THE RESULTS ARE AS FOLLOWS: 1. IT WAS FOUND STATISTICALLY VERY SIGNIFICANT DECREASE OF THE ACTIVITY OF THE ENZYME IN 32 UREMIC SUBJECTS UNDER CONSERVATIVE THERAPY. 2 IT WAS NOT FOUND ANY CORRELATION BETWEEN THE ACTIVITY OF THE ENZYME OF THE ENZYME AND THE CREATININE LEVEL INTHE SERUM. 3. THE DECREASE OF THE ACTIVITY OF THE ENZYME IN 19 UREMIC PATIENTS UNDERGONE PERIODICAL HAEMODIALYSIS WAS FOUND STATISTICALLY VERY SIGNIFICANT. 4. THE DIFFERENCE OF ACTIVITY OF THE ENZYME ADA BETWEEN UREMIC SUBJECTS UNDER CONSERVATIVE THERAPY AND THOSE TREATED BY ARTIFICIAL KIDNEY IS NOT STATISTICALLY SIGNIFICANT. THE UREMIC TOXINS WHICH ARE PROBABLY RESPONSIBLE FOR THE IMPAIRMENT OF THE ACTIVITY OF THE ENZYME ARE NOT DIALYSABLE.
ADENOSINE-APAMINASE, Chronic renal failure (CRF), IMMUNOLOGICAL DISTURBANCE, ΑΔΕΝΟΣΙΝΟ-ΑΠΑΜΙΝΑΣΗ, ΑΝΟΣΟΒΙΟΛΟΓΙΚΗ ΔΙΑΤΑΡΑΧΗ, Χρόνια νεφρική ανεπάρκεια (ΧΝΑ), Ιατρική και Επιστήμες Υγείας, Κλινική Ιατρική, Medical and Health Sciences, Clinical Medicine
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National and Kapodistrian University of Athens