ΜΕΛΕΤΗ ΤΗΣ ΠΑΡΑΓΩΓΗΣ IGA1 ΠΡΩΤΕΑΣΗΣ ΑΠΟ MYCOPLASMA ΚΑΙ UREAPLASMA ΑΝΘΡΩΠΟΥ ΚΑΙ ΖΩΩΝ

BECAUSE IMMUNOGLOBULIN A (IGA) IS THE PREDOMINANT IMMUNOGLOBULIN AT MUCOSAL SURFACES, IGA PROTEASES PRODUCED BY PATHOGENIC BACTERIA ARE CONSIDERED POTENTIALVIRULENCE FACTORS FOR ORGANISMS THAT CAUSE DISEASE OR GAIN ENTRY AT MUCOUS MEMBRANES. TO DETERMINE THE ROLE OF IGA PROTEASE IN THE PATHOGENICITY OF MYCOPLASMAL DISEASE, A VARIETY OF HUMAN AND ANIMAL MYCOPLASMA AND UREAPLASMA SPECIES WERE EXAMINED FOR IGA PROTEASE ACTIVITY WITH HUMAN, MURINE, PORCINE AND CANINEIGA. NONE OF THE MYCOPLASMA SPECIES EXAMINED SHOWED DETECTABLE IGA PROTEASE ACTIVITY WITH ANY OF THE IGAS TESTED. TWENTY SEVEN STRAINS OF UREAPLASMA UREALYTICUM ISOLATED FROM HUMAN UROGENITAL TISSUES CLEARED HUMAN IGA1, BUT NO CLEAVAGE OF HUMAM IGA2 OR MURINE, PORCINE OR CANINE IGA WAS OBSERVED. UREAPLASMA ISOLATED FROM NONHUMAN HOSTS DID NOT CLEAVE HUMAN IGA1. TWO STRAINS OF CANINE UREAPLASMA WERE ABLE TO CLEAVE CANINE IGA BUT NOT MURINE IGA. THUS UREAPLASMA FROM OTHER SPECIES CAN PRODUCE IGA PROTEASE, BUT THE SPECIFICITY OF THE ENZYME WAS RESTRICTED TO THE IGA OF THE APPROPRIATE HOST. THIS FINDING SUGGESTS THAT IGA PROTEASES COULD PLAY A ROLE IN THE SELECTIVE HOST SPECIFICITY OF MUCOSAL PATHOGENS.

Grantor dc:publisher

University of Patras

Year dc:date

1986

Author dc:creator

• Καπάταγη-Ζούμπου, Καίτη

• IGA1 ΠΡΩΤΕΑΣΗ
• Βακτηριολογία
• ΕΙΔΙΚΟΤΗΤΑ ΤΟΥ ΕΝΖΥΜΟΥ
• Μυκοπλάσματα
• ΟΥΡΕΑΠΛΑΣΜΑΤΑ
• CANINE UREAPLASMA
• HOST SPECIFICITY
• IGA1 PROTEASES
• MYCOPLASMA
• Ureaplasma urealyticum
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0210

OAI identifier oai:identifier

oai:10442/0210