IN VITRO ΚΑΙ IN VIVO ΜΕΛΕΤΕΣ ΤΗΣ ΕΠΙΔΡΑΣΗΣ ΤΩΝ ΠΡΩΤΕΙΝΩΝ ΣΤΗ ΔΙΑΛΥΤΟΠΟΙΗΣΗ ΚΑΙ ΑΠΟΡΡΟΦΗΣΗ ΔΙΚΟΥΜΑΡΟΛΗΣ ΝΙΤΡΟΦΟΥΡΑΝΤΟΙΝΗΣ ΚΑΙ ΣΟΥΛΦΑΜΕΘΙΖΟΛΗΣ

IN THIS PHD THESIS THE MECHANISMS WITH WHICH SMALL QUANTITIES OF PROTEINS CAN ALTER THE BIOAVAILABILITY OF POORLY WATER SOLUBLE DRUGS (AT CONCENTRATIONS SIMILAR TO THOSE THEY ARE MET IN FOODSTUFFS) WERE INVESTIGATED. NITROFURANTOIN, DICUMAROL AND SULFAMETHIZOLE WERE CHOSEN AS MODEL DRUGS. BOVINE SERUM ALBUMIN AND CASEIN WERE USED AS MODEL PROTEINS. THE IN VITRO STUDIES INCLUDED DISSOLUTION AND TRANSPORT OF ALL DRUGS THOUGH DIALYSIS MEMBRANES. MOREOVER PROTEIN BINDING, SOLUBILITY, VISCOSITY AND SURFACE TENSION MEASUREMENTS WERE MADE AS WELLAS PARTICLE SIZE ANALYSIS OF THE POWDERS. THE EFFECT OF LOW FAT MILK ON THE BIOAVAILABILITY WAS ALSO STUDIED. FINALLY, A NEW DOSAGE FORM WAS SUGGESTED: THEFREEZE DRIED (LYOPHILIZED) DRUG-MILK FORMULATIONS SHOWED FASTER AND MORE CONSISTENT ABSORPTION THAN OTHER TYPICAL DOSAGE FORMS AND ARE PROMISING AS A NEW DRUG DELIVERY SYSTEM.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1986

Authors dc:creator

• Ρέππας, Χρήστος
• Reppas, Christos

• Βιοδιαθεσιμότητα
• Βιοφαρμακευτική
• ΛΥΟΦΙΛΟΠΟΙΗΣΗ-ΓΑΛΑ
• Φαρμακευτική
• BIOAVAILABILITY-EFFECT OF MILK INTAKE
• FREEZE DRIED DRUG-MILK FORMULATION
• LYOPHILIZATION-MILK
• Ιατρική και Επιστήμες Υγείας
• Βασική Ιατρική
• Medical and Health Sciences
• Basic Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0184

OAI identifier oai:identifier

oai:10442/0184