Η ΕΠΙΔΡΑΣΗ ΤΗΣ ΝΤΟΠΑΜΙΝΗΣ ΣΤΗΝ ΕΚΚΡΙΣΗ ΤΗΣ TSH ΣΕ ΑΣΘΕΝΕΙΣ ΜΕ ΧΡΟΝΙΑ ΜΗ ΘΥΡΕΟΕΙΔΙΚΑ ΝΟΣΗΜΑΤΑ

PATIENTS WITH CHRONIC NON THYROIDAL DISEASES EXHIBIT A DECREASE IN SERUM T3, AN INCREASE IN SERUM REVERSE T3 AND NORMAL OR REDUCED BASAL OR STIMULATED TSH SECRETION BY TRH. IT IS POSSIBLE THAT THE DECREASED TSH RESPONSE TO TRH IS DUE TO AN INCREASED DOPAMINERGIC TONE TO THE PITUATARY. TO EXAMINE THIS POSSIBILITY WE STUDIED 14 PATIENTS WITH VARIOUS CHRONIC NON THYROIDAL DISEASES AND 8 HEALTHY AGE AND SEX MATCHED CONTROLS. WE MEASURED TSH AND T3 AND T4 BEFORE AND AFTER ADMINISTRATION OF TRH. THE SAME MEASUREMENTS WERE DONE SEVEN DAYS LATER AFTER ADMINISTRATION OF TRH AND METOCLOPRAMIDE. THE MAXIMUM RESPONSE TO TRH WASSIMILAR IN BOTH GROUPS. METOCLOPRAMIDE ADMINISTRATION HAD NO EFFECT ON TSH SECRETION OF THE PATIENTS BUT INCREASED CONTROLS' TSH. PATIENTS WITH LOW BASAL SERUM T3 DISPLAYED A VERY SMALL INCREASE IN STIMULATED SERUM T3. WE THEREFORE CONCLUDE THAT ENDOGENOUS DOPAMINERGIC TONE HAS NO EFFECT ON TSH SECRETION IN PATIENTS WITH CHRONIC NON THYROIDAL ILLNESS. THE DECREASED THYROIDAL RESPONSE OF T3 TO ENDOGENOUS TSH IN PATIENTS WITH SEVERE NON THYROIDAL ILLNESS SUGGESTS THAT THE INTRATHYROIDAL T3 POOL IS DECREASED IN THESE PATIENTS OR THE CONVERSION OF T4 TO T3 INTO THE THYROID IS IMPAIRED AS WELL.

Grantor dc:publisher

University of Patras

Year dc:date

1987

Authors dc:creator

• Labropoulou-Karatza, Chryssoula
• Λαμπροπούλου-Καρατζά, Χρυσούλα

• ΕΚΚΡΙΣΗ TSH
• Ιατρική
• ΝΤΟΠΑΜΙΝΕΡΓΙΚΗ ΕΠΙΔΡΑΣΗ
• DOPAMINERGIC MODULATIONS
• ECETHYROID SICK
• TSH SECRETIONS
• Ιατρική και Επιστήμες Υγείας
• Κλινική Ιατρική
• Medical and Health Sciences
• Clinical Medicine

Language dc:language

gre

Identifier

10.12681/eadd/0121

OAI identifier oai:identifier

oai:10442/0121