{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0079"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0079","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΣΥΜΒΟΛΗ ΣΤΗΝ ΜΕΛΕΤΗ ΤΩΝ HLA-A, B, C ΚΑΙ DR ΑΝΤΙΓΟΝΩΝ ΣΤΙΣ ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ","abstract":"A STUDY OF THE FREQUENCY OF HLA-A1B1C AND DR ANTIGEΝS WAS PERFORMED IN 106 GREEK PATIENTS AFFECTED FROM RECURRENT ORAL ULCERATION (ROU) AND 120 MATCHED CONTROLS OF THE SAME NATIONALITY. THIS INVESTIGATION REVEALED THAT HLA-DRS ANTIGEN IS MORE FREQUENT IN PATIENTS (PC < 0,01) AND THUS IT MAY BE CONSIDERED AS A GENETIC MARKER OF THE DISEASE IN GREEK POPULATION. STATISTICALLY INCREASED WERE ALSO FOUND HLA-A28 (PC < 0,05) AND HLA-CW2 (PC <0,05) BUT HLA-DR4 WAS FOUNDSTATISTICALLY SIGNIFICANT DECREASED (PC < 0,05) IN PATIENTS WITH ROU. AS A GENERAL APPROACH WE MAY POSTULATE THAT GENETIC FACTORS CLOSELY RELATED WITH HLA SYSTEM PLAY A RATHER IMPORTANT ROLE IN THE DEVELOPMENT OF RECURRENT ORAL ULCERATION.","abstract_html":"A STUDY OF THE FREQUENCY OF HLA-A1B1C AND DR ANTIGEΝS WAS PERFORMED IN 106 GREEK PATIENTS AFFECTED FROM RECURRENT ORAL ULCERATION (ROU) AND 120 MATCHED CONTROLS OF THE SAME NATIONALITY. THIS INVESTIGATION REVEALED THAT HLA-DRS ANTIGEN IS MORE FREQUENT IN PATIENTS (PC &lt; 0,01) AND THUS IT MAY BE CONSIDERED AS A GENETIC MARKER OF THE DISEASE IN GREEK POPULATION. STATISTICALLY INCREASED WERE ALSO FOUND HLA-A28 (PC &lt; 0,05) AND HLA-CW2 (PC &lt;0,05) BUT HLA-DR4 WAS FOUNDSTATISTICALLY SIGNIFICANT DECREASED (PC &lt; 0,05) IN PATIENTS WITH ROU. AS A GENERAL APPROACH WE MAY POSTULATE THAT GENETIC FACTORS CLOSELY RELATED WITH HLA SYSTEM PLAY A RATHER IMPORTANT ROLE IN THE DEVELOPMENT OF RECURRENT ORAL ULCERATION.","abstract_has_math":false,"creators":["Αλμπανίδου-Φαρμάκη, Ελένη","Albanidou-Farmaki, Eleni"],"institution":"Aristotle University Of Thessaloniki (AUTH)","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1986,"date_issued":"1986","date_published":"1986","updated_at":"2026-07-24T02:25:27Z","subjects":["HLA-ΑΝΤΙΓΟΝΑ","ΑΝΤΙΓΟΝΙΚΗ ΣΥΧΝΟΤΗΤΑ","ΑΠΛΟΤΥΠΙΚΗ ΣΥΧΝΟΤΗΤΑ","Μείζον σύστημα ιστοσυμβατότητας","ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ","ANTIGEN FREQUENCY","HLA-ANTIGENS","MHC-MAJOR HISTOCOMPATIBILITY COMPLEX","RECURRENT ORAL ULCERATION","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0079"],"render_values":[{"text":"10.12681/eadd/0079","href":"https://doi.org/10.12681/eadd/0079","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0079","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Αλμπανίδου-Φαρμάκη, Ελένη","Albanidou-Farmaki, Eleni"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1986"]},{"key":"dc:publisher","label":"Institution","values":["Aristotle University Of Thessaloniki (AUTH)","Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["HLA-ΑΝΤΙΓΟΝΑ","ΑΝΤΙΓΟΝΙΚΗ ΣΥΧΝΟΤΗΤΑ","ΑΠΛΟΤΥΠΙΚΗ ΣΥΧΝΟΤΗΤΑ","Μείζον σύστημα ιστοσυμβατότητας","ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ","ANTIGEN FREQUENCY","HLA-ANTIGENS","MHC-MAJOR HISTOCOMPATIBILITY COMPLEX","RECURRENT ORAL ULCERATION","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0079","http://hdl.handle.net/10442/hedi/0079"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["A STUDY OF THE FREQUENCY OF HLA-A1B1C AND DR ANTIGEΝS WAS PERFORMED IN 106 GREEK PATIENTS AFFECTED FROM RECURRENT ORAL ULCERATION (ROU) AND 120 MATCHED CONTROLS OF THE SAME NATIONALITY. THIS INVESTIGATION REVEALED THAT HLA-DRS ANTIGEN IS MORE FREQUENT IN PATIENTS (PC < 0,01) AND THUS IT MAY BE CONSIDERED AS A GENETIC MARKER OF THE DISEASE IN GREEK POPULATION. STATISTICALLY INCREASED WERE ALSO FOUND HLA-A28 (PC < 0,05) AND HLA-CW2 (PC <0,05) BUT HLA-DR4 WAS FOUNDSTATISTICALLY SIGNIFICANT DECREASED (PC < 0,05) IN PATIENTS WITH ROU. AS A GENERAL APPROACH WE MAY POSTULATE THAT GENETIC FACTORS CLOSELY RELATED WITH HLA SYSTEM PLAY A RATHER IMPORTANT ROLE IN THE DEVELOPMENT OF RECURRENT ORAL ULCERATION.","Η ΜΕΛΕΤΗ ΜΑΣ ΑΠΟΤΕΛΕΙ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ ΤΩΝ HLA- A1B1C ΚΑΙ DR ΑΝΤΙΓΟΝΩΝ ΣΕ 106 ΑΣΘΕΝΕΙΣ ΜΕ ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ ΕΛΛΗΝΙΚΗΣ ΚΑΤΑΓΩΓΗΣ ΚΑΙ ΕΘΝΙΚΟΤΗΤΑΣΚΑΙ ΣΕ 120 ΜΑΡΤΥΡΕΣ. Η ΕΡΕΥΝΑ ΜΑΣ ΕΔΕΙΞΕ ΟΤΙ ΤΟ HLA-DRS ΑΝΤΙΓΟΝΟ ΕΜΦΑΝΙΖΕΙ ΤΗ ΜΕΓΑΛΥΤΕΡΗ ΣΥΧΝΟΤΗΤΑ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ (PC < 0,001) ΚΑΙ ΑΠΟΤΕΛΕΙ ΤΟ ΓΕΝΕΤΙΚΟ ΔΕΙΚΤΗ ΤΗΣ ΝΟΣΟΥ ΣΤΟΥΣ ΕΛΛΗΝΕΣ. ΣΤΑΤΙΣΤΙΚΑ ΣΗΜΑΝΤΙΚΗ ΑΥΞΗΣΗ ΕΜΦΑΝΙΖΟΥΝ ΤΑ ΑΝΤΙΓΟΝΑ HLA-A28 (PC < 0,05), TO HLA-CW2 (PC < 0,05), ΕΝΩ ΤΟ HLA- DR4 ΑΝΤΙΓΟΝΟ ΕΜΦΑΝΙΖΕΙ ΣΤΑΤΙΣΤΙΚΑ ΣΗΜΑΝΤΙΚΗ ΕΛΑΤΤΩΣΗ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ ΣΕ ΣΧΕΣΗ ΜΕ ΤΟΥΣ ΜΑΡΤΥΡΕΣ (PC < 0,05). ΑΠΟ ΤΑ ΠΑΡΑΠΑΝΩ ΑΞΙΟΛΟΓΟΥΜΕ ΟΤΙ ΓΕΝΕΤΙΚΟΙ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΕΙΝΑΙ ΣΤΕΝΑ ΣΥΝΔΕΔΕΜΕΝΟΙ ΜΕ ΤΟ ΣΥΣΤΗΜΑ HLA ΠΑΙΖΟΥΝ ΡΟΛΟ ΣΤΗΝ ΕΜΦΑΝΙΣΗ ΤΩΝ ΥΠΟΤΡΟΠΙΑΖΟΥΣΩΝ ΑΦΘΩΝ."]},{"key":"dc:title","label":"Title","values":["ΣΥΜΒΟΛΗ ΣΤΗΝ ΜΕΛΕΤΗ ΤΩΝ HLA-A, B, C ΚΑΙ DR ΑΝΤΙΓΟΝΩΝ ΣΤΙΣ ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ","HLA-A, B, C AND DR ANTIGENS IN RECURRENT ORAL ULCERATION"]}]}],"canonical_facts":{"dc:creator":["Αλμπανίδου-Φαρμάκη, Ελένη","Albanidou-Farmaki, Eleni"],"dc:date":["1986"],"dc:description":["A STUDY OF THE FREQUENCY OF HLA-A1B1C AND DR ANTIGEΝS WAS PERFORMED IN 106 GREEK PATIENTS AFFECTED FROM RECURRENT ORAL ULCERATION (ROU) AND 120 MATCHED CONTROLS OF THE SAME NATIONALITY. THIS INVESTIGATION REVEALED THAT HLA-DRS ANTIGEN IS MORE FREQUENT IN PATIENTS (PC < 0,01) AND THUS IT MAY BE CONSIDERED AS A GENETIC MARKER OF THE DISEASE IN GREEK POPULATION. STATISTICALLY INCREASED WERE ALSO FOUND HLA-A28 (PC < 0,05) AND HLA-CW2 (PC <0,05) BUT HLA-DR4 WAS FOUNDSTATISTICALLY SIGNIFICANT DECREASED (PC < 0,05) IN PATIENTS WITH ROU. AS A GENERAL APPROACH WE MAY POSTULATE THAT GENETIC FACTORS CLOSELY RELATED WITH HLA SYSTEM PLAY A RATHER IMPORTANT ROLE IN THE DEVELOPMENT OF RECURRENT ORAL ULCERATION.","Η ΜΕΛΕΤΗ ΜΑΣ ΑΠΟΤΕΛΕΙ ΔΙΕΡΕΥΝΗΣΗ ΤΗΣ ΣΥΧΝΟΤΗΤΑΣ ΤΩΝ HLA- A1B1C ΚΑΙ DR ΑΝΤΙΓΟΝΩΝ ΣΕ 106 ΑΣΘΕΝΕΙΣ ΜΕ ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ ΕΛΛΗΝΙΚΗΣ ΚΑΤΑΓΩΓΗΣ ΚΑΙ ΕΘΝΙΚΟΤΗΤΑΣΚΑΙ ΣΕ 120 ΜΑΡΤΥΡΕΣ. Η ΕΡΕΥΝΑ ΜΑΣ ΕΔΕΙΞΕ ΟΤΙ ΤΟ HLA-DRS ΑΝΤΙΓΟΝΟ ΕΜΦΑΝΙΖΕΙ ΤΗ ΜΕΓΑΛΥΤΕΡΗ ΣΥΧΝΟΤΗΤΑ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ (PC < 0,001) ΚΑΙ ΑΠΟΤΕΛΕΙ ΤΟ ΓΕΝΕΤΙΚΟ ΔΕΙΚΤΗ ΤΗΣ ΝΟΣΟΥ ΣΤΟΥΣ ΕΛΛΗΝΕΣ. ΣΤΑΤΙΣΤΙΚΑ ΣΗΜΑΝΤΙΚΗ ΑΥΞΗΣΗ ΕΜΦΑΝΙΖΟΥΝ ΤΑ ΑΝΤΙΓΟΝΑ HLA-A28 (PC < 0,05), TO HLA-CW2 (PC < 0,05), ΕΝΩ ΤΟ HLA- DR4 ΑΝΤΙΓΟΝΟ ΕΜΦΑΝΙΖΕΙ ΣΤΑΤΙΣΤΙΚΑ ΣΗΜΑΝΤΙΚΗ ΕΛΑΤΤΩΣΗ ΣΤΟΥΣ ΑΣΘΕΝΕΙΣ ΣΕ ΣΧΕΣΗ ΜΕ ΤΟΥΣ ΜΑΡΤΥΡΕΣ (PC < 0,05). ΑΠΟ ΤΑ ΠΑΡΑΠΑΝΩ ΑΞΙΟΛΟΓΟΥΜΕ ΟΤΙ ΓΕΝΕΤΙΚΟΙ ΠΑΡΑΓΟΝΤΕΣ ΠΟΥ ΕΙΝΑΙ ΣΤΕΝΑ ΣΥΝΔΕΔΕΜΕΝΟΙ ΜΕ ΤΟ ΣΥΣΤΗΜΑ HLA ΠΑΙΖΟΥΝ ΡΟΛΟ ΣΤΗΝ ΕΜΦΑΝΙΣΗ ΤΩΝ ΥΠΟΤΡΟΠΙΑΖΟΥΣΩΝ ΑΦΘΩΝ."],"dc:identifier":["10.12681/eadd/0079","http://hdl.handle.net/10442/hedi/0079"],"dc:language":["gre"],"dc:publisher":["Aristotle University Of Thessaloniki (AUTH)","Αριστοτέλειο Πανεπιστήμιο Θεσσαλονίκης (ΑΠΘ)"],"dc:subject":["HLA-ΑΝΤΙΓΟΝΑ","ΑΝΤΙΓΟΝΙΚΗ ΣΥΧΝΟΤΗΤΑ","ΑΠΛΟΤΥΠΙΚΗ ΣΥΧΝΟΤΗΤΑ","Μείζον σύστημα ιστοσυμβατότητας","ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ","ANTIGEN FREQUENCY","HLA-ANTIGENS","MHC-MAJOR HISTOCOMPATIBILITY COMPLEX","RECURRENT ORAL ULCERATION","Ιατρική και Επιστήμες Υγείας","Κλινική Ιατρική","Medical and Health Sciences","Clinical Medicine"],"dc:title":["ΣΥΜΒΟΛΗ ΣΤΗΝ ΜΕΛΕΤΗ ΤΩΝ HLA-A, B, C ΚΑΙ DR ΑΝΤΙΓΟΝΩΝ ΣΤΙΣ ΥΠΟΤΡΟΠΙΑΖΟΥΣΕΣ ΑΦΘΕΣ","HLA-A, B, C AND DR ANTIGENS IN RECURRENT ORAL ULCERATION"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:27Z"}