{"id":{"repo_id":"greece","oai_identifier":"oai:10442/0037"},"canonical_url":"https://search.dev.ndltd.org/etd/greece/oai:10442/0037","repository":{"repo_id":"greece","name":"Greek National Archive of PhD Theses","base_url":"https://phdtheses.ekt.gr/eadd_oai/request"},"display":{"title":"ΜΕΛΕΤΗ ΣΥΠΛΟΚΩΝ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5' - ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ","abstract":"IN THIS THESIS THE INTERACTION OF METAL IONS WITH ADENOSINE MONOPHOSPHATE, 6-MERCAPTOPURINE AND ITS RIBOSIDE - ANTICANCER DRUGS - AND 8-AZAPURINES IS INVESTIGATED. WE HAVE PREPARED THE COMPLEXES OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. THE METAL TO LIGAND RATIO IN ALL THESE COMPLEXES IS 1:1. WE HAVE ALSO PREPARED NINE COMPLEXES (1:1, 1:2) OF 6-MERCAPTOPURINE AND ITS RIBOSIDE WITH RU3+, RB3+, IR3+, R. WEHAVE PREPARED THE COMPLEXES OF ZN2+, PT2+ WITH 8-AZAADENINE, CU2+, PD2+, AU3+WITH 8-AZAGUANINE AND CO2+, AU3+, AU+ WITH 8-AZAHYPOXANTHINE. ALL THESE COMPLEXES HAVE BEEN STUDIED WITH INTRACED SPECTROSCOPY, DIFFUSE REFLECTANCE, FLUORESCENCE, NUCLEAR MAGNETIC RESONANCE AND MOSSBAUER SPECTROSCOPY, MAGNETIC SUSCEPTIBILITY AND CONDUCTIVITY MEASUREMENTS, IN ORDER TO FIND THE POSITION OF THE LIGAND TO WHICH THE METAL IS ATTACHED.","abstract_html":"IN THIS THESIS THE INTERACTION OF METAL IONS WITH ADENOSINE MONOPHOSPHATE, 6-MERCAPTOPURINE AND ITS RIBOSIDE - ANTICANCER DRUGS - AND 8-AZAPURINES IS INVESTIGATED. WE HAVE PREPARED THE COMPLEXES OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. THE METAL TO LIGAND RATIO IN ALL THESE COMPLEXES IS 1:1. WE HAVE ALSO PREPARED NINE COMPLEXES (1:1, 1:2) OF 6-MERCAPTOPURINE AND ITS RIBOSIDE WITH RU3+, RB3+, IR3+, R. WEHAVE PREPARED THE COMPLEXES OF ZN2+, PT2+ WITH 8-AZAADENINE, CU2+, PD2+, AU3+WITH 8-AZAGUANINE AND CO2+, AU3+, AU+ WITH 8-AZAHYPOXANTHINE. ALL THESE COMPLEXES HAVE BEEN STUDIED WITH INTRACED SPECTROSCOPY, DIFFUSE REFLECTANCE, FLUORESCENCE, NUCLEAR MAGNETIC RESONANCE AND MOSSBAUER SPECTROSCOPY, MAGNETIC SUSCEPTIBILITY AND CONDUCTIVITY MEASUREMENTS, IN ORDER TO FIND THE POSITION OF THE LIGAND TO WHICH THE METAL IS ATTACHED.","abstract_has_math":false,"creators":["Grigoratou, Andriani","Γρηγοράτου, Ανδριανή"],"institution":"National and Kapodistrian University of Athens","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1986,"date_issued":"1986","date_published":"1986","updated_at":"2026-07-24T02:25:14Z","subjects":["5' ΑΝΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ","6 - Μερκαπτοπουρίνη","8-ΑΖΑΑΔΕΝΙΝΗ","8-ΑΖΑΓΟΥΑΝΙΝΗ","8-ΑΖΑΠΟΥΡΙΝΕΣ","8-ΑΖΑΥΠΟΞΑΝΘΙΝΗ","ΡΙΒΟΣΙΔΙΟ ΤΗΣ 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗΣ","ΣΥΜΠΛΟΚΑ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ","6 - Mercaptopurine","6-MERCAPTOPURINE RIBOSIDE","8-AZAADENINE","8-AZAGUANINE","8-AZAHYPOXANTHINE","8-AZAPURINES","METAL IONS COMPLEXES","Φυσικές Επιστήμες","Χημεία","Natural Sciences","Chemical Sciences"],"languages":["gre"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0037"],"render_values":[{"text":"10.12681/eadd/0037","href":"https://doi.org/10.12681/eadd/0037","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/10442/hedi/0037","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Grigoratou, Andriani","Γρηγοράτου, Ανδριανή"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["1986"]},{"key":"dc:publisher","label":"Institution","values":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"]},{"key":"dc:type","label":"Dc Type","values":["PhD Thesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["5' ΑΝΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ","6 - Μερκαπτοπουρίνη","8-ΑΖΑΑΔΕΝΙΝΗ","8-ΑΖΑΓΟΥΑΝΙΝΗ","8-ΑΖΑΠΟΥΡΙΝΕΣ","8-ΑΖΑΥΠΟΞΑΝΘΙΝΗ","ΡΙΒΟΣΙΔΙΟ ΤΗΣ 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗΣ","ΣΥΜΠΛΟΚΑ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ","6 - Mercaptopurine","6-MERCAPTOPURINE RIBOSIDE","8-AZAADENINE","8-AZAGUANINE","8-AZAHYPOXANTHINE","8-AZAPURINES","METAL IONS COMPLEXES","Φυσικές Επιστήμες","Χημεία","Natural Sciences","Chemical Sciences"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["gre"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["10.12681/eadd/0037","http://hdl.handle.net/10442/hedi/0037"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["IN THIS THESIS THE INTERACTION OF METAL IONS WITH ADENOSINE MONOPHOSPHATE, 6-MERCAPTOPURINE AND ITS RIBOSIDE - ANTICANCER DRUGS - AND 8-AZAPURINES IS INVESTIGATED. WE HAVE PREPARED THE COMPLEXES OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. THE METAL TO LIGAND RATIO IN ALL THESE COMPLEXES IS 1:1. WE HAVE ALSO PREPARED NINE COMPLEXES (1:1, 1:2) OF 6-MERCAPTOPURINE AND ITS RIBOSIDE WITH RU3+, RB3+, IR3+, R. WEHAVE PREPARED THE COMPLEXES OF ZN2+, PT2+ WITH 8-AZAADENINE, CU2+, PD2+, AU3+WITH 8-AZAGUANINE AND CO2+, AU3+, AU+ WITH 8-AZAHYPOXANTHINE. ALL THESE COMPLEXES HAVE BEEN STUDIED WITH INTRACED SPECTROSCOPY, DIFFUSE REFLECTANCE, FLUORESCENCE, NUCLEAR MAGNETIC RESONANCE AND MOSSBAUER SPECTROSCOPY, MAGNETIC SUSCEPTIBILITY AND CONDUCTIVITY MEASUREMENTS, IN ORDER TO FIND THE POSITION OF THE LIGAND TO WHICH THE METAL IS ATTACHED.","ΣΤΗ ΔΙΑΤΡΙΒΗ ΕΧΕΙ ΓΙΝΕΙ ΜΕΛΕΤΗ ΤΗΣ ΑΛΛΗΛΕΠΙΔΡΑΣΗΣ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5'-ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ - ΕΧΟΥΝ ΚΥΤΤΑΡΟΣΤΑΤΙΚΗ ΔΡΑΣΗ - ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ - ΠΑΡΟΥΣΙΑΖΟΥΝ ΕΥΡΥ ΦΑΣΜΑ ΦΑΡΜΑΚΟΛΟΓΙΚΩΝ ΕΦΑΡΜΟΓΩΝ. ΠΑΡΑΣΚΕΥΑΣΘΗΚΑΝ ΤΑ ΣΥΜΠΛΟΚΑ MN2+, FE2+, ZN2+, PD2+, CD2+, PB2+, CR3+, PR3+, SM3+, TB3+, UO2 2+ ΜΕ ΑΝΑΛΟΓΙΑ ΜΕΤΑΛΛΟ : 5'-ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ 1:1. ΠΑΡΑΣΚΕΥΑΣΘΗΚΑΝ ΕΠΙΣΗΣ ΕΝΝΕΑ ΣΥΜΠΛΟΚΑ (1:1 ΚΑΙ 1:2 ΜΕ ΤΗΝ 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ, 20 ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ RN3+, RH3+, JR3+, RN2+. ΠΑΡΑΣΚΕΥΑΣΘΗΚΑΝ ΕΠΙΣΗΣ ΤΑ ΣΥΜΠΛΟΚΑ PT2+, ZN2+ ΜΕ 8- ΑΖΑΑΔΕΝΙΝΗ, CU2+, PD2+, AU3+ ΜΕ 8-ΑΖΟΓΟΝΑΝΙΝΗ ΚΑΙ CO2+, AU3+, AU+ ΜΕ 8- ΑΖΟΥΠΟΞΑΝΘΙΝΗ. ΤΑ ΣΥΜΠΛΟΚΑ ΑΥΤΑ ΜΕΛΕΤΗΘΗΚΑΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΥΠΕΡΥΘΡΟΥ, ΔΙΑΧΥΤΙΚΗ ΑΝΑΚΛΑΣΗΣ, ΦΘΟΡΙΣΜΟΥ ΠΥΡΗΝΙΚΟΥ ΜΑΓΝΗΤΙΚΟΥ ΣΥΝΤΟΝΙΣΜΟΥ MOSSBAUER ΚΑΙ ΕΓΙΝΑΝ ΜΕΤΡΗΣΕΙΣ ΑΓΩΓΙΜΟΤΗΤΑΣ ΚΑΙ ΜΑΓΝΗΤΙΚΗΣ ΕΠΙΔΕΚΤΙΚΟΤΗΤΑΣ, ΩΣΤΕ ΝΑΒΡΕΘΟΥΝ ΟΙ ΘΕΣΕΙΣ ΣΥΝΔΕΣΗΣ ΤΟΥ ΜΕΤΑΛΛΟΥ ΜΕ ΤΟΝ ΥΠΟΚΑΤΑΣΤΑΤΗ."]},{"key":"dc:title","label":"Title","values":["ΜΕΛΕΤΗ ΣΥΠΛΟΚΩΝ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5' - ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ","STUDY OF METAL IONS COMPLEXES WITH 5'- ADENOSINE MONOPHOSPHATE 6-MERCAPTODURINEAND ITS RIBOSIDE AND 8-AZAPURINES"]}]}],"canonical_facts":{"dc:creator":["Grigoratou, Andriani","Γρηγοράτου, Ανδριανή"],"dc:date":["1986"],"dc:description":["IN THIS THESIS THE INTERACTION OF METAL IONS WITH ADENOSINE MONOPHOSPHATE, 6-MERCAPTOPURINE AND ITS RIBOSIDE - ANTICANCER DRUGS - AND 8-AZAPURINES IS INVESTIGATED. WE HAVE PREPARED THE COMPLEXES OF 5'- ADENOSINE MONOPHOSPHATE WITH MN2+, FE2+, ZN2+, PB2+, CD2+, PD2+, CE3+, PR3+, SM3+, TB3+, MO2 2+. THE METAL TO LIGAND RATIO IN ALL THESE COMPLEXES IS 1:1. WE HAVE ALSO PREPARED NINE COMPLEXES (1:1, 1:2) OF 6-MERCAPTOPURINE AND ITS RIBOSIDE WITH RU3+, RB3+, IR3+, R. WEHAVE PREPARED THE COMPLEXES OF ZN2+, PT2+ WITH 8-AZAADENINE, CU2+, PD2+, AU3+WITH 8-AZAGUANINE AND CO2+, AU3+, AU+ WITH 8-AZAHYPOXANTHINE. ALL THESE COMPLEXES HAVE BEEN STUDIED WITH INTRACED SPECTROSCOPY, DIFFUSE REFLECTANCE, FLUORESCENCE, NUCLEAR MAGNETIC RESONANCE AND MOSSBAUER SPECTROSCOPY, MAGNETIC SUSCEPTIBILITY AND CONDUCTIVITY MEASUREMENTS, IN ORDER TO FIND THE POSITION OF THE LIGAND TO WHICH THE METAL IS ATTACHED.","ΣΤΗ ΔΙΑΤΡΙΒΗ ΕΧΕΙ ΓΙΝΕΙ ΜΕΛΕΤΗ ΤΗΣ ΑΛΛΗΛΕΠΙΔΡΑΣΗΣ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5'-ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ - ΕΧΟΥΝ ΚΥΤΤΑΡΟΣΤΑΤΙΚΗ ΔΡΑΣΗ - ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ - ΠΑΡΟΥΣΙΑΖΟΥΝ ΕΥΡΥ ΦΑΣΜΑ ΦΑΡΜΑΚΟΛΟΓΙΚΩΝ ΕΦΑΡΜΟΓΩΝ. ΠΑΡΑΣΚΕΥΑΣΘΗΚΑΝ ΤΑ ΣΥΜΠΛΟΚΑ MN2+, FE2+, ZN2+, PD2+, CD2+, PB2+, CR3+, PR3+, SM3+, TB3+, UO2 2+ ΜΕ ΑΝΑΛΟΓΙΑ ΜΕΤΑΛΛΟ : 5'-ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ 1:1. ΠΑΡΑΣΚΕΥΑΣΘΗΚΑΝ ΕΠΙΣΗΣ ΕΝΝΕΑ ΣΥΜΠΛΟΚΑ (1:1 ΚΑΙ 1:2 ΜΕ ΤΗΝ 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ, 20 ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ RN3+, RH3+, JR3+, RN2+. ΠΑΡΑΣΚΕΥΑΣΘΗΚΑΝ ΕΠΙΣΗΣ ΤΑ ΣΥΜΠΛΟΚΑ PT2+, ZN2+ ΜΕ 8- ΑΖΑΑΔΕΝΙΝΗ, CU2+, PD2+, AU3+ ΜΕ 8-ΑΖΟΓΟΝΑΝΙΝΗ ΚΑΙ CO2+, AU3+, AU+ ΜΕ 8- ΑΖΟΥΠΟΞΑΝΘΙΝΗ. ΤΑ ΣΥΜΠΛΟΚΑ ΑΥΤΑ ΜΕΛΕΤΗΘΗΚΑΝ ΜΕ ΦΑΣΜΑΤΟΣΚΟΠΙΑ ΥΠΕΡΥΘΡΟΥ, ΔΙΑΧΥΤΙΚΗ ΑΝΑΚΛΑΣΗΣ, ΦΘΟΡΙΣΜΟΥ ΠΥΡΗΝΙΚΟΥ ΜΑΓΝΗΤΙΚΟΥ ΣΥΝΤΟΝΙΣΜΟΥ MOSSBAUER ΚΑΙ ΕΓΙΝΑΝ ΜΕΤΡΗΣΕΙΣ ΑΓΩΓΙΜΟΤΗΤΑΣ ΚΑΙ ΜΑΓΝΗΤΙΚΗΣ ΕΠΙΔΕΚΤΙΚΟΤΗΤΑΣ, ΩΣΤΕ ΝΑΒΡΕΘΟΥΝ ΟΙ ΘΕΣΕΙΣ ΣΥΝΔΕΣΗΣ ΤΟΥ ΜΕΤΑΛΛΟΥ ΜΕ ΤΟΝ ΥΠΟΚΑΤΑΣΤΑΤΗ."],"dc:identifier":["10.12681/eadd/0037","http://hdl.handle.net/10442/hedi/0037"],"dc:language":["gre"],"dc:publisher":["National and Kapodistrian University of Athens","Εθνικό και Καποδιστριακό Πανεπιστήμιο Αθηνών (ΕΚΠΑ)"],"dc:subject":["5' ΑΝΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ","6 - Μερκαπτοπουρίνη","8-ΑΖΑΑΔΕΝΙΝΗ","8-ΑΖΑΓΟΥΑΝΙΝΗ","8-ΑΖΑΠΟΥΡΙΝΕΣ","8-ΑΖΑΥΠΟΞΑΝΘΙΝΗ","ΡΙΒΟΣΙΔΙΟ ΤΗΣ 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗΣ","ΣΥΜΠΛΟΚΑ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ","6 - Mercaptopurine","6-MERCAPTOPURINE RIBOSIDE","8-AZAADENINE","8-AZAGUANINE","8-AZAHYPOXANTHINE","8-AZAPURINES","METAL IONS COMPLEXES","Φυσικές Επιστήμες","Χημεία","Natural Sciences","Chemical Sciences"],"dc:title":["ΜΕΛΕΤΗ ΣΥΠΛΟΚΩΝ ΜΕΤΑΛΛΙΚΩΝ ΙΟΝΤΩΝ ΜΕ 5' - ΑΔΕΝΟΣΙΝΟΜΟΝΟΦΩΣΦΟΡΙΚΟ ΟΞΥ, 6-ΜΕΡΚΑΠΤΟΠΟΥΡΙΝΗ ΚΑΙ ΤΟ ΡΙΒΟΣΙΔΙΟ ΤΗΣ ΚΑΙ 8-ΑΖΑΠΟΥΡΙΝΕΣ","STUDY OF METAL IONS COMPLEXES WITH 5'- ADENOSINE MONOPHOSPHATE 6-MERCAPTODURINEAND ITS RIBOSIDE AND 8-AZAPURINES"],"dc:type":["PhD Thesis"]},"updated_at":"2026-07-24T02:25:14Z"}