ΝΕΟΙ ΠΟΤΕΝΣΙΟΜΕΤΡΙΚΟΙ ΑΝΙΧΝΕΥΤΕΣ ΜΕ ΕΦΑΡΜΟΓΕΣ ΣΤΗ ΦΑΡΜΑΚΕΥΤΙΚΗ ΑΝΑΛΥΣΗ

THE PURPOSE OF THIS PH.D. THESIS WAS THE CONSTRUCTION OF SEVEN NEW SELECTIVE ELECTRODES WHICH RESPOND TO THE PHARMACEUTICAL COMPOUNDS SALICILATE, CHLORPROMAZINE, AMITRIPHYLINE, MEPERITINE, PROPANTHELINE, CIMEBILINE AND RANITIDINE. THESTUDY INCLUDED. 1) THE APPLICATION OF THESE ELECTRODES TO PHARMACEUTICAL ANALYSIS (DIRECT POTENTIOMETRY). 2) THE CALCULATION OF THE IONIZATION CONSTANT (KA) OF MEPERIDINE, CIMETIDINE AND RANITIDINE. 3) THE STUDY OF PERMEATION OF CHLORPROMAZINE THROUGH POROUS SYNTHETIC MEMBRANES (IN THE PRESENCE OF DIFFERENT SURFACTANTS) AND THE STUDY OF THE ADSORPTION OF THE SANE DRUG TO ACTIVATED CHARCOAL POTENTIOMETRICALLY. 4) THE APPLICATION OF THE CIMETIDINE AND KEMITIDINE ELECTRODES TO THE ANALYSIS OF THE DRUGS IN SERUM AND URINE AFTER EXTRACTING THEDRUGS WITH COMMERCIALLY AVAILABLE SEP-PAK CARTRIDGES. 5) THE NEWLY CONSTRUCTED ELECTRODES HAVE BEEN USED IN DRUG DISSOLUTION STUDIES. THE COMPLETE SYSTEM WAS BASED ON A TECHNICON CONTINUOUS-FLOW ANALYSER. FOR THIS APPLICATION THE DETECTORS WERE SPECIALLY DESIGNED IN PVC FORM TO BE USED IN CONTINUOUS ANALYSIS AND WERE OF VARIOUS FLOW-THROUGH CONFIGURATION.

Grantor dc:publisher

National and Kapodistrian University of Athens

Year dc:date

1986

Author dc:creator

• Μητσανά-Παπάζογλου, Αναστασία

• ΔΙΑΛΥΤΟΠΟΙΗΣΗ ΦΑΡΜΑΚΩΝ
• ΕΚΛΕΚΤΙΚΑ ΗΛΕΚΤΡΟΔΙΑ ΙΟΝΤΩΝ
• Ποτενσιομετρία
• ΣΥΣΤΗΜΑΤΑ ΣΥΝΕΧΟΥΣ ΡΟΗΣ
• Φαρμακευτική ανάλυση
• CONTINUOUS-FLOW-ANALYSIS
• DRUG DISSOLUTION
• ION-SELECTIVE ELECTRODES
• Pharmaceutical analysis
• Potentiometry
• Φυσικές Επιστήμες
• Χημεία
• Natural Sciences
• Chemical Sciences

Language dc:language

gre

Identifier

10.12681/eadd/0034

OAI identifier oai:identifier

oai:10442/0034