{"id":{"repo_id":"goteborg","oai_identifier":"oai:gupea.ub.gu.se:2077/38467"},"canonical_url":"https://search.dev.ndltd.org/etd/goteborg/oai:gupea.ub.gu.se:2077/38467","repository":{"repo_id":"goteborg","name":"Gothenburg University","base_url":"https://gupea.ub.gu.se/oai/request"},"display":{"title":"Aspects on the management of patients with eosinophilic esophagitis","abstract":"Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. Aims: The overall aim of this thesis was to examine the clinical aspects on the management of patients with EoE. The possibility of a seasonal variation of food bolus impaction in the esophagus, a common complication of EoE patients, was explored. The burden of symptoms and health-related quality of life (HRQL) of patients with EoE at diagnosis, after two months of treatment and at a long-term follow-up point were investigated. The association between the grade of mucosal eosinophilia and the symptoms was studied. Methods & Results: Subjects with bolus impaction (n=314) were included in a retrospective study. A significantly higher incidence of bolus impaction was found in subjects with atopic disorders during the fall (n=90) than during any of the other three seasons (p=0.015). Untreated EoE patients were included in two prospective studies (n=31 and n=47, respectively). Symptoms and HRQL (Watson Dysphagia Scale, EORTC QLQ-OES18, SF-36) were evaluated at diagnosis, after two months of treatment with topical corticosteroids and at least one year after inclusion (median: 23 months after inclusion). The dysphagia-related scores improved after treatment and a partial remission was noted at the long-term follow-up point. The grade of mucosal eosinophilia in untreated patients with dysphagia and esophageal eosinophilia (n=65) was assessed using both hematoxylin-eosin staining and immunohistochemical technique. No correlation was found between the grade of eosinophilia and the symptoms/HRQL using the aforementioned questionnaires, however, a higher grade of eosinophilia was found among patients with concomitant bolus impaction as compared to those without. Conclusions: A seasonal variation was found in the incidence of acute esophageal bolus impaction in patients with atopic disorders. EoE patients had a substantial burden of symptoms, which improved after treatment, and a partial remission was noted more than one year after diagnosis. A high grade of eosinophilia in the proximal part of the esophagus might serve as a marker for an increased risk of bolus impaction.","abstract_html":"Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. Aims: The overall aim of this thesis was to examine the clinical aspects on the management of patients with EoE. The possibility of a seasonal variation of food bolus impaction in the esophagus, a common complication of EoE patients, was explored. The burden of symptoms and health-related quality of life (HRQL) of patients with EoE at diagnosis, after two months of treatment and at a long-term follow-up point were investigated. The association between the grade of mucosal eosinophilia and the symptoms was studied. Methods & Results: Subjects with bolus impaction (n=314) were included in a retrospective study. A significantly higher incidence of bolus impaction was found in subjects with atopic disorders during the fall (n=90) than during any of the other three seasons (p=0.015). Untreated EoE patients were included in two prospective studies (n=31 and n=47, respectively). Symptoms and HRQL (Watson Dysphagia Scale, EORTC QLQ-OES18, SF-36) were evaluated at diagnosis, after two months of treatment with topical corticosteroids and at least one year after inclusion (median: 23 months after inclusion). The dysphagia-related scores improved after treatment and a partial remission was noted at the long-term follow-up point. The grade of mucosal eosinophilia in untreated patients with dysphagia and esophageal eosinophilia (n=65) was assessed using both hematoxylin-eosin staining and immunohistochemical technique. No correlation was found between the grade of eosinophilia and the symptoms/HRQL using the aforementioned questionnaires, however, a higher grade of eosinophilia was found among patients with concomitant bolus impaction as compared to those without. Conclusions: A seasonal variation was found in the incidence of acute esophageal bolus impaction in patients with atopic disorders. EoE patients had a substantial burden of symptoms, which improved after treatment, and a partial remission was noted more than one year after diagnosis. A high grade of eosinophilia in the proximal part of the esophagus might serve as a marker for an increased risk of bolus impaction.","abstract_has_math":false,"creators":["Larsson, Helen"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2015,"date_issued":"2015-05-11","date_published":"2015-05-11","updated_at":"2026-08-21T22:21:56Z","subjects":["eosinophilia","esophagitis","dysphagia","quality of life","bolus impaction"],"languages":["eng"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/2077/38467","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"source_record":{"url":"https://gupea.ub.gu.se/oai/request?verb=GetRecord&metadataPrefix=dim&identifier=oai%3Agupea.ub.gu.se%3A2077%2F38467","prefix":"dim"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Larsson, Helen"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2015-05-11T08:05:08Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2015-05-11T08:05:08Z"]},{"key":"dc:date.issued","label":"Date","values":["2015-05-11"]},{"key":"dc:type","label":"Dc Type","values":["text"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["eosinophilia","esophagitis","dysphagia","quality of life","bolus impaction"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["eng"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/2077/38467"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. Aims: The overall aim of this thesis was to examine the clinical aspects on the management of patients with EoE. The possibility of a seasonal variation of food bolus impaction in the esophagus, a common complication of EoE patients, was explored. The burden of symptoms and health-related quality of life (HRQL) of patients with EoE at diagnosis, after two months of treatment and at a long-term follow-up point were investigated. The association between the grade of mucosal eosinophilia and the symptoms was studied. Methods & Results: Subjects with bolus impaction (n=314) were included in a retrospective study. A significantly higher incidence of bolus impaction was found in subjects with atopic disorders during the fall (n=90) than during any of the other three seasons (p=0.015). Untreated EoE patients were included in two prospective studies (n=31 and n=47, respectively). Symptoms and HRQL (Watson Dysphagia Scale, EORTC QLQ-OES18, SF-36) were evaluated at diagnosis, after two months of treatment with topical corticosteroids and at least one year after inclusion (median: 23 months after inclusion). The dysphagia-related scores improved after treatment and a partial remission was noted at the long-term follow-up point. The grade of mucosal eosinophilia in untreated patients with dysphagia and esophageal eosinophilia (n=65) was assessed using both hematoxylin-eosin staining and immunohistochemical technique. No correlation was found between the grade of eosinophilia and the symptoms/HRQL using the aforementioned questionnaires, however, a higher grade of eosinophilia was found among patients with concomitant bolus impaction as compared to those without. Conclusions: A seasonal variation was found in the incidence of acute esophageal bolus impaction in patients with atopic disorders. EoE patients had a substantial burden of symptoms, which improved after treatment, and a partial remission was noted more than one year after diagnosis. A high grade of eosinophilia in the proximal part of the esophagus might serve as a marker for an increased risk of bolus impaction."]},{"key":"dc:title","label":"Title","values":["Aspects on the management of patients with eosinophilic esophagitis"]}]}],"canonical_facts":{"dc:creator":["Larsson, Helen"],"dc:date.accessioned":["2015-05-11T08:05:08Z"],"dc:date.available":["2015-05-11T08:05:08Z"],"dc:date.issued":["2015-05-11"],"dc:description.abstract":["Eosinophilic esophagitis (EoE) is an inflammatory disorder of the esophagus characterized by symptoms of esophageal dysfunction and eosinophilia in the esophageal mucosa. This condition may affect approximately 1% of the general population and is strongly associated with allergy/atopic diatheses. Aims: The overall aim of this thesis was to examine the clinical aspects on the management of patients with EoE. The possibility of a seasonal variation of food bolus impaction in the esophagus, a common complication of EoE patients, was explored. The burden of symptoms and health-related quality of life (HRQL) of patients with EoE at diagnosis, after two months of treatment and at a long-term follow-up point were investigated. The association between the grade of mucosal eosinophilia and the symptoms was studied. Methods & Results: Subjects with bolus impaction (n=314) were included in a retrospective study. A significantly higher incidence of bolus impaction was found in subjects with atopic disorders during the fall (n=90) than during any of the other three seasons (p=0.015). Untreated EoE patients were included in two prospective studies (n=31 and n=47, respectively). Symptoms and HRQL (Watson Dysphagia Scale, EORTC QLQ-OES18, SF-36) were evaluated at diagnosis, after two months of treatment with topical corticosteroids and at least one year after inclusion (median: 23 months after inclusion). The dysphagia-related scores improved after treatment and a partial remission was noted at the long-term follow-up point. The grade of mucosal eosinophilia in untreated patients with dysphagia and esophageal eosinophilia (n=65) was assessed using both hematoxylin-eosin staining and immunohistochemical technique. No correlation was found between the grade of eosinophilia and the symptoms/HRQL using the aforementioned questionnaires, however, a higher grade of eosinophilia was found among patients with concomitant bolus impaction as compared to those without. Conclusions: A seasonal variation was found in the incidence of acute esophageal bolus impaction in patients with atopic disorders. EoE patients had a substantial burden of symptoms, which improved after treatment, and a partial remission was noted more than one year after diagnosis. A high grade of eosinophilia in the proximal part of the esophagus might serve as a marker for an increased risk of bolus impaction."],"dc:identifier.uri":["http://hdl.handle.net/2077/38467"],"dc:language.iso":["eng"],"dc:subject":["eosinophilia","esophagitis","dysphagia","quality of life","bolus impaction"],"dc:title":["Aspects on the management of patients with eosinophilic esophagitis"],"dc:type":["text"]},"updated_at":"2026-08-21T22:21:56Z"}