{"id":{"repo_id":"gmu","oai_identifier":"oai:MARS:1920/14318"},"canonical_url":"https://search.dev.ndltd.org/etd/gmu/oai:MARS:1920/14318","repository":{"repo_id":"gmu","name":"George Mason University","base_url":"https://mars.gmu.edu/server/oai/request"},"display":{"title":"CONSEQUENCES OF RECREATIONAL MARIJUANA USE ON INFLAMMATORY PATHWAYS IN YOUTH WITH HIV","abstract":"In 2022, nearly one-third of the approximately 32,000 newly diagnosed HIV infections in the United States occurred among youth aged 18 to 25 years. Despite effective viral suppression through combination antiretroviral therapy (ART), youth with HIV still face heightened risks of developing non-AIDS related comorbidities due to chronic inflammation stemming from persistent immune activation. Exploring the potential of marijuana (cannabis) as an immunomodulatory agent has gained attention as a strategy to alleviate chronic inflammation. However, despite a significant portion of youth with HIV using recreational marijuana, its effects on their overall health remain poorly understood.Our study aimed to investigate how recreational marijuana affects inflammatory pathways in youth with HIV. We conducted genome-wide peripheral blood cell transcriptome profiling to examine the effects of recreational marijuana, both alone and in combination with tobacco, in virally suppressed youth with HIV compared to youth without HIV, who used no substance. Additionally, we utilized in-silico cellular deconvolution with machine learning algorithm to analyze immune cell-specific genes and pathways. We found that youth with HIV displayed unique transcriptome bioprofile influenced by viral suppression and substance use. When compared to youth without HIV, marijuana use alone normalized the expression of inflammation-related genes and pathways, indicating an anti-inflammatory effect. However, when marijuana was used with tobacco, it resulted in a distinct pro-inflammatory profile. Our findings provide valuable insights into the practical use of recreational marijuana among youth with HIV. With the increasing legalization of both recreational and medical marijuana across multiple states, our study offers crucial evidence-based assessments of the effects of marijuana on people with HIV, particularly regarding its impact on inflammatory pathways.","abstract_html":"In 2022, nearly one-third of the approximately 32,000 newly diagnosed HIV infections in the United States occurred among youth aged 18 to 25 years. Despite effective viral suppression through combination antiretroviral therapy (ART), youth with HIV still face heightened risks of developing non-AIDS related comorbidities due to chronic inflammation stemming from persistent immune activation. Exploring the potential of marijuana (cannabis) as an immunomodulatory agent has gained attention as a strategy to alleviate chronic inflammation. However, despite a significant portion of youth with HIV using recreational marijuana, its effects on their overall health remain poorly understood.Our study aimed to investigate how recreational marijuana affects inflammatory pathways in youth with HIV. We conducted genome-wide peripheral blood cell transcriptome profiling to examine the effects of recreational marijuana, both alone and in combination with tobacco, in virally suppressed youth with HIV compared to youth without HIV, who used no substance. Additionally, we utilized in-silico cellular deconvolution with machine learning algorithm to analyze immune cell-specific genes and pathways. We found that youth with HIV displayed unique transcriptome bioprofile influenced by viral suppression and substance use. When compared to youth without HIV, marijuana use alone normalized the expression of inflammation-related genes and pathways, indicating an anti-inflammatory effect. However, when marijuana was used with tobacco, it resulted in a distinct pro-inflammatory profile. Our findings provide valuable insights into the practical use of recreational marijuana among youth with HIV. With the increasing legalization of both recreational and medical marijuana across multiple states, our study offers crucial evidence-based assessments of the effects of marijuana on people with HIV, particularly regarding its impact on inflammatory pathways.","abstract_has_math":false,"creators":["Borkar, Samiksha Amit"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024","date_published":"2024","updated_at":"2026-07-27T19:51:50Z","subjects":["Bioprofiles","HIV suppression","Inflammation","Marijuana","Transcriptome","Youth with HIV"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:1920/14318"],"render_values":[{"text":"hdl:1920/14318","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.issued","label":"Date","values":["2024"]},{"key":"dc:type","label":"Dc Type","values":["Dissertation"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Bioprofiles","HIV suppression","Inflammation","Marijuana","Transcriptome","Youth with HIV"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["hdl:1920/14318"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.other","label":"Dc Description Other","values":["In 2022, nearly one-third of the approximately 32,000 newly diagnosed HIV infections in the United States occurred among youth aged 18 to 25 years. Despite effective viral suppression through combination antiretroviral therapy (ART), youth with HIV still face heightened risks of developing non-AIDS related comorbidities due to chronic inflammation stemming from persistent immune activation. Exploring the potential of marijuana (cannabis) as an immunomodulatory agent has gained attention as a strategy to alleviate chronic inflammation. However, despite a significant portion of youth with HIV using recreational marijuana, its effects on their overall health remain poorly understood.Our study aimed to investigate how recreational marijuana affects inflammatory pathways in youth with HIV. We conducted genome-wide peripheral blood cell transcriptome profiling to examine the effects of recreational marijuana, both alone and in combination with tobacco, in virally suppressed youth with HIV compared to youth without HIV, who used no substance. Additionally, we utilized in-silico cellular deconvolution with machine learning algorithm to analyze immune cell-specific genes and pathways. We found that youth with HIV displayed unique transcriptome bioprofile influenced by viral suppression and substance use. When compared to youth without HIV, marijuana use alone normalized the expression of inflammation-related genes and pathways, indicating an anti-inflammatory effect. However, when marijuana was used with tobacco, it resulted in a distinct pro-inflammatory profile. Our findings provide valuable insights into the practical use of recreational marijuana among youth with HIV. With the increasing legalization of both recreational and medical marijuana across multiple states, our study offers crucial evidence-based assessments of the effects of marijuana on people with HIV, particularly regarding its impact on inflammatory pathways."]},{"key":"dc:title","label":"Title","values":["CONSEQUENCES OF RECREATIONAL MARIJUANA USE ON INFLAMMATORY PATHWAYS IN YOUTH WITH HIV"]}]}],"canonical_facts":{"dc:date.issued":["2024"],"dc:description.other":["In 2022, nearly one-third of the approximately 32,000 newly diagnosed HIV infections in the United States occurred among youth aged 18 to 25 years. Despite effective viral suppression through combination antiretroviral therapy (ART), youth with HIV still face heightened risks of developing non-AIDS related comorbidities due to chronic inflammation stemming from persistent immune activation. Exploring the potential of marijuana (cannabis) as an immunomodulatory agent has gained attention as a strategy to alleviate chronic inflammation. However, despite a significant portion of youth with HIV using recreational marijuana, its effects on their overall health remain poorly understood.Our study aimed to investigate how recreational marijuana affects inflammatory pathways in youth with HIV. We conducted genome-wide peripheral blood cell transcriptome profiling to examine the effects of recreational marijuana, both alone and in combination with tobacco, in virally suppressed youth with HIV compared to youth without HIV, who used no substance. Additionally, we utilized in-silico cellular deconvolution with machine learning algorithm to analyze immune cell-specific genes and pathways. We found that youth with HIV displayed unique transcriptome bioprofile influenced by viral suppression and substance use. When compared to youth without HIV, marijuana use alone normalized the expression of inflammation-related genes and pathways, indicating an anti-inflammatory effect. However, when marijuana was used with tobacco, it resulted in a distinct pro-inflammatory profile. Our findings provide valuable insights into the practical use of recreational marijuana among youth with HIV. With the increasing legalization of both recreational and medical marijuana across multiple states, our study offers crucial evidence-based assessments of the effects of marijuana on people with HIV, particularly regarding its impact on inflammatory pathways."],"dc:identifier":["hdl:1920/14318"],"dc:subject":["Bioprofiles","HIV suppression","Inflammation","Marijuana","Transcriptome","Youth with HIV"],"dc:title":["CONSEQUENCES OF RECREATIONAL MARIJUANA USE ON INFLAMMATORY PATHWAYS IN YOUTH WITH HIV"],"dc:type":["Dissertation"]},"updated_at":"2026-07-27T19:51:50Z"}