Abstract
dc:description.abstractBiological agents, including peptides and gene delivery systems (recombinant adenoviral vectors), suffer from a relative lack of native targeting capacity. Improvement of their targeting capacity could significantly increase the efficiency of these agents to provide therapeutic effects. Selective targeting of an anti-oxidant peptide to the vasculature in the SHRSP and administration of a variety of adenovirus (Ad) 35-based vectors into transgenic mice has lead to a significant enhancement in both the effectiveness of the anti-oxidant treatment and increased understanding of the requirements needed for the generation of a successfully targeted Ad35 vector. This helps understanding of the requirements for a successful treatment for cardiovascular disease and cancer.
Degree
thesis:*- Level dc:type.qualificationlevel
- PhD
- Grantor dc:publisher.institution
- University of Glasgow
- Year dc:date.issued
- 2009
Author and committee
dc:creator, dc:contributor.*- Author dc:creator
-
- Greig, Jenny A.
Subjects
dc:subject × 1Rights
- Language dc:language
- en