Development of porous delivery systems for oral drug and vaccine administration

As porous materials (polymers, metals and ceramics) have many interesting physical and chemical properties, they have widespread applications in nearly every technology sector. Chapter 1 described the main biomedical application of cellular materials: the use of porous ceramics, polymers and/or metals as bone implants for structural purposes as well as for local drug delivery. Several manufacturing techniques for porous ceramics are reviewed and the drug release from these porous devices is described. Chapter 1 also summarizes the most important aspects of the manufacturing and formulation of conventional tablets and pellets since the overall aim of this research project was to evaluate the possible applications of porous tablets and pellets for oral drug delivery. More specifically the application of porous tablets for the manufacturing of tablets containing low-dosed drugs or drugs with limited compression properties were investigated as well as the possibilities offered by porous pellets for oral delivery of conventional drugs as well as vaccines.

Author dc:creator

• Cosijns, An

Contributors dc:contributor

• Remon, Jean Paul
• Vervaet, Chris

• Medicine and Health Sciences
• porous tablets
• porous pellets
• low-dosed drugs
• in vitro and in vivo behaviour
• oral vaccination

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://biblio.ugent.be/publication/518408
https://biblio.ugent.be/publication/518408/file/4334938

OAI identifier oai:identifier

oai:archive.ugent.be:518408