Psycho-endocrinological aspects in aging males and transsexual persons
type: CreativeWork
description: Studies on the relationship between behaviour and sex steroids do not always provide consistent results. The aim of this thesis is to contribute to the clarification of certain endocrinological and psychoendocrinological aspects in two different clinical contexts. More subtle changes in androgen levels in aging males and profound cross-sex hormone administration treatment in transsexual individuals have been considered. Chapter 2 focused on the effects of (inhibiting) oestradiol feedback on gonadotropin and testosterone secretion in young versus elderly men. The hypothesis is tested that decreased T in aging men might result from increased E2 negative feedback. The aim of the study in Chapter 3 was to correlate clinical symptoms tentatively described as ‘andropause’ with biochemical measures of androgen status; the usefulness of questionnaires to detect hypoandrogenism in the elderly being dependent on their ability to predict (subnormal) androgen levels. In the same cohort of elderly men we wished to determine the prevalence of depression as assessed by a 30- item Geriatric Depression Scale (GDS) score and to describe the association between this score and sex steroids, an androgen receptor polymorphism and general health related quality of life and functionality (Chapter 4). In Chapter 5 and 6, we no longer evaluated relative sex hormone deficiencies, but described the effects of drastic induction of overt hypogonadism followed by cross-sex hormonal substitution in transsexual persons.In the first study (Chapter 5) the regulatory role of oestrogens and androgens on haemoglobin and the haematocrit in transsexual persons undergoing cross hormone administration was monitored. To this aim, we assessed a quantitative assay of bone marrow erythropoietic activity, the soluble transferrin receptor. Since the start of treating transsexual persons in the multidisciplinary Ghent Gender Team it has been decided to advise a dual-phase hormonal schedule, with a first reversible…
abstract: Studies on the relationship between behaviour and sex steroids do not always provide consistent results. The aim of this thesis is to contribute to the clarification of certain endocrinological and psychoendocrinological aspects in two different clinical contexts. More subtle changes in androgen levels in aging males and profound cross-sex hormone administration treatment in transsexual individuals have been considered. Chapter 2 focused on the effects of (inhibiting) oestradiol feedback on gonadotropin and testosterone secretion in young versus elderly men. The hypothesis is tested that decreased T in aging men might result from increased E2 negative feedback. The aim of the study in Chapter 3 was to correlate clinical symptoms tentatively described as ‘andropause’ with biochemical measures of androgen status; the usefulness of questionnaires to detect hypoandrogenism in the elderly being dependent on their ability to predict (subnormal) androgen levels. In the same cohort of elderly men we wished to determine the prevalence of depression as assessed by a 30- item Geriatric Depression Scale (GDS) score and to describe the association between this score and sex steroids, an androgen receptor polymorphism and general health related quality of life and functionality (Chapter 4). In Chapter 5 and 6, we no longer evaluated relative sex hormone deficiencies, but described the effects of drastic induction of overt hypogonadism followed by cross-sex hormonal substitution in transsexual persons.In the first study (Chapter 5) the regulatory role of oestrogens and androgens on haemoglobin and the haematocrit in transsexual persons undergoing cross hormone administration was monitored. To this aim, we assessed a quantitative assay of bone marrow erythropoietic activity, the soluble transferrin receptor. Since the start of treating transsexual persons in the multidisciplinary Ghent Gender Team it has been decided to advise a dual-phase hormonal schedule, with a first reversible…
author: T'Sjoen, G
language: und
date published: 2006
date modified: 2026-07-24T02:23:03Z
provider: Ghent University
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: Ghent University

PropertyValue
property ID: Handle
value: http://hdl.handle.net/1854/LU-468795