Effect of viral and host genetics on pcv2 replication in lymphoblasts and clearance by monocytes

Porcine circovirus type 2 (PCV2), a very small, circular, single-stranded DNA virus, is the major etiologic agent of porcine circovirus-associated diseases (PCVADs) and is widely prevalent in swine herds. It causes significant economic losses to the global pig industry. Three major PCV2 genotypes (PCV2a, PCV2b and PCV2d) have been identified around the world. Among the PCVADs, the most prominent disease associated with PCV2 is post-weaning multisystemic wasting syndrome (PMWS). PMWS severity varies by host breed; notably, Landrace and Large White pigs exhibit more severe clinical manifestations than Piétrain pigs. Pathologic features of PMWS in wasted pigs include elevated viral loads, progressive lymphocyte depletion, and monocyte infiltration in the lymph nodes, which critically impairs the immune system and often leads to fatal outcomes.

Grantor dc:publisher

Ghent University. Faculty of Veterinary Medicine

Year dc:date

2023

Author dc:creator

• Ouyang, Yueling

Contributors dc:contributor

• Nauwynck, Hans

• Veterinary Sciences

Statement dc:rights

• info:eu-repo/semantics/openAccess

Language dc:language

eng

Identifier

https://biblio.ugent.be/publication/01HJ0MHCW2PASCSNTDJ32WEHHX
https://biblio.ugent.be/publication/01HJ0MHCW2PASCSNTDJ32WEHHX/file/01HJ0MS7244RZT9TGN23T5QDHT

OAI identifier oai:identifier

oai:archive.ugent.be:01HJ0MHCW2PASCSNTDJ32WEHHX