{"id":{"repo_id":"gatech","oai_identifier":"oai:repository.gatech.edu:1853/81513"},"canonical_url":"https://search.dev.ndltd.org/etd/gatech/oai:repository.gatech.edu:1853/81513","repository":{"repo_id":"gatech","name":"Georgia Tech","base_url":"https://repository.gatech.edu/server/oai/request"},"display":{"title":"Cycled Pulsing for Prostate Tumor to Mitigate Thermal Damage, While Conserving the Ablation Area","abstract":"Prostate cancer is one of the most common cancer-related diseases among men. Traditional treatment options cannot always treat the disease successfully as limitations and complications exist since the traditional treatments lack specificity and have an invasive nature. Focal therapy is a prominent option to address the existing problem, since it is minimally invasive and target specific region of the tumor. Most focal therapy techniques are thermally mediated, which can cause damage to the surrounding tissue, vasculatures, and nerves. Irreversible electroporation is a minimally thermal technique which delivers electric pulses to create transient nanopores in cell membrane, ultimately leading to cell death. IRE is predominantly non-thermal technique, but the thermal side effect of Joule heating exists during treatment. Cycled pulsing of IRE is a technique to mitigate thermal damage through partitioning of pulses and adding interpulse delays. The purpose of this thesis was to investigate the effects of segmenting the pulses and adding delays to regular IRE pulse schemes on the temperature fluctuation and therapeutic efficacy. The partitioning of pulses and interpulse delays decreased the temperature rise during the IRE treatment, while the ablation areas of the experimental groups were maintained in close range to the control group. The lethal electric field threshold did not increase with the variables. Therefore, segmenting the pulses and adding the delays were effective at dissipating thermal damage, while maintaining the therapeutic efficacy.","abstract_html":"Prostate cancer is one of the most common cancer-related diseases among men. Traditional treatment options cannot always treat the disease successfully as limitations and complications exist since the traditional treatments lack specificity and have an invasive nature. Focal therapy is a prominent option to address the existing problem, since it is minimally invasive and target specific region of the tumor. Most focal therapy techniques are thermally mediated, which can cause damage to the surrounding tissue, vasculatures, and nerves. Irreversible electroporation is a minimally thermal technique which delivers electric pulses to create transient nanopores in cell membrane, ultimately leading to cell death. IRE is predominantly non-thermal technique, but the thermal side effect of Joule heating exists during treatment. Cycled pulsing of IRE is a technique to mitigate thermal damage through partitioning of pulses and adding interpulse delays. The purpose of this thesis was to investigate the effects of segmenting the pulses and adding delays to regular IRE pulse schemes on the temperature fluctuation and therapeutic efficacy. The partitioning of pulses and interpulse delays decreased the temperature rise during the IRE treatment, while the ablation areas of the experimental groups were maintained in close range to the control group. The lethal electric field threshold did not increase with the variables. Therefore, segmenting the pulses and adding the delays were effective at dissipating thermal damage, while maintaining the therapeutic efficacy.","abstract_has_math":false,"creators":["Shin, Hee Chang"],"institution":"Georgia Institute of Technology","degree_name":null,"degree_level":"Masters","degree_discipline":null,"degree_department":"Biomedical Engineering (Joint GT/Emory Department)","school":null,"contributors":[],"advisors":["Davalos, Rafael V."],"committee_chairs":[],"committee_members":["Prausnitz, Mark","Sarkar, Aniruddh"],"year":2025,"date_issued":"2025-04-23","date_published":"2025-04-23","updated_at":"2026-07-27T19:49:22Z","subjects":["IRE","Cycled Pulsing","Delay"],"languages":["en_US"],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://hdl.handle.net/1853/81513","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor.advisor","label":"Advisor","values":["Davalos, Rafael V."]},{"key":"dc:contributor.committeemember","label":"Committee Member","values":["Prausnitz, Mark","Sarkar, Aniruddh"]},{"key":"dc:contributor.department","label":"Department","values":["Biomedical Engineering (Joint GT/Emory Department)"]},{"key":"dc:creator","label":"Author","values":["Shin, Hee Chang"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2026-05-21T20:39:47Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2026-05-21T20:39:47Z"]},{"key":"dc:date.issued","label":"Date","values":["2025-04-23"]},{"key":"dc:publisher","label":"Institution","values":["Georgia Institute of Technology"]},{"key":"dc:type","label":"Dc Type","values":["Text"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Masters"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["IRE","Cycled Pulsing","Delay"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language.iso","label":"Language (ISO)","values":["en_US"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["https://hdl.handle.net/1853/81513"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Prostate cancer is one of the most common cancer-related diseases among men. Traditional treatment options cannot always treat the disease successfully as limitations and complications exist since the traditional treatments lack specificity and have an invasive nature. Focal therapy is a prominent option to address the existing problem, since it is minimally invasive and target specific region of the tumor. Most focal therapy techniques are thermally mediated, which can cause damage to the surrounding tissue, vasculatures, and nerves. Irreversible electroporation is a minimally thermal technique which delivers electric pulses to create transient nanopores in cell membrane, ultimately leading to cell death. IRE is predominantly non-thermal technique, but the thermal side effect of Joule heating exists during treatment. Cycled pulsing of IRE is a technique to mitigate thermal damage through partitioning of pulses and adding interpulse delays. The purpose of this thesis was to investigate the effects of segmenting the pulses and adding delays to regular IRE pulse schemes on the temperature fluctuation and therapeutic efficacy. The partitioning of pulses and interpulse delays decreased the temperature rise during the IRE treatment, while the ablation areas of the experimental groups were maintained in close range to the control group. The lethal electric field threshold did not increase with the variables. Therefore, segmenting the pulses and adding the delays were effective at dissipating thermal damage, while maintaining the therapeutic efficacy."]},{"key":"dc:description.degree","label":"Dc Description Degree","values":["M.S."]},{"key":"dc:format.mimetype","label":"Dc Format Mimetype","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Cycled Pulsing for Prostate Tumor to Mitigate Thermal Damage, While Conserving the Ablation Area"]}]}],"canonical_facts":{"dc:contributor.advisor":["Davalos, Rafael V."],"dc:contributor.committeemember":["Prausnitz, Mark","Sarkar, Aniruddh"],"dc:contributor.department":["Biomedical Engineering (Joint GT/Emory Department)"],"dc:creator":["Shin, Hee Chang"],"dc:date.accessioned":["2026-05-21T20:39:47Z"],"dc:date.available":["2026-05-21T20:39:47Z"],"dc:date.issued":["2025-04-23"],"dc:description.abstract":["Prostate cancer is one of the most common cancer-related diseases among men. Traditional treatment options cannot always treat the disease successfully as limitations and complications exist since the traditional treatments lack specificity and have an invasive nature. Focal therapy is a prominent option to address the existing problem, since it is minimally invasive and target specific region of the tumor. Most focal therapy techniques are thermally mediated, which can cause damage to the surrounding tissue, vasculatures, and nerves. Irreversible electroporation is a minimally thermal technique which delivers electric pulses to create transient nanopores in cell membrane, ultimately leading to cell death. IRE is predominantly non-thermal technique, but the thermal side effect of Joule heating exists during treatment. Cycled pulsing of IRE is a technique to mitigate thermal damage through partitioning of pulses and adding interpulse delays. The purpose of this thesis was to investigate the effects of segmenting the pulses and adding delays to regular IRE pulse schemes on the temperature fluctuation and therapeutic efficacy. The partitioning of pulses and interpulse delays decreased the temperature rise during the IRE treatment, while the ablation areas of the experimental groups were maintained in close range to the control group. The lethal electric field threshold did not increase with the variables. Therefore, segmenting the pulses and adding the delays were effective at dissipating thermal damage, while maintaining the therapeutic efficacy."],"dc:description.degree":["M.S."],"dc:format.mimetype":["application/pdf"],"dc:identifier.uri":["https://hdl.handle.net/1853/81513"],"dc:language.iso":["en_US"],"dc:publisher":["Georgia Institute of Technology"],"dc:subject":["IRE","Cycled Pulsing","Delay"],"dc:title":["Cycled Pulsing for Prostate Tumor to Mitigate Thermal Damage, While Conserving the Ablation Area"],"dc:type":["Text"],"thesis:degree_level":["Masters"]},"updated_at":"2026-07-27T19:49:22Z"}