{"id":{"repo_id":"fsu-retro","oai_identifier":"oai:diginole.lib.fsu.edu:fsu_927960"},"canonical_url":"https://search.dev.ndltd.org/etd/fsu-retro/oai:diginole.lib.fsu.edu:fsu_927960","repository":{"repo_id":"fsu-retro","name":"Florida State University","base_url":"https://repository.lib.fsu.edu/oai2"},"display":{"title":"Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle","abstract":"Older adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize glucocorticoid myopathic features in aged muscle. The objectives of this study were to define the extent to which sex influences the development of glucocorticoid myopathy in aged muscle, and to determine the extent to which moderate intensity aerobic exercise training protects against development of myopathy. 24-month-old female (n=30) and male (n=33) mice were randomized to either sedentary or aerobic exercise groups. Within their respective groups, mice were randomized to either daily treatment with injections of dexamethasone (DEX) or saline. Following treatments, the contractile properties of the triceps surae complex were assessed in situ. DEX marginally lowered muscle mass and soluble protein content in both sexes, which was attenuated by aerobic exercise only in females. DEX-treated females expressed greater sub-tetanic contractile properties in a sex-specific manner, which were not influenced by aerobic exercise. DEX increased muscle fatigue in both sexes, but aerobic exercise prevented the fatigue induction only in females. The sex-specific differences to muscle function in response to DEX treatment coincided with sex-specific changes to the contents of protein related to calcium handling, mitochondrial quality control, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the capacity of short-term aerobic exercise to protect against those changes.","abstract_html":"Older adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize glucocorticoid myopathic features in aged muscle. The objectives of this study were to define the extent to which sex influences the development of glucocorticoid myopathy in aged muscle, and to determine the extent to which moderate intensity aerobic exercise training protects against development of myopathy. 24-month-old female (n=30) and male (n=33) mice were randomized to either sedentary or aerobic exercise groups. Within their respective groups, mice were randomized to either daily treatment with injections of dexamethasone (DEX) or saline. Following treatments, the contractile properties of the triceps surae complex were assessed in situ. DEX marginally lowered muscle mass and soluble protein content in both sexes, which was attenuated by aerobic exercise only in females. DEX-treated females expressed greater sub-tetanic contractile properties in a sex-specific manner, which were not influenced by aerobic exercise. DEX increased muscle fatigue in both sexes, but aerobic exercise prevented the fatigue induction only in females. The sex-specific differences to muscle function in response to DEX treatment coincided with sex-specific changes to the contents of protein related to calcium handling, mitochondrial quality control, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the capacity of short-term aerobic exercise to protect against those changes.","abstract_has_math":false,"creators":[],"institution":"Florida State University","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Laskin, Grant R. (author)","Gordon, Bradley S. (professor directing dissertation)","Chase, P. Bryant (university representative)","Hwang, Hyun Seok (committee member)","Solis, Christopher (committee member)","Florida State University (degree granting institution)","College of Education, Health, and Human Sciences (degree granting college)","Department of Health, Nutrition, and Food Sciences (degree granting department)"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2024,"date_issued":"2024","date_published":"2024","updated_at":"2026-07-27T19:47:52Z","subjects":["Physiology"],"languages":["English"],"rights":[],"rights_urls":[],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["fsu:927960","iid: Laskin_fsu_0071E_18506"],"render_values":[{"text":"fsu:927960","href":null,"code":true},{"text":"iid: Laskin_fsu_0071E_18506","href":null,"code":true}]}]},"links":{"outbound_url":null,"outbound_label":null,"outbound_source":null},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Laskin, Grant R. 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Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize glucocorticoid myopathic features in aged muscle. The objectives of this study were to define the extent to which sex influences the development of glucocorticoid myopathy in aged muscle, and to determine the extent to which moderate intensity aerobic exercise training protects against development of myopathy. 24-month-old female (n=30) and male (n=33) mice were randomized to either sedentary or aerobic exercise groups. Within their respective groups, mice were randomized to either daily treatment with injections of dexamethasone (DEX) or saline. Following treatments, the contractile properties of the triceps surae complex were assessed in situ. DEX marginally lowered muscle mass and soluble protein content in both sexes, which was attenuated by aerobic exercise only in females. DEX-treated females expressed greater sub-tetanic contractile properties in a sex-specific manner, which were not influenced by aerobic exercise. DEX increased muscle fatigue in both sexes, but aerobic exercise prevented the fatigue induction only in females. The sex-specific differences to muscle function in response to DEX treatment coincided with sex-specific changes to the contents of protein related to calcium handling, mitochondrial quality control, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the capacity of short-term aerobic exercise to protect against those changes.","A Dissertation submitted to the Department of Health, Nutrition, and Food Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy.","February 26, 2024.","Includes bibliographical references.","Bradley S. Gordon, Professor Directing Dissertation; P. Bryant Chase, University Representative; Hyun Seok Hwang, Committee Member; Christopher Solis, Committee Member."]},{"key":"dc:format","label":"Dc Format","values":["computer","online resource","1 online resource (118 pages)","application/pdf"]},{"key":"dc:title","label":"Title","values":["Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle"]}]}],"canonical_facts":{"dc:contributor":["Laskin, Grant R. (author)","Gordon, Bradley S. (professor directing dissertation)","Chase, P. Bryant (university representative)","Hwang, Hyun Seok (committee member)","Solis, Christopher (committee member)","Florida State University (degree granting institution)","College of Education, Health, and Human Sciences (degree granting college)","Department of Health, Nutrition, and Food Sciences (degree granting department)"],"dc:date":["2024"],"dc:description":["Older adults are vulnerable to glucocorticoid-induced muscle atrophy and weakness, with sex potentially influencing susceptibility to those effects. Aerobic exercise can reduce glucocorticoid-induced muscle atrophy in young rodents. However, it is unknown whether aerobic exercise can antagonize glucocorticoid myopathic features in aged muscle. The objectives of this study were to define the extent to which sex influences the development of glucocorticoid myopathy in aged muscle, and to determine the extent to which moderate intensity aerobic exercise training protects against development of myopathy. 24-month-old female (n=30) and male (n=33) mice were randomized to either sedentary or aerobic exercise groups. Within their respective groups, mice were randomized to either daily treatment with injections of dexamethasone (DEX) or saline. Following treatments, the contractile properties of the triceps surae complex were assessed in situ. DEX marginally lowered muscle mass and soluble protein content in both sexes, which was attenuated by aerobic exercise only in females. DEX-treated females expressed greater sub-tetanic contractile properties in a sex-specific manner, which were not influenced by aerobic exercise. DEX increased muscle fatigue in both sexes, but aerobic exercise prevented the fatigue induction only in females. The sex-specific differences to muscle function in response to DEX treatment coincided with sex-specific changes to the contents of protein related to calcium handling, mitochondrial quality control, and glucocorticoid receptor in muscle. These findings define several important sexually dimorphic changes to aged skeletal muscle physiology in response to glucocorticoid treatment and define the capacity of short-term aerobic exercise to protect against those changes.","A Dissertation submitted to the Department of Health, Nutrition, and Food Sciences in partial fulfillment of the requirements for the degree of Doctor of Philosophy.","February 26, 2024.","Includes bibliographical references.","Bradley S. Gordon, Professor Directing Dissertation; P. Bryant Chase, University Representative; Hyun Seok Hwang, Committee Member; Christopher Solis, Committee Member."],"dc:format":["computer","online resource","1 online resource (118 pages)","application/pdf"],"dc:identifier":["fsu:927960","iid: Laskin_fsu_0071E_18506"],"dc:language":["English"],"dc:publisher":["Florida State University"],"dc:subject":["Physiology"],"dc:title":["Aerobic Exercise-Mediated Prevention Against Glucocorticoid Myopathy in Aged Skeletal Muscle"],"dc:type":["Text","doctoral thesis"]},"updated_at":"2026-07-27T19:47:52Z"}