{"id":{"repo_id":"freiburg-diss","oai_identifier":"oai:freidok.uni-freiburg.de:816"},"canonical_url":"https://search.dev.ndltd.org/etd/freiburg-diss/oai:freidok.uni-freiburg.de:816","repository":{"repo_id":"freiburg-diss","name":"University of Freiburg","base_url":"https://freidok.uni-freiburg.de/oai/oai2.php"},"display":{"title":"Hyporesponsive synovial fluid T cells in rheumatoid Arthritis","abstract":"Rheumatoid arthritis is a chronic, usually progressive inflammatory disorder of joints in which the immune system plays a central role in pathogenesis. Both chronically inflamed synovial tissue and synovial fluid (SF) are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic T cells (CTL). Only T cells isolated from the SF of many RA patients were anergic upon their activation in vitro by stimulation of the T cell receptor and the co-stimulatory receptor CD28 which means that these T cells did not proliferate. In vitro-activated anergic SF T cells from RA patients were able to express most activation-dependent genes (e.g. CD69, CD25, CD152, IL-13 and IFN-g), although T cells did not proliferate. The main cause for the impaired proliferation of RA SF T cells is the absent expression of T cell growth factor IL-2. The detailed analysis of the hyporesponsive state of RA SF T cells and comparison with other models of T cell anergy (clonal anergy and peripheral tolerance), T cell suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which is present in the synovial fluid of RA patients that contained anergic SF T cells. The identity, origin and function of the proposed factor still has to be determined. Furthermore, T cells from the synovial fluid of RA patients are also hyporesponsive to induction of CD95L/CD95-mediated apoptosis, although they express the death receptor CD95. The determination of different SF T cell phenotypes based on their differential expression of chemokine receptors CCR7 and CXCR6 (Bonzo), the recently described marker for replicative senescence KLRG1 and the effector/memory marker CD45RO revealed that the populations of T cells present in the SF from arthritis patients with anergic and normally proliferating T lymphocytes are similar in seize and composition.","abstract_html":"Rheumatoid arthritis is a chronic, usually progressive inflammatory disorder of joints in which the immune system plays a central role in pathogenesis. Both chronically inflamed synovial tissue and synovial fluid (SF) are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic T cells (CTL). Only T cells isolated from the SF of many RA patients were anergic upon their activation in vitro by stimulation of the T cell receptor and the co-stimulatory receptor CD28 which means that these T cells did not proliferate. In vitro-activated anergic SF T cells from RA patients were able to express most activation-dependent genes (e.g. CD69, CD25, CD152, IL-13 and IFN-g), although T cells did not proliferate. The main cause for the impaired proliferation of RA SF T cells is the absent expression of T cell growth factor IL-2. The detailed analysis of the hyporesponsive state of RA SF T cells and comparison with other models of T cell anergy (clonal anergy and peripheral tolerance), T cell suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which is present in the synovial fluid of RA patients that contained anergic SF T cells. The identity, origin and function of the proposed factor still has to be determined. Furthermore, T cells from the synovial fluid of RA patients are also hyporesponsive to induction of CD95L/CD95-mediated apoptosis, although they express the death receptor CD95. The determination of different SF T cell phenotypes based on their differential expression of chemokine receptors CCR7 and CXCR6 (Bonzo), the recently described marker for replicative senescence KLRG1 and the effector/memory marker CD45RO revealed that the populations of T cells present in the SF from arthritis patients with anergic and normally proliferating T lymphocytes are similar in seize and composition.","abstract_has_math":false,"creators":["Barth, Jan Thomas"],"institution":null,"degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Eibel, Hermann"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":null,"date_issued":"","date_published":null,"updated_at":"2026-07-24T02:21:58Z","subjects":["Anergie"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://freidok.uni-freiburg.de/data/816","outbound_label":"Repository record","outbound_source":"source_url"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Eibel, Hermann"]},{"key":"dc:creator","label":"Author","values":["Barth, Jan Thomas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:type","label":"Dc Type","values":["DoctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Anergie"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Rheumatoid arthritis is a chronic, usually progressive inflammatory disorder of joints in which the immune system plays a central role in pathogenesis. Both chronically inflamed synovial tissue and synovial fluid (SF) are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic T cells (CTL). Only T cells isolated from the SF of many RA patients were anergic upon their activation in vitro by stimulation of the T cell receptor and the co-stimulatory receptor CD28 which means that these T cells did not proliferate. In vitro-activated anergic SF T cells from RA patients were able to express most activation-dependent genes (e.g. CD69, CD25, CD152, IL-13 and IFN-g), although T cells did not proliferate. The main cause for the impaired proliferation of RA SF T cells is the absent expression of T cell growth factor IL-2. The detailed analysis of the hyporesponsive state of RA SF T cells and comparison with other models of T cell anergy (clonal anergy and peripheral tolerance), T cell suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which is present in the synovial fluid of RA patients that contained anergic SF T cells. The identity, origin and function of the proposed factor still has to be determined. Furthermore, T cells from the synovial fluid of RA patients are also hyporesponsive to induction of CD95L/CD95-mediated apoptosis, although they express the death receptor CD95. The determination of different SF T cell phenotypes based on their differential expression of chemokine receptors CCR7 and CXCR6 (Bonzo), the recently described marker for replicative senescence KLRG1 and the effector/memory marker CD45RO revealed that the populations of T cells present in the SF from arthritis patients with anergic and normally proliferating T lymphocytes are similar in seize and composition."]},{"key":"dc:format.medium","label":"Dc Format Medium","values":["application/pdf"]},{"key":"dc:title","label":"Title","values":["Hyporesponsive synovial fluid T cells in rheumatoid Arthritis","Anerge Synovialflüssigkeits-T-Zellen in Rheumatoider Arthritis"]}]}],"canonical_facts":{"dc:contributor":["Eibel, Hermann"],"dc:creator":["Barth, Jan Thomas"],"dc:description.abstract":["Rheumatoid arthritis is a chronic, usually progressive inflammatory disorder of joints in which the immune system plays a central role in pathogenesis. Both chronically inflamed synovial tissue and synovial fluid (SF) are usually rich in infiltrated CD4+ T helper cells (TH cells) and CD8+ cytotoxic T cells (CTL). Only T cells isolated from the SF of many RA patients were anergic upon their activation in vitro by stimulation of the T cell receptor and the co-stimulatory receptor CD28 which means that these T cells did not proliferate. In vitro-activated anergic SF T cells from RA patients were able to express most activation-dependent genes (e.g. CD69, CD25, CD152, IL-13 and IFN-g), although T cells did not proliferate. The main cause for the impaired proliferation of RA SF T cells is the absent expression of T cell growth factor IL-2. The detailed analysis of the hyporesponsive state of RA SF T cells and comparison with other models of T cell anergy (clonal anergy and peripheral tolerance), T cell suppressions (TR1 cells and CD25+ TS cells) and replicative senescent T cells suggested that this kind of T cell hyporesponsiveness is different. T cell hyporesponsiveness is obviously induced by a soluble factor, which is present in the synovial fluid of RA patients that contained anergic SF T cells. The identity, origin and function of the proposed factor still has to be determined. Furthermore, T cells from the synovial fluid of RA patients are also hyporesponsive to induction of CD95L/CD95-mediated apoptosis, although they express the death receptor CD95. The determination of different SF T cell phenotypes based on their differential expression of chemokine receptors CCR7 and CXCR6 (Bonzo), the recently described marker for replicative senescence KLRG1 and the effector/memory marker CD45RO revealed that the populations of T cells present in the SF from arthritis patients with anergic and normally proliferating T lymphocytes are similar in seize and composition."],"dc:format.medium":["application/pdf"],"dc:subject":["Anergie"],"dc:title":["Hyporesponsive synovial fluid T cells in rheumatoid Arthritis","Anerge Synovialflüssigkeits-T-Zellen in Rheumatoider Arthritis"],"dc:type":["DoctoralThesis"]},"updated_at":"2026-07-24T02:21:58Z"}