Electrochemical Studies of The Interaction Between DNA and a Compound Having Anticancer Properties.

<p>Electrochemical method has been used to study the interaction between DNA and the compound N-(3',6'-dihydroxy-3-oxospiro[isobenzofuran-1(3H),9'-[9H]xanthen]-5-yl)-N'-(2-imidazoyl)urea having anticancer properties. A DNA modified nanometer-sized gold electrode was prepared by surface modification of a bare gold electrode using cysteamine. These electrodes have been characterized using electrochemical techniques and were used to study the interaction between DNA and the compound. Our results showed an increase in the adsorption peak current and a negative shift of E_1/2 in the oxidation of ferrocyanide on cysteamine and DNA modified electrodes. For the interaction between the DNA and the compound having anticancer properties, a decrease in peak current of the oxidation of ferrocyanide was observed. The decrease in peak current is attributed to the shielding of the electroactive species by the compound intercalated to the DNA from reaching the electrode surface. Therefore, only few of the electroactive species are able to reach the electrode surface.</p>

Name thesis:degree_name

MS (Master of Science)

Level thesis:degree_level

Thesis - unrestricted

Discipline thesis:degree_discipline

Chemistry

Year dc:date.issued

2011

Author dc:creator

• Pouliwe, Antibe

• Modified gold electrode
• Self assembly monolayer
• Chemistry
• Physical Sciences and Mathematics

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/1352

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-2543