Inhibition of <em>Escherichia coli</em> ATP Synthase Using Bioflavonoids.

<p>ATP synthase is the fundamental means of the cellular energy production in all organisms. Malfunction of ATP synthase is associated with multiple disease conditions. This enzyme is not only implicated in disease conditions but also likely to contribute in new therapies for multiple diseases by being a molecular target for several inhibitors. Bioflavonoids are a class of plant secondary metabolites known to exhibit antioxidants, chemopreventive, and chemotherapeutic properties. Their actual mode of action is not clear; however, some bioflavonoid are known to block the action of enzymes and other substances that promote the growth of cancer cells by binding to the multiple molecular targets in the body including ATP synthase. The most common dietary polyphenol resveratrol was shown to induce apoptosis via mitochondrial pathways and has chemopreventive properties against prostate cancer. Here we report the general inhibitory effects of dietary bioflavonoids on ATP synthase enzyme and intact <em>E. coli cells</em>.</p>

Name thesis:degree_name

MS (Master of Science)

Level thesis:degree_level

Thesis - restricted

Discipline thesis:degree_discipline

Biology

Year dc:date.issued

2011

Author dc:creator

• Chinnam, Naga babu

• Bioflavonoids
• ATP synthase
• Escherichia coli
• Bacteriology
• Life Sciences
• Microbial Physiology
• Microbiology

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/1298

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-2489