The Osteogenic Effects of 12 Weeks of Oral Supplementation of Androstenedione in Middle-Aged Men.

<p>Recent evidence suggests that declining bone mineral density (BMD) in males is related to declining circulating estrogens. The majority of endogenous plasma estrogens in males result from peripheral aromatization of plasma androgens. Thus, it was hypothesized that dietary supplementation with an aromatizable androgen (androstenedione) may stimulate increases in BMD.</p><p>BMD (measured by dual energy x-ray absorptiometry) and biochemical markers of bone turnover (1, 25 OH2 Vitamin D, calcitonin, deoxypyrodinoline, and parathyroid hormone) were assessed before and after 12 weeks of dietary androstenedione supplementation (200 mg/d). Twenty-four volunteers were randomized into either an androstenedione supplementation or placebo groups. Study volunteers also performed high intensity resistance training (RT) during the treatment period.</p><p>Androstenedione supplementation significantly increased plasma estradiol-17&#946; levels by 82%. However, the increase in estradiol-17&#946; did not impact bone turnover. The RT regimen did stimulate significant, local increases in BMD. Spine BMD was significantly increased by 6% for both treatment groups.</p>

Name thesis:degree_name

MA (Master of Arts)

Level thesis:degree_level

Thesis - unrestricted

Discipline thesis:degree_discipline

Kinesiology and Sport Studies

Year dc:date.issued

2003

Author dc:creator

• Wills, Troy Matthew

• Androstenedione
• resistance-training
• bone mineral density
• Kinesiology
• Life Sciences

Statement dc:rights

• Copyright by the authors.

Repository record dc:identifier

https://dc.etsu.edu/etd/829

OAI identifier oai:identifier

oai:dc.etsu.edu:etd-1986