{"id":{"repo_id":"ethz","oai_identifier":"oai:www.research-collection.ethz.ch:20.500.11850/550202"},"canonical_url":"https://search.dev.ndltd.org/etd/ethz/oai:www.research-collection.ethz.ch:20.500.11850/550202","repository":{"repo_id":"ethz","name":"ETH Zürich","base_url":"https://www.research-collection.ethz.ch/oai/request"},"display":{"title":"Simulations and Control of Artificial Microswimmers in Blood","abstract":"Artificial microswimmers are micron-sized devices that can propel in viscous fluids. Their potential applications are numerous, including targeted drug delivery, imaging, microsurgery, micro-sensing, assisted fertilization and micro-manipulation. To achieve these tasks, artificial microswimmers must reach regions of interest in a non-intrusive way by navigating through the complex blood circulatory system. Despite recent advances, reliable remote control of microswimmers in-vivo remains challenging because of the strong blood flows, the presence of blood cells, biocompatibility, noisy feedback and limited propelling velocities. A promising design of microswimmers, called artificial bacterial flagella (ABFs), are helical micro-robots that are propelled via external rotating magnetic fields. The swimming properties of ABFs in blood remain largely unexplored and no numerical model has been proposed to simulate such configurations. In this thesis, we study the control mechanisms and swimming properties of ABFs in blood flows, requiring two main components, red blood cells (RBCs) and ABFs, interacting hydrodynamically through the blood plasma. First, the RBC model is calibrated through hierarchical Bayesian inference on single-cell experiments, revealing the oblate stress-free state shape of the membrane cytoskeleton. We show that the calibrated model is transferable to more complex situations. Second, in the simplified case of ABFs swimming in free space, we derive control mechanisms and optimal path planning strategies to stir independently multiple ABFs with uniform magnetic fields. The method relies on reinforcement learning and is robust to thermal noise and background flow perturbations. We then consider ABFs swimming through suspensions of RBCs, revealing that ABFs swim faster in blood than in pure solvent. Finally, we simulate swarms of ABFs in confined geometries, showing interesting collective behavior that can be tuned by changing the external magnetic field.","abstract_html":"Artificial microswimmers are micron-sized devices that can propel in viscous fluids. Their potential applications are numerous, including targeted drug delivery, imaging, microsurgery, micro-sensing, assisted fertilization and micro-manipulation. To achieve these tasks, artificial microswimmers must reach regions of interest in a non-intrusive way by navigating through the complex blood circulatory system. Despite recent advances, reliable remote control of microswimmers in-vivo remains challenging because of the strong blood flows, the presence of blood cells, biocompatibility, noisy feedback and limited propelling velocities. A promising design of microswimmers, called artificial bacterial flagella (ABFs), are helical micro-robots that are propelled via external rotating magnetic fields. The swimming properties of ABFs in blood remain largely unexplored and no numerical model has been proposed to simulate such configurations. In this thesis, we study the control mechanisms and swimming properties of ABFs in blood flows, requiring two main components, red blood cells (RBCs) and ABFs, interacting hydrodynamically through the blood plasma. First, the RBC model is calibrated through hierarchical Bayesian inference on single-cell experiments, revealing the oblate stress-free state shape of the membrane cytoskeleton. We show that the calibrated model is transferable to more complex situations. Second, in the simplified case of ABFs swimming in free space, we derive control mechanisms and optimal path planning strategies to stir independently multiple ABFs with uniform magnetic fields. The method relies on reinforcement learning and is robust to thermal noise and background flow perturbations. We then consider ABFs swimming through suspensions of RBCs, revealing that ABFs swim faster in blood than in pure solvent. Finally, we simulate swarms of ABFs in confined geometries, showing interesting collective behavior that can be tuned by changing the external magnetic field.","abstract_has_math":false,"creators":["Amoudruz, Lucas"],"institution":"ETH Zurich","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":["Koumoutsakos, Petros","Schürle-Finke, Simone","Arampatzis, Georgios"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2022,"date_issued":"2022","date_published":"2022","updated_at":"2026-07-27T19:29:08Z","subjects":["info:eu-repo/classification/ddc/570","info:eu-repo/classification/ddc/004","Life sciences","Data processing, computer science"],"languages":["en"],"rights":["info:eu-repo/semantics/openAccess","Creative Commons Attribution 4.0 International"],"rights_urls":["http://creativecommons.org/licenses/by/4.0/"],"identifier_entries":[{"key":"dc:identifier","label":"Identifier","values":["https://doi.org/10.3929/ethz-b-000550202"],"render_values":[{"text":"https://doi.org/10.3929/ethz-b-000550202","href":"https://doi.org/10.3929/ethz-b-000550202","code":true}]}]},"links":{"outbound_url":"http://hdl.handle.net/20.500.11850/550202","outbound_label":"Handle","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Koumoutsakos, Petros","Schürle-Finke, Simone","Arampatzis, Georgios"]},{"key":"dc:creator","label":"Author","values":["Amoudruz, Lucas"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date","label":"Dc Date","values":["2022"]},{"key":"dc:publisher","label":"Institution","values":["ETH Zurich"]},{"key":"dc:type","label":"Dc Type","values":["info:eu-repo/semantics/doctoralThesis"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["info:eu-repo/classification/ddc/570","info:eu-repo/classification/ddc/004","Life sciences","Data processing, computer science"]}]},{"id":"language_rights","label":"Language and Rights","entries":[{"key":"dc:language","label":"Dc Language","values":["en"]},{"key":"dc:rights","label":"Dc Rights","values":["info:eu-repo/semantics/openAccess","http://creativecommons.org/licenses/by/4.0/","Creative Commons Attribution 4.0 International"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["http://hdl.handle.net/20.500.11850/550202","https://doi.org/10.3929/ethz-b-000550202"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description","label":"Description","values":["Artificial microswimmers are micron-sized devices that can propel in viscous fluids. Their potential applications are numerous, including targeted drug delivery, imaging, microsurgery, micro-sensing, assisted fertilization and micro-manipulation. To achieve these tasks, artificial microswimmers must reach regions of interest in a non-intrusive way by navigating through the complex blood circulatory system. Despite recent advances, reliable remote control of microswimmers in-vivo remains challenging because of the strong blood flows, the presence of blood cells, biocompatibility, noisy feedback and limited propelling velocities. A promising design of microswimmers, called artificial bacterial flagella (ABFs), are helical micro-robots that are propelled via external rotating magnetic fields. The swimming properties of ABFs in blood remain largely unexplored and no numerical model has been proposed to simulate such configurations. In this thesis, we study the control mechanisms and swimming properties of ABFs in blood flows, requiring two main components, red blood cells (RBCs) and ABFs, interacting hydrodynamically through the blood plasma. First, the RBC model is calibrated through hierarchical Bayesian inference on single-cell experiments, revealing the oblate stress-free state shape of the membrane cytoskeleton. We show that the calibrated model is transferable to more complex situations. Second, in the simplified case of ABFs swimming in free space, we derive control mechanisms and optimal path planning strategies to stir independently multiple ABFs with uniform magnetic fields. The method relies on reinforcement learning and is robust to thermal noise and background flow perturbations. We then consider ABFs swimming through suspensions of RBCs, revealing that ABFs swim faster in blood than in pure solvent. Finally, we simulate swarms of ABFs in confined geometries, showing interesting collective behavior that can be tuned by changing the external magnetic field."]},{"key":"dc:format","label":"Dc Format","values":["application/application/pdf"]},{"key":"dc:title","label":"Title","values":["Simulations and Control of Artificial Microswimmers in Blood"]}]}],"canonical_facts":{"dc:contributor":["Koumoutsakos, Petros","Schürle-Finke, Simone","Arampatzis, Georgios"],"dc:creator":["Amoudruz, Lucas"],"dc:date":["2022"],"dc:description":["Artificial microswimmers are micron-sized devices that can propel in viscous fluids. Their potential applications are numerous, including targeted drug delivery, imaging, microsurgery, micro-sensing, assisted fertilization and micro-manipulation. To achieve these tasks, artificial microswimmers must reach regions of interest in a non-intrusive way by navigating through the complex blood circulatory system. Despite recent advances, reliable remote control of microswimmers in-vivo remains challenging because of the strong blood flows, the presence of blood cells, biocompatibility, noisy feedback and limited propelling velocities. A promising design of microswimmers, called artificial bacterial flagella (ABFs), are helical micro-robots that are propelled via external rotating magnetic fields. The swimming properties of ABFs in blood remain largely unexplored and no numerical model has been proposed to simulate such configurations. In this thesis, we study the control mechanisms and swimming properties of ABFs in blood flows, requiring two main components, red blood cells (RBCs) and ABFs, interacting hydrodynamically through the blood plasma. First, the RBC model is calibrated through hierarchical Bayesian inference on single-cell experiments, revealing the oblate stress-free state shape of the membrane cytoskeleton. We show that the calibrated model is transferable to more complex situations. Second, in the simplified case of ABFs swimming in free space, we derive control mechanisms and optimal path planning strategies to stir independently multiple ABFs with uniform magnetic fields. The method relies on reinforcement learning and is robust to thermal noise and background flow perturbations. We then consider ABFs swimming through suspensions of RBCs, revealing that ABFs swim faster in blood than in pure solvent. Finally, we simulate swarms of ABFs in confined geometries, showing interesting collective behavior that can be tuned by changing the external magnetic field."],"dc:format":["application/application/pdf"],"dc:identifier":["http://hdl.handle.net/20.500.11850/550202","https://doi.org/10.3929/ethz-b-000550202"],"dc:language":["en"],"dc:publisher":["ETH Zurich"],"dc:rights":["info:eu-repo/semantics/openAccess","http://creativecommons.org/licenses/by/4.0/","Creative Commons Attribution 4.0 International"],"dc:subject":["info:eu-repo/classification/ddc/570","info:eu-repo/classification/ddc/004","Life sciences","Data processing, computer science"],"dc:title":["Simulations and Control of Artificial Microswimmers in Blood"],"dc:type":["info:eu-repo/semantics/doctoralThesis"]},"updated_at":"2026-07-27T19:29:08Z"}