The impact of HPV vaccination on HPV and cervical cancer in the Netherlands

Human papillomavirus (HPV) is a highly prevalent sexually transmitted virus, of which 150 types have been completely sequenced. Currently, about 14 HPV-types are considered ‘high risk’ for their potential to cause cervical cancer, the fourth most common cancer among women worldwide. In particular HPV-16 and HPV-18 are predominantly present in precancerous lesions and invasive cervical cancer. Luckily, vaccines have been developed to protect against these HPV-types. This thesis includes modeling studies in which we explore the role of naturally acquired immunity after clearing an HPV-16 and HPV-18 infection in the spread of HPV, as well as the impact of HPV vaccination on HPV and cervical cancer in the Netherlands.

Grantor dc:publisher

Erasmus University Rotterdam

Year dc:date.issued

2017

Author

• Matthijsse Suzette

• Human papillomavirus
• HPV
• cervical cancer
• vaccination
• screening
• mathematical modeling
• microsimulation

Handle dc:identifier.uri

http://hdl.handle.net/1765/98975

OAI identifier oai:identifier

oai:repub.eur.nl:98975