The purpose of this study was to determine whether acute maximal sprint exercise would elicit an inflammatory response in trained and untrained runners marked by increased systemic immune proteins and byproducts of oxidation, as well as to determine a time course for the presence of these markers. In procedures approved by the Eastern Michigan University College of Health and Human Services Human Subjects Review Board, subjects participated in a total of five study visits consisting of both exercise and blood draws. Blood analysis seems to indicate that there was a secondary tissue injury, which was responsible for the greatest changes in the measured parameters, although a larger population must be examined to confirm these results. It was also noted that increased cytokine concentrations preceded an increase in oxidative byproducts, indicating the existence of a cytokine dependant cascade, in addition to that created by the initial mechanical insult.
","abstract_html":"<p>The purpose of this study was to determine whether acute maximal sprint exercise would elicit an inflammatory response in trained and untrained runners marked by increased systemic immune proteins and byproducts of oxidation, as well as to determine a time course for the presence of these markers. In procedures approved by the Eastern Michigan University College of Health and Human Services Human Subjects Review Board, subjects participated in a total of five study visits consisting of both exercise and blood draws. Blood analysis seems to indicate that there was a secondary tissue injury, which was responsible for the greatest changes in the measured parameters, although a larger population must be examined to confirm these results. It was also noted that increased cytokine concentrations preceded an increase in oxidative byproducts, indicating the existence of a cytokine dependant cascade, in addition to that created by the initial mechanical insult.</p>","abstract_has_math":false,"creators":["Muth, Timothy A."],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Open Access Thesis","degree_discipline":"Health Promotion and Human Performance","degree_department":null,"school":null,"contributors":["Stephen J. McGregor, Ph.D., Chair","Lynne M. Shetron-Rama, Ph.D","Christopher Herman, Ph.D."],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2010,"date_issued":"2010-01-01T08:00:00Z","date_published":"2010-01-01T08:00:00Z","updated_at":"2026-07-24T02:16:36Z","subjects":["Exercise; inflammation","Exercise Science"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://commons.emich.edu/theses/299","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Stephen J. McGregor, Ph.D., Chair","Lynne M. Shetron-Rama, Ph.D","Christopher Herman, Ph.D."]},{"key":"dc:creator","label":"Author","values":["Muth, Timothy A."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.available","label":"Dc Date Available","values":["2011-04-08T07:00:00Z"]},{"key":"thesis:degree_discipline","label":"Discipline","values":["Health Promotion and Human Performance"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Open Access Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Exercise; inflammation","Exercise Science"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://commons.emich.edu/theses/299"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["The purpose of this study was to determine whether acute maximal sprint exercise would elicit an inflammatory response in trained and untrained runners marked by increased systemic immune proteins and byproducts of oxidation, as well as to determine a time course for the presence of these markers. In procedures approved by the Eastern Michigan University College of Health and Human Services Human Subjects Review Board, subjects participated in a total of five study visits consisting of both exercise and blood draws. Blood analysis seems to indicate that there was a secondary tissue injury, which was responsible for the greatest changes in the measured parameters, although a larger population must be examined to confirm these results. It was also noted that increased cytokine concentrations preceded an increase in oxidative byproducts, indicating the existence of a cytokine dependant cascade, in addition to that created by the initial mechanical insult.
"]},{"key":"dc:title","label":"Title","values":["The inflammatory response to acute maximal sprint exercise"]}]}],"canonical_facts":{"dc:contributor":["Stephen J. McGregor, Ph.D., Chair","Lynne M. Shetron-Rama, Ph.D","Christopher Herman, Ph.D."],"dc:creator":["Muth, Timothy A."],"dc:date.available":["2011-04-08T07:00:00Z"],"dc:description.abstract":["The purpose of this study was to determine whether acute maximal sprint exercise would elicit an inflammatory response in trained and untrained runners marked by increased systemic immune proteins and byproducts of oxidation, as well as to determine a time course for the presence of these markers. In procedures approved by the Eastern Michigan University College of Health and Human Services Human Subjects Review Board, subjects participated in a total of five study visits consisting of both exercise and blood draws. Blood analysis seems to indicate that there was a secondary tissue injury, which was responsible for the greatest changes in the measured parameters, although a larger population must be examined to confirm these results. It was also noted that increased cytokine concentrations preceded an increase in oxidative byproducts, indicating the existence of a cytokine dependant cascade, in addition to that created by the initial mechanical insult.
"],"dc:identifier":["https://commons.emich.edu/theses/299"],"dc:subject":["Exercise; inflammation","Exercise Science"],"dc:title":["The inflammatory response to acute maximal sprint exercise"],"thesis:degree_discipline":["Health Promotion and Human Performance"],"thesis:degree_level":["Open Access Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T02:16:36Z"}