An improved synthesis of the HDAC inhibitor trichostatin A

<p>Histone deacetylase inhibitors (HDIs) have found a wide variety of medicinal uses and are most noted for their specific apoptotic action towards cancer cells. Several hydroxamate HDIs have since been moved on to phase 1 and 2 clinical drug trials, with one having already been approved for treatment of advanced cutaneous T-cell lymphoma. Trichostatin A is one of the most potent known naturally-occurring inhibitors of histone deacetylase. Unfortunately for researchers, the syntheses that have been reported are both long and difficult, which leads to a low overall yield and therefore to a prohibitively expensive product, limiting its medicinal potential. This work builds on several previously published syntheses and shows a more efficient synthesis of Trichostatin A, which will make it more available for use in a variety of treatments.</p>

Name thesis:degree_name

Master of Science (MS)

Level thesis:degree_level

Open Access Thesis

Discipline thesis:degree_discipline

Chemistry

Year

2009

Author dc:creator

• Colombo, Joseph

Contributors dc:contributor

• Andrei Kornilov, PhD
• Harriet Lindsay, PhD
• Cory Emal, PhD

• Enzyme inhibitors
• Pharmaceutical chemistry
• Chemistry

Repository record dc:identifier

https://commons.emich.edu/theses/237

OAI identifier oai:identifier

oai:commons.emich.edu:theses-1236