Our objective was to test the hypothesis that increased GGT predicts an increased risk of type 2 diabetes (T2D) in elderly Mexican Americans.
Data from a population-based cohort study of 1789 community-dwelling Mexican American men and women, aged 60-101, in the SALSA study were used. Data for 1,203 participants without diabetes at baseline were evaluated for incident diabetes. Proportional hazard models were used to predict the probability of incident T2D by GGT level.
After adjustment for age, gender, smoking, alcohol use, and BMI, the risk of developing T2D associated with GGT was significant at 1.4 (95% CI 1.2 -1.7). However, when the model was adjusted for fasting serum glucose, the risk was attenuated by 20%, and the confidence interval included 1.0 (HR 1.1, 95% CI 0.8-1.5).
In conclusion, elevated levels of GGT may be associated with an increased risk of T2D, but additional studies need to be done in this population.
","abstract_html":"<p>Our objective was to test the hypothesis that increased GGT predicts an increased risk of type 2 diabetes (T2D) in elderly Mexican Americans.</p> <p>Data from a population-based cohort study of 1789 community-dwelling Mexican American men and women, aged 60-101, in the SALSA study were used. Data for 1,203 participants without diabetes at baseline were evaluated for incident diabetes. Proportional hazard models were used to predict the probability of incident T2D by GGT level.</p> <p>After adjustment for age, gender, smoking, alcohol use, and BMI, the risk of developing T2D associated with GGT was significant at 1.4 (95% CI 1.2 -1.7). However, when the model was adjusted for fasting serum glucose, the risk was attenuated by 20%, and the confidence interval included 1.0 (HR 1.1, 95% CI 0.8-1.5).</p> <p>In conclusion, elevated levels of GGT may be associated with an increased risk of T2D, but additional studies need to be done in this population.</p>","abstract_has_math":false,"creators":["Blythe, Lynn"],"institution":null,"degree_name":"Master of Science (MS)","degree_level":"Open Access Thesis","degree_discipline":"Health Sciences","degree_department":null,"school":null,"contributors":["Stephen Sonstein, PhD, Chair","Mary N. Haan, MPH, DrPH"],"advisors":[],"committee_chairs":[],"committee_members":[],"year":2007,"date_issued":"2007-01-01T08:00:00Z","date_published":"2007-01-01T08:00:00Z","updated_at":"2026-07-24T02:16:24Z","subjects":["Diabetes Research","Health and Medical Administration"],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"https://commons.emich.edu/theses/46","outbound_label":"Repository record","outbound_source":"dc:identifier"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:contributor","label":"Contributor","values":["Stephen Sonstein, PhD, Chair","Mary N. Haan, MPH, DrPH"]},{"key":"dc:creator","label":"Author","values":["Blythe, Lynn"]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"thesis:degree_discipline","label":"Discipline","values":["Health Sciences"]},{"key":"thesis:degree_level","label":"Degree Level","values":["Open Access Thesis"]},{"key":"thesis:degree_name","label":"Degree Name","values":["Master of Science (MS)"]}]},{"id":"subjects_keywords","label":"Subjects and Keywords","entries":[{"key":"dc:subject","label":"Dc Subject","values":["Diabetes Research","Health and Medical Administration"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier","label":"Identifier","values":["https://commons.emich.edu/theses/46"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["Our objective was to test the hypothesis that increased GGT predicts an increased risk of type 2 diabetes (T2D) in elderly Mexican Americans.
Data from a population-based cohort study of 1789 community-dwelling Mexican American men and women, aged 60-101, in the SALSA study were used. Data for 1,203 participants without diabetes at baseline were evaluated for incident diabetes. Proportional hazard models were used to predict the probability of incident T2D by GGT level.
After adjustment for age, gender, smoking, alcohol use, and BMI, the risk of developing T2D associated with GGT was significant at 1.4 (95% CI 1.2 -1.7). However, when the model was adjusted for fasting serum glucose, the risk was attenuated by 20%, and the confidence interval included 1.0 (HR 1.1, 95% CI 0.8-1.5).
In conclusion, elevated levels of GGT may be associated with an increased risk of T2D, but additional studies need to be done in this population.
"]},{"key":"dc:title","label":"Title","values":["Serum gamma-glutamyltransferase and the risk of type 2 diabetes in a population-based cohort study of older Mexican Americans"]}]}],"canonical_facts":{"dc:contributor":["Stephen Sonstein, PhD, Chair","Mary N. Haan, MPH, DrPH"],"dc:creator":["Blythe, Lynn"],"dc:description.abstract":["Our objective was to test the hypothesis that increased GGT predicts an increased risk of type 2 diabetes (T2D) in elderly Mexican Americans.
Data from a population-based cohort study of 1789 community-dwelling Mexican American men and women, aged 60-101, in the SALSA study were used. Data for 1,203 participants without diabetes at baseline were evaluated for incident diabetes. Proportional hazard models were used to predict the probability of incident T2D by GGT level.
After adjustment for age, gender, smoking, alcohol use, and BMI, the risk of developing T2D associated with GGT was significant at 1.4 (95% CI 1.2 -1.7). However, when the model was adjusted for fasting serum glucose, the risk was attenuated by 20%, and the confidence interval included 1.0 (HR 1.1, 95% CI 0.8-1.5).
In conclusion, elevated levels of GGT may be associated with an increased risk of T2D, but additional studies need to be done in this population.
"],"dc:identifier":["https://commons.emich.edu/theses/46"],"dc:subject":["Diabetes Research","Health and Medical Administration"],"dc:title":["Serum gamma-glutamyltransferase and the risk of type 2 diabetes in a population-based cohort study of older Mexican Americans"],"thesis:degree_discipline":["Health Sciences"],"thesis:degree_level":["Open Access Thesis"],"thesis:degree_name":["Master of Science (MS)"]},"updated_at":"2026-07-24T02:16:24Z"}