Improving outcomes for women with endometriosis
type: CreativeWork
description: Background “Endometriosis is a chronic hormone-dependent inflammatory disorder that affects 6- 10% of women of reproductive age. It is defined by the presence of endometrial-like tissue (lesions) found outside the uterine cavity, usually within the pelvis. The most widely reported symptoms of endometriosis are chronic pelvic pain and infertility. Endometriosis-associated pain can have a significant and debilitating impact on quality of life. In the United Kingdom, the impact on society of endometriosis is estimated at £8.2 billion in healthcare/treatment costs coupled with lost productivity. The exact aetiology of endometriosis is unknown. Standard treatments such as analgesic regimens, drugs that induce hormone suppression or invasive surgery can be associated with unacceptable side effects or complications. Notably many medical treatments are contraceptive, and endometriosis-associated symptoms typically recur after women stop taking drug treatments or after surgery. New therapies are therefore needed that: (i) can reduce painful symptoms associated with the condition (ii) are disease modifying (reduce lesion size) (iii) preserve the patients’ ability to conceive whilst on medication (iv) have no, or limited, side effects and (v) are acceptable to women with endometriosis.” Objectives “The two aims of my thesis were (a) to identify research priorities for endometriosis and (b) to determine the feasibility of a future multi-centre, large randomised controlled trial (RCT) to evaluate the effectiveness of Omega-3 purified fatty acids (PUFA) for endometriosis-associated pain. To achieve these objectives, I have (a) engaged with experts in the management of endometriosis, women with endometriosis and prepared a report of the research uncertainties, using a template provided by the James Lind Alliance (JLA) and (b) undertaken a two-arm, double-blind pilot randomised controlled clinical trial.” (a) Identifying research priorities for endometriosis “The JLA brings patient…
abstract: Background “Endometriosis is a chronic hormone-dependent inflammatory disorder that affects 6- 10% of women of reproductive age. It is defined by the presence of endometrial-like tissue (lesions) found outside the uterine cavity, usually within the pelvis. The most widely reported symptoms of endometriosis are chronic pelvic pain and infertility. Endometriosis-associated pain can have a significant and debilitating impact on quality of life. In the United Kingdom, the impact on society of endometriosis is estimated at £8.2 billion in healthcare/treatment costs coupled with lost productivity. The exact aetiology of endometriosis is unknown. Standard treatments such as analgesic regimens, drugs that induce hormone suppression or invasive surgery can be associated with unacceptable side effects or complications. Notably many medical treatments are contraceptive, and endometriosis-associated symptoms typically recur after women stop taking drug treatments or after surgery. New therapies are therefore needed that: (i) can reduce painful symptoms associated with the condition (ii) are disease modifying (reduce lesion size) (iii) preserve the patients’ ability to conceive whilst on medication (iv) have no, or limited, side effects and (v) are acceptable to women with endometriosis.” Objectives “The two aims of my thesis were (a) to identify research priorities for endometriosis and (b) to determine the feasibility of a future multi-centre, large randomised controlled trial (RCT) to evaluate the effectiveness of Omega-3 purified fatty acids (PUFA) for endometriosis-associated pain. To achieve these objectives, I have (a) engaged with experts in the management of endometriosis, women with endometriosis and prepared a report of the research uncertainties, using a template provided by the James Lind Alliance (JLA) and (b) undertaken a two-arm, double-blind pilot randomised controlled clinical trial.” (a) Identifying research priorities for endometriosis “The JLA brings patient…
author: Abokhrais, Ibtisam Mohamad S.
language: en
keywords: endometriosis, Omega-3 fatty acids, endometriosis-associated pain, potential treatment, double-blind
date published: 2019-07-06
date modified: 2026-07-24T02:13:55Z
provider: University of Edinburgh
publisher: Networked Digital Library of Theses and Dissertations
type: WebPage
source organization: The University of Edinburgh

PropertyValue
property ID: Handle
value: http://hdl.handle.net/1842/35806