Significance of variation in concentration of chlorides, acid, and pepsin, in the gastric contents, with particular reference to the control of gastric acidity

The concentration -variations of chlorides, acid and pepsin, in gastric contents, have been studied. One hundred investigations of chlorides and acid alone, and fifteen of pepsin were carried out in both normal and pathological cases. Estimations of these constituents were also performed on the secretion obtained from an isolated pouch, with nervous connections intact, constructed in the lower half of the fundus of a dog's stomach. I. The chief diagnostic value of estimations of the chlorides, in addition to that of the acid, lies in assisting differentation of such pathological conditions of the stomach as are characterised by complete absence of 'free' hydrochloric acid, II. The determination of pepsin -variations seems . to be of most service in distinguishing between Carcinoma of the Stomach and Gastric or Duodenal Ulcer. III. The mechanism of control of gastric acidity is dependent upon several contributory factors. The suggestion is made that the gland -cells of the pyloric segment of the stomach represent the principal source of secreted neutral chiorids.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

1929

Author dc:creator

• Mitchell, Thomas Carlyle

Handle dc:identifier.uri

http://hdl.handle.net/1842/35365

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/35365