Involvement of the WT1 and p16 genes in Wilms' tumour and human malignant mesothelioma

Normal cellular homeostasis is established and maintained by the positive and negative regulatory activities of many genes. When these genes are mutated to forms that can contribute to tumorigenesis, either by dominant, gain of function mutations in positive regulators or recessive, loss of function mutations in negative regulators, they are termed oncogenes or tumour suppressor genes, respectively. Identified human tumour suppressor genes, though still relatively few in number, are found to be active in many different cellular processes. I have studied two such genes, the WT1 and p16 genes, which in their wild type forms are known to contribute to development of the urogenital system and the mesothelium (WTI) and to control of the cell cycle (pi6).

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

1996

Author dc:creator

• Williamson, Kathleen Anne

Handle dc:identifier.uri

http://hdl.handle.net/1842/34461

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/34461