Cytogenetic and molecular analysis of follicular non-Hodkin's lymphoma

The incidence of the reciprocal translocation t (14;18)(q32;q21) in follicular lymphoma varies from 50% to 90% in American series. In the largest series from Europe, the translocation was present in only 21/51 (41%) of cases. The wide variety in incidence may in part be due to the method of detection used - usually cytogenetics alone or a combination of Southern blotting and polymerase chain amplification (PCR) of DNA extracted from malignant tissue. The shortcomings of each technique suggest that a combination of all three may best determine the true incidence of the translocation.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

1992

Author dc:creator

• Turner, Gillian E.

Handle dc:identifier.uri

http://hdl.handle.net/1842/34265

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/34265