{"id":{"repo_id":"edinburgh","oai_identifier":"oai:era.ed.ac.uk:1842/30897"},"canonical_url":"https://search.dev.ndltd.org/etd/edinburgh/oai:era.ed.ac.uk:1842/30897","repository":{"repo_id":"edinburgh","name":"University of Edinburgh","base_url":"https://era.ed.ac.uk/server/oai/request"},"display":{"title":"Bone marrow transplantation in infancy and childhood","abstract":"During a bone marrow transplant there is a major risk of infection either due to the specific disease or as a result of the required preconditioning. Severely neutropenic patients benefit from receiving prophylactic antimicrobial agents within a protected environment and the thesis opens with a discussion of and a comparison between the different ways of achieving this protection and an assessment of the contribution of each component.","abstract_html":"During a bone marrow transplant there is a major risk of infection either due to the specific disease or as a result of the required preconditioning. Severely neutropenic patients benefit from receiving prophylactic antimicrobial agents within a protected environment and the thesis opens with a discussion of and a comparison between the different ways of achieving this protection and an assessment of the contribution of each component.","abstract_has_math":false,"creators":["Watson, James Graham."],"institution":"The University of Edinburgh","degree_name":null,"degree_level":null,"degree_discipline":null,"degree_department":null,"school":null,"contributors":[],"advisors":[],"committee_chairs":[],"committee_members":[],"year":1981,"date_issued":"1981","date_published":"1981","updated_at":"2026-07-24T02:14:05Z","subjects":[],"languages":[],"rights":[],"rights_urls":[],"identifier_entries":[]},"links":{"outbound_url":"http://hdl.handle.net/1842/30897","outbound_label":"Handle","outbound_source":"dc:identifier.uri"},"metadata_groups":[{"id":"people","label":"People","entries":[{"key":"dc:creator","label":"Author","values":["Watson, James Graham."]}]},{"id":"academic_context","label":"Academic Context","entries":[{"key":"dc:date.accessioned","label":"Dc Date Accessioned","values":["2018-05-22T12:49:41Z"]},{"key":"dc:date.available","label":"Dc Date Available","values":["2018-05-22T12:49:41Z"]},{"key":"dc:date.issued","label":"Date","values":["1981"]},{"key":"dc:publisher","label":"Institution","values":["The University of Edinburgh"]},{"key":"dc:relation.isreferencedby","label":"Dc Relation Isreferencedby","values":["Already catalogued"]},{"key":"dc:type","label":"Dc Type","values":["Thesis or Dissertation"]},{"key":"dc:type.qualificationlevel","label":"Dc Type Qualificationlevel","values":["Doctoral"]},{"key":"dc:type.qualificationname","label":"Dc Type Qualificationname","values":["MD Doctor of Medicine"]}]},{"id":"identifiers","label":"Identifiers","entries":[{"key":"dc:identifier.uri","label":"Identifier URI","values":["http://hdl.handle.net/1842/30897"]}]},{"id":"additional","label":"Additional Metadata","entries":[{"key":"dc:description.abstract","label":"Abstract","values":["During a bone marrow transplant there is a major risk of infection either due to the specific disease or as a result of the required preconditioning. Severely neutropenic patients benefit from receiving prophylactic antimicrobial agents within a protected environment and the thesis opens with a discussion of and a comparison between the different ways of achieving this protection and an assessment of the contribution of each component.","n the second part there is description and discussion of the practical aspects of establishing and managing isolator tents for infants and children undergoing bone marrow transplantation in the middle of an open ward in a Children's Hospital built 70 years ago. The isolators were found to be effective, practical and highly acceptable to almost all children, their relatives and the attending staff. A pathogen—free food service complementary to the degree of isolation was established and is described. Three different regimens of prophylactic antimicrobial agents were evaluated in the patients undergoing marrow transplantation and the newer regimen using co—trimoxazole found to be superior in preventing infection but to have several disadvantages. Extensive surface and orifice decontamination measures were not found to be worthwhile.","The third section discusses the practical aspects of caring for infants and children undergoing bone marrow transplantation. The management and progress of 10 infants with severe combined immune deficiency, and 10 children with severe aplastic anaemia is described in detail with particular emphasis on the immune reconstitution of the survivors. The outcome of eleven children with acute myeloid leukaemia who underwent allogeneic transplantation is described and compared with that of children who did not receive a marrow graft. Measures used to attempt germfree deliveries without caesarian section are described, evaluated and found wanting.","Viral infections after grafting remain a problem and experience with cytomegalovirus and papovavirus is discussed. Infections with herpes simplex and varicella-zoster virus after grafting are discussed with particular reference to 19 marrow transplant recipients treated with acycloguanosine which was probably effective though only in the short term.","The thesis concludes with a discussion of the requirement for marrow grafting facilities in the United Kingdom and finds that six separate centres, each with five designated beds will be the minimum required For matched sibling alloqrafts given the present indications and this service will cost not less than £1.6 million per annum."]},{"key":"dc:title","label":"Title","values":["Bone marrow transplantation in infancy and childhood"]}]}],"canonical_facts":{"dc:creator":["Watson, James Graham."],"dc:date.accessioned":["2018-05-22T12:49:41Z"],"dc:date.available":["2018-05-22T12:49:41Z"],"dc:date.issued":["1981"],"dc:description.abstract":["During a bone marrow transplant there is a major risk of infection either due to the specific disease or as a result of the required preconditioning. Severely neutropenic patients benefit from receiving prophylactic antimicrobial agents within a protected environment and the thesis opens with a discussion of and a comparison between the different ways of achieving this protection and an assessment of the contribution of each component.","n the second part there is description and discussion of the practical aspects of establishing and managing isolator tents for infants and children undergoing bone marrow transplantation in the middle of an open ward in a Children's Hospital built 70 years ago. The isolators were found to be effective, practical and highly acceptable to almost all children, their relatives and the attending staff. A pathogen—free food service complementary to the degree of isolation was established and is described. Three different regimens of prophylactic antimicrobial agents were evaluated in the patients undergoing marrow transplantation and the newer regimen using co—trimoxazole found to be superior in preventing infection but to have several disadvantages. Extensive surface and orifice decontamination measures were not found to be worthwhile.","The third section discusses the practical aspects of caring for infants and children undergoing bone marrow transplantation. The management and progress of 10 infants with severe combined immune deficiency, and 10 children with severe aplastic anaemia is described in detail with particular emphasis on the immune reconstitution of the survivors. The outcome of eleven children with acute myeloid leukaemia who underwent allogeneic transplantation is described and compared with that of children who did not receive a marrow graft. Measures used to attempt germfree deliveries without caesarian section are described, evaluated and found wanting.","Viral infections after grafting remain a problem and experience with cytomegalovirus and papovavirus is discussed. Infections with herpes simplex and varicella-zoster virus after grafting are discussed with particular reference to 19 marrow transplant recipients treated with acycloguanosine which was probably effective though only in the short term.","The thesis concludes with a discussion of the requirement for marrow grafting facilities in the United Kingdom and finds that six separate centres, each with five designated beds will be the minimum required For matched sibling alloqrafts given the present indications and this service will cost not less than £1.6 million per annum."],"dc:identifier.uri":["http://hdl.handle.net/1842/30897"],"dc:publisher":["The University of Edinburgh"],"dc:relation.isreferencedby":["Already catalogued"],"dc:title":["Bone marrow transplantation in infancy and childhood"],"dc:type":["Thesis or Dissertation"],"dc:type.qualificationlevel":["Doctoral"],"dc:type.qualificationname":["MD Doctor of Medicine"]},"updated_at":"2026-07-24T02:14:05Z"}