Glucocorticoids and angiogenesis

Angiogenesis is the creation of new blood vessels from the existing vasculature that occurs through a complex series of interactions and is tightly regulated. Glucocorticoids are acknowledged to inhibit angiogenesis at high concentrations but whether endogenous glucocorticoid concentrations are sufficient to regulate angiogenesis is unclear. Adrenal synthesis is not the sole determinant of glucocorticoid tissue concentration however and 11 ßhydroxysteroid dehydrogenase type 1 (11ßHSD1) that is present in the vessel wall may regenerate active glucocorticoids from 1 lketo-substrates and therefore amplify local tissue concentrations. Thus it was hypothesised that endogenous glucocorticoids regulated by 11ßHSD1 inhibit angiogenesis.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

2005

Author dc:creator

• Small, Gary Robert

Handle dc:identifier.uri

http://hdl.handle.net/1842/29367

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/29367