Vascular biology in the menstrual cycle, pregnancy and pre-eclampsia

BACKGROUND Thrombotic disease is rare but significant in women of reproductive age. Thrombosis and thromboembolism are the most common causes of maternal death in the United Kingdom. Pre-eclampsia is associated with increase in immediate and lifetime risk of adverse thrombotic events. Both pregnancy and the follicular phase are associated with arterial thrombosis and myocardial infarction. Modulation of haemostatic mechanisms in reproductive physiology and disease is not well understood. Outwith pregnancy, stimulated tissue plasminogen activator (t-PA) release, platelet activation, arterial stiffness and circulating endothelial progenitor cell (EPC) number are established indicators of vascular pathology and prognosis.

Grantor dc:publisher

The University of Edinburgh

Year dc:date.issued

2010

Author dc:creator

• Robb, Amy Olivia

Handle dc:identifier.uri

http://hdl.handle.net/1842/29337

OAI identifier oai:identifier

oai:era.ed.ac.uk:1842/29337